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Brief Title: Concordance of Key Actionable Genomic Alterations as Assessed in Tumor Tissue and Plasma in Non Small Cell Lung Cancer
Official Title: A Study to Determine the Concordance of Key Actionable Genomic Alterations as Assessed in Tumor Tissue and Plasma From Patients With Non Small Cell Lung Carcinoma (NSCLC)
Study ID: NCT02762877
Brief Summary: A study to determine the concordance of key actionable genomic alterations as assessed in tumor tissue and plasma from patients with non small cell lung carcinoma (NSCLC)
Detailed Description: This is a prospective clinical study to characterize the concordance of key clinically relevant genomic alterations in tumor tissue (biopsy/excision/cytology) and liquid biopsy (blood) using the Genomic Health LBMP in patients with stage IV non squamous NSCLC, that are either newly diagnosed with metastatic disease or progressing on therapy (any line). Tissue biopsy and blood collection (liquid biopsy) should be less than eight weeks apart and with no new systemic antitumoral treatment given in the interval between the tissue biopsy and blood collection. Local assessment of tumor tissue samples will be performed at each participating institution as per their clinical standard of care practices and results from the local assessment of genomic alteration status will be used.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Cancer Care Associates d/b/a Torrance Memorial Physician Network, Torrance, California, United States
Central Georgia Cancer Care, Macon, Georgia, United States
Virginia Piper Cancer Institute, Minneapolis, Minnesota, United States
Essex Oncology of North Jersey, Belleville, New Jersey, United States
Meridian Hospitals, Neptune, New Jersey, United States
Gabrail Cancer Center, Canton, Ohio, United States
West Clinic, Germantown, Tennessee, United States
Bon Secours Cancer Institute, Midlothian, Virginia, United States
MultiCare Health System, Tacoma, Washington, United States
Instituto Nacional del Torax, Santiago, , Chile
Fundaci贸n Arturo L贸pez Perez, Santiago, , Chile
Clinica Alemana de Santiago, Santiago, , Chile
Centre Jean Perrin, Clermont-Ferrand, Cedex 1, France
H么pital Nord, Marseille, Cedex 20, France
Polyclinique Bordeaux Nord Aquitaine, Bordeaux, , France
St. Vincent's University Hospital, Dublin, Elm Park, Ireland
Tokyo Medical University Hospital, Tokyo, Shinjuku-ku, Japan
National Cancer Center, Tokyo, Tsukiji, Chuo-ku, Japan
Hospital Universitario Central Asturias, Oviedo, , Spain
Hospital Universitario Virgen del Rocio, Sevilla, , Spain
Hospital Clinico Universitario Lozano Blesa, Zaragosa, , Spain
Clatterbridge Cancer Center NHS Foundation Trust, Bebington, Wirral, United Kingdom