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Brief Title: A Study to Evaluate Bevacizumab and Chemotherapy or Tarceva in Treating Recurrent or Refractory NSCLC (Non-Small Cell Lung Cancer)
Official Title: A Phase II, Multicenter, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Bevacizumab in Combination With Chemotherapy (Docetaxel or Pemetrexed) or Tarceva (Erlotinib) Compared With Chemotherapy (Docetaxel or Pemetrexed) Alone for Treatment of Recurrent or Refractory Non-Small Cell Lung Cancer
Study ID: NCT00095225
Brief Summary: This Phase II, multicenter, randomized trial is designed to make preliminary evaluations of the efficacy of combining bevacizumab with chemotherapy (docetaxel or pemetrexed) or Tarceva relative to chemotherapy (docetaxel or pemetrexed) alone in patients with previously treated advanced NSCLC.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Comprehensive Blood and Cancer Center (TORI), Bakersfield, California, United States
Bay Area Cancer Research Group, Concord, California, United States
Virginia K. Crosson Cancer Center (TORI), Fullerton, California, United States
California Cancer Center, Inc, Greenbrae, California, United States
Wilshire Oncology Medical Group (TORI), Laverne, California, United States
Pacific Shores Medical Group (TORI), Long Beach, California, United States
UCLA Medical Center PVUB 3360, Los Angeles, California, United States
Central Hematology Oncology Medical Group (TORI), Monterey Park, California, United States
North Valley Hematology/Oncology Medical Group (TORI), Northridge, California, United States
Ventura County Hematology-Oncology Specialists (TORI), Oxnard, California, United States
Cancer Care Associates Medical Group (TORI), Redondo Beach, California, United States
UC Davis Cancer Center, Sacramento, California, United States
Kaiser Permanente/ San Diego, San Diego, California, United States
Sansum Santa Barbara Medical Foundation Clinic (TORI), Santa Barbara, California, United States
Santa Barbara Hematology Oncology Medical Group, Inc (TORI), Santa Barbara, California, United States
Kaiser Permanente Northern CA, Vallejo, California, United States
San Diego Cancer Center Medical Group (TORI), Vista, California, United States
Comprehensive Cancer Care Specialist at Boca Raton, Boca Raton, Florida, United States
Florida Cancer Specialists, Fort Myers, Florida, United States
The Florida Cancer Institute(TORI), Orlando, Florida, United States
MD Anderson Cancer Ctr- Orlando, Orlando, Florida, United States
Hematology and Oncology of Northeast Georgia, PC (TORI), Athens, Georgia, United States
Medical Oncology Associates, PC (TORI), Augusta, Georgia, United States
Suburban Hematology-Oncology Associates (TORI), Lawrenceville, Georgia, United States
WellStar Cancer Research Office, Marietta, Georgia, United States
Atlanta Cancer Care (TORI), Roswell, Georgia, United States
Rush-Presbyteriam, Chicago, Illinois, United States
University of Chicago, Chicago, Illinois, United States
Loyola Univ. Medical Center, Maywood, Illinois, United States
Hematology Oncology Consultants, Naperville, Illinois, United States
Oncoloy Hematology Associates of Central Illinois, PC (TORI), Peoria, Illinois, United States
Norton Healthcare Louisville Oncology, Louisville, Kentucky, United States
Ochsner Cancer Inst., New Orleans, Louisiana, United States
Maine Center for Cancer Medicine and Blood Disorders, Scarborough, Maine, United States
Methodist Cancer Center-Oncology Research, Omaha, Nebraska, United States
Comprehensive Cancer Centers of Nevada (TORI), Las Vegas, Nevada, United States
Summit Medical Group Overlook Oncology Center, Summit, New Jersey, United States
Cancer Research of Long Island, Great Neck, New York, United States
Northwestern Carolina Oncology and Hematology, Hickory, North Carolina, United States
Mid Dakota Clinic, Bismarck, North Dakota, United States
Earle A. Chiles Research Institute, Portland, Oregon, United States
Kaiser Permanente Northwest Region, Portland, Oregon, United States
Univ. of Pittsburgh Cancer Center Inst., Pittsburgh, Pennsylvania, United States
University of Tenn. Cancer Ins, Memphis, Tennessee, United States
The West Cancer Clinic, Memphis, Tennessee, United States
M.D. Anderson, Houston, Texas, United States
Virginia Mason Medical Center, Seattle, Washington, United States
Internal Medicine Associates of Yakima, Yakima, Washington, United States
Name: Vince O'Neill, M.D.
Affiliation: Genentech, Inc.
Role: STUDY_DIRECTOR