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Spots Global Cancer Trial Database for A Study of Nivolumab + Chemotherapy or Nivolumab + Ipilimumab Versus Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Who Failed 1L or 2L EGFR Tyrosine Kinase Inhibitor (TKI) Therapy

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Trial Identification

Brief Title: A Study of Nivolumab + Chemotherapy or Nivolumab + Ipilimumab Versus Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Who Failed 1L or 2L EGFR Tyrosine Kinase Inhibitor (TKI) Therapy

Official Title: Open-Label, Randomized Trial of Nivolumab (BMS-936558) Plus Pemetrexed/Platinum or Nivolumab Plus Ipilimumab (BMS-734016) vs Pemetrexed Plus Platinum in Stage IV or Recurrent Non-Small Cell Lung Cancer (NSCLC) Subjects With Epidermal Growth Factor Receptor (EGFR) Mutation Who Failed 1L or 2L EGFR Tyrosine Kinase Inhibitor Therapy

Study ID: NCT02864251

Study Description

Brief Summary: The main purpose of this study is to determine whether nivolumab + chemotherapy is effective as compared to chemotherapy in the treatment of patients with EGFR mutation, NSCLC who failed first line (1L) or second-line (2L) EGFR TKI therapy.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Pacific Shores Medical Group, Long Beach, California, United States

Local Institution - 0029, Los Angeles, California, United States

Local Institution - 0033, Los Angeles, California, United States

Local Institution - 0061, Orange, California, United States

Torrance Memorial Physican Network, Redondo Beach, California, United States

Local Institution - 0003, New Haven, Connecticut, United States

Local Institution - 0004, Chicago, Illinois, United States

Johns Hopkins University, Baltimore, Maryland, United States

Local Institution - 0002, Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Dana Farber Cancer Institute, Boston, Massachusetts, United States

Local Institution - 0064, New York, New York, United States

Duke University Medical Center, Butner, North Carolina, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

Texas Health Physicians Group, Arlington, Texas, United States

Baylor Scott and White Research Institute, Temple, Texas, United States

Local Institution - 0063, Tyler, Texas, United States

Local Institution - 0001, Salt Lake City, Utah, United States

Local Institution - 0166, Edmonton, Alberta, Canada

Local Institution - 0168, Montreal, Quebec, Canada

Local Institution, Beijing, Beijing, China

Local Institution, Beijing, Beijing, China

Local Institution, Chongqing, Chongqing, China

Local Institution, Guangzhou, Guangdong, China

Local Institution, Zhengzhou, Henan, China

Local Institution, Hong Kong, Hong Kong, China

Local Institution - 0043, Changsha, Hunan, China

Local Institution, Changchun, Jilin, China

Local Institution, Changchun, Jilin, China

Local Institution, Xian, Shan3xi, China

Local Institution, Shanghai, Shanghai, China

Local Institution, Shanghai, Shanghai, China

Local Institution, Chengdu, Sichuan, China

Local Institution - 0016, Hangzhou, Zhejiang, China

Local Institution - 0017, Hangzhou, Zhejiang, China

Local Institution, Hangzhou, Zhejiang, China

Local Institution, Marseille, , France

Local Institution - 0156, Paris, , France

Local Institution, Rennes, , France

Local Institution, Toulouse cedex 9, , France

Local Institution - 0027, Hong Kong, , Hong Kong

Local Institution - 0024, Hong Kong, , Hong Kong

Local Institution, Shatin, , Hong Kong

Local Institution, Nagoya-shi, Aichi, Japan

Local Institution, Hirosaki-shi, Aomori, Japan

Local Institution, Matsuyama, Ehime, Japan

Local Institution, Iizuka, Fukuoka, Japan

Local Institution - 0059, Kurume, Fukuoka, Japan

Local Institution, Fukushima-shi, Fukushima, Japan

Local Institution, Koriyama, Fukushima, Japan

Local Institution, Fukuyama, Hiroshima, Japan

Local Institution, Hiroshima-Shi, Hiroshima, Japan

Local Institution - 0070, Sapporo, Hokkaido, Japan

Local Institution, Himeji-shi, Hyogo, Japan

Local Institution - 0097, Itami, Hyogo, Japan

Local Institution, Kobe City, Hyogo, Japan

Local Institution, Kobe, Hyogo, Japan

Local Institution, Bunkyo-ku, Kanagawa, Japan

Local Institution - 0081, Yokohama-shi, Kanagawa, Japan

Local Institution, Yokohama, Kanagawa, Japan

Local Institution, Yokohama, Kanagawa, Japan

Local Institution, Kumamoto-shi, Kumamoto, Japan

Local Institution, Natori-shi, Miyagi, Japan

Local Institution - 0077, Sendai-shi, Miyagi, Japan

Local Institution, Hirakata-shi, Osaka, Japan

Local Institution, Kishiwada shi, Osaka, Japan

Local Institution - 0058, Osakasayama, Osaka, Japan

Local Institution, Sakai, Osaka, Japan

Local Institution - 0076, Hidaka, Saitama, Japan

Local Institution, Kitaadachi-gun, Saitama, Japan

Local Institution - 0069, Chuo, Tokyo, Japan

Local Institution - 0078, Koto-ku, Tokyo, Japan

Local Institution, Ube Shi, Yamaguchi, Japan

Local Institution, Chiba, , Japan

Local Institution, Fukuoka, , Japan

Local Institution, Fukuoka, , Japan

Local Institution, Niigata, , Japan

Local Institution - 0079, Tokyo, , Japan

Local Institution, Toyama, , Japan

Local Institution, Wakayama, , Japan

Local Institution - 0038, Seoul, Seoul Teugbyeolsi, Korea, Republic of

Local Institution - 0037, Seoul, Seoul Teugbyeolsi, Korea, Republic of

Local Institution - 0035, Seoul, Seoul Teugbyeolsi, Korea, Republic of

Local Institution, Cheogju-si, , Korea, Republic of

Local Institution, Gyeonggi-do,, , Korea, Republic of

Local Institution - 0036, Gyeonggi-do, , Korea, Republic of

Local Institution, Inchoen, , Korea, Republic of

Local Institution, Seoul, , Korea, Republic of

Local Institution - 0042, Singapore, , Singapore

Local Institution - 0041, Singapore, , Singapore

Local Institution - 0158, Barcelona, , Spain

Local Institution, Hospitalet de Llobregat, , Spain

Local Institution, Madrid, , Spain

Local Institution, Majadahonda, , Spain

Local Institution, Malaga, , Spain

Local Institution, Zaragoza, , Spain

Local Institution - 0021, Tainan, TNN, Taiwan

Local Institution - 0045, Chiayi, , Taiwan

Local Institution, Kaohsiung City, , Taiwan

Local Institution, Kaohsiung city, , Taiwan

Local Institution - 0019, Kaohsiung, , Taiwan

Local Institution - 0018, Taichung, , Taiwan

Local Institution, Taichung, , Taiwan

Local Institution, Tainan, , Taiwan

Local Institution, Taipei City, , Taiwan

Local Institution, Taipei, , Taiwan

Local Institution - 0066, Taipei, , Taiwan

Local Institution - 0108, Taipei, , Taiwan

Local Institution - 0023, Taipei, , Taiwan

Local Institution, Taoyuan, , Taiwan

Contact Details

Name: Bristol-Myers Squibb

Affiliation: Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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