Spots Global Cancer Trial Database for A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC
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Trial Identification
Brief Title: A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC
Official Title: Phase I/II, Open-label, Dose Escalation and Dose Expansion Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC
Study ID: NCT04995523
Conditions
Interventions
Study Description
Brief Summary: This is a Phase I/II study designed to evaluate if experimental anti-TIGIT/anti-PD-1 bispecific antibody rilvegostomig (AZD2936) is safe, tolerable and efficacious in participants with Advanced or Metastatic Non-small Cell Lung Cancer.
Detailed Description: This is a first-time-in-human (FTIH), open-label, multicenter, multi-part, dose-escalation and dose-expansion study to evaluate the safety, pharmacokinetics (PK), pharmacodynamics, and efficacy of rilvegostomig (AZD2936) in adult participants with stage III unresectable or stage IV NSCLC. The study includes 4 parts: Part A (dose escalation) and Parts B-D (dose expansion).
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Chicago, Illinois, United States
Research Site, Rochester, Minnesota, United States
Research Site, Fairfax, Virginia, United States
Research Site, Melbourne, , Australia
Research Site, Anderlecht, , Belgium
Research Site, Leuven, , Belgium
Research Site, Florianópolis, , Brazil
Research Site, Natal, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Rio de Janeiro, , Brazil
Research Site, Sao Paulo, , Brazil
Research Site, Chengdu, , China
Research Site, Chongqing, , China
Research Site, Copenhagen, , Denmark
Research Site, Dijon, , France
Research Site, Toulouse Cedex 09, , France
Research Site, Kashiwa, , Japan
Research Site, Niigata-shi, , Japan
Research Site, Sendai-shi, , Japan
Research Site, Tokyo, , Japan
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Kuala Lumpur, , Malaysia
Research Site, Kuching, , Malaysia
Research Site, Groningen, , Netherlands
Research Site, Leiden, , Netherlands
Research Site, Utrecht, , Netherlands
Research Site, Barcelona, , Spain
Research Site, Madrid, , Spain
Research Site, Madrid, , Spain
Research Site, Taichung, , Taiwan
Research Site, Taichung, , Taiwan
Research Site, Tainan City, , Taiwan
Research Site, Taipei City, , Taiwan
Research Site, Bangkok, , Thailand
Research Site, Muang, , Thailand
Research Site, Mueang Chanthaburi, , Thailand
Contact Details
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