Spots Global Cancer Trial Database for AMAZE-lung: Amivantamab, Lazertinib and Bevacizumab in Patients With EGFR-mutant Advanced Non-small Cell Lung Cancer With Progression on Previous Third-generation EGFR-TKI
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Trial Identification
Brief Title: AMAZE-lung: Amivantamab, Lazertinib and Bevacizumab in Patients With EGFR-mutant Advanced Non-small Cell Lung Cancer With Progression on Previous Third-generation EGFR-TKI
Official Title: A Multicentre Single-arm Phase II Trial of Amivantamab, Lazertinib Plus Bevacizumab in Patients With EGFR-mutant Advanced NSCLC With Progression on Previous Third-generation EGFR-TKI
Study ID: NCT05601973
Conditions
Study Description
Brief Summary: AMAZE-lung is a multicenter single-arm phase II trial. The protocol treatment consists of amivantamab, lazertinib and bevacizumab (Zirabev®), given in a three-weekly regimen. The primary objective of the trial is to assess the efficacy of amivantamab and bevacizumab added to continued treatment with the third-generation EGFR-TKI lazertinib, in patients with EGFR-mutant advanced NSCLC, who have been previously treated with a third-generation EGFR-TKI in order to provide data on treatment effect and sample size required for a future phase III trial. In addition, the safety of the treatment combination will be evaluated.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Chu Angers, Angers, , France
Centre Hospitalier d'Avignon, Avignon, , France
Centre Léon Bérard, Lyon, , France
SS Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, , Italy
AO SM Misericorida Perugia, Perugia, , Italy
Netherlands Cancer Institute (NKI), Amsterdam, , Netherlands
National University Hospital, Singapore, , Singapore
Hospital Universitario de A Coruña, A Coruña, , Spain
Hospital Universitario Alicante Dr Balmis ISABIAL, Alicante, , Spain
ICO Badalona, Badalona, , Spain
Vall d´Hebron University Hospital VHIO, Barcelona, , Spain
Hospital Universitario Basurto, Bilbao, , Spain
Catalan Institute of Oncology, L'Hospitalet De Llobregat, , Spain
Hospital Universitario Fundación Jiménez Díaz, Madrid, , Spain
Hospital clínico universitario de Valladolid, Valladolid, , Spain
Istituto Oncologico della Svizzera Italiana, Bellinzona, , Switzerland
Universitätsklinik für Medizinische Onkologie, Inselspital, Bern, , Switzerland
HFR Fribourg, Fribourg, , Switzerland
Hôpitaux universitaires de Genève (HUG), Genève, , Switzerland
Kantonsspital St. Gallen, Saint Gallen, , Switzerland
The Royal Marsden NHS Foundation Trust, London, , United Kingdom
Contact Details
Name: Ross Soo, MD FRACP
Affiliation: National University Hospital, Singapore
Role: STUDY_CHAIR
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