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Spots Global Cancer Trial Database for Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer

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Trial Identification

Brief Title: Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer

Official Title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of ARQ197 Plus Erlotinib Versus Placebo Plus Erlotinib in Previously Treated Subjects With Locally Advanced or Metastatic, Non-Squamous, Non-Small-Cell Lung Cancer (NSCLC)

Study ID: NCT01244191

Conditions

Non Squamous, Non-small-cell Lung Cancer

Interventions

Tivantinib

Placebo

Erlotinib

Study Description

Brief Summary: This study is to determine if the combination regimen of tivantinib with erlotinib will improve overall survival relative to erlotinib alone in subjects with locally advanced or metastatic non-squamous, non-small cell lung cancer who have received 1 or 2 prior systemic anti-cancer therapies.

Detailed Description:

Keywords

Non squamous, non-small-cell lung cancer

Epidermal growth factor receptor

c-Met inhibitor

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

, Tucson, Arizona, United States

, Los Angeles, California, United States

, Oxnard, California, United States

, Rancho Mirage, California, United States

, Santa Monica, California, United States

, Aurora, Colorado, United States

, Boulder, Colorado, United States

, Colorado Springs, Colorado, United States

, Denver, Colorado, United States

, Lakewood, Colorado, United States

, Littleton, Colorado, United States

, Lone Tree, Colorado, United States

, Longmont, Colorado, United States

, Parker, Colorado, United States

, Thornton, Colorado, United States

, Newark, Delaware, United States

, Fort Myers, Florida, United States

, Miami Beach, Florida, United States

, Pensacola, Florida, United States

, Atlanta, Georgia, United States

, Austell, Georgia, United States

, Carrollton, Georgia, United States

, Cartersville, Georgia, United States

, Douglasville, Georgia, United States

, Marietta, Georgia, United States

, Chicago, Illinois, United States

, Carmel, Indiana, United States

, Fishers, Indiana, United States

, Goshen, Indiana, United States

, Greenfield, Indiana, United States

, Indianapolis, Indiana, United States

, Lexington, Kentucky, United States

, Louisville, Kentucky, United States

, Towson, Maryland, United States

, Boston, Massachusetts, United States

, Minneapolis, Minnesota, United States

, Saint Louis, Missouri, United States

, Grand Island, Nebraska, United States

, Omaha, Nebraska, United States

, Henderson, Nevada, United States

, Las Vegas, Nevada, United States

, East Orange, New Jersey, United States

, Albuquerque, New Mexico, United States

, Bronx, New York, United States

, Buffalo, New York, United States

, Goshen, New York, United States

, Latham, New York, United States

, New York, New York, United States

, Cincinnati, Ohio, United States

, Cleveland, Ohio, United States

, Kettering, Ohio, United States

, Eugene, Oregon, United States

, Portland, Oregon, United States

, Springfield, Oregon, United States

, Tualatin, Oregon, United States

, Harrisburg, Pennsylvania, United States

, Hershey, Pennsylvania, United States

, Philadelphia, Pennsylvania, United States

, Columbia, South Carolina, United States

, Easley, South Carolina, United States

, Greenville, South Carolina, United States

, Spartanburg, South Carolina, United States

, Bartlett, Tennessee, United States

, Chattanooga, Tennessee, United States

, Germantown, Tennessee, United States

, Knoxville, Tennessee, United States

, Memphis, Tennessee, United States

, Nashville, Tennessee, United States

, Southaven, Tennessee, United States

, Austin, Texas, United States

, Cedar Park, Texas, United States

, Dallas, Texas, United States

, Fort Worth, Texas, United States

, Kyle, Texas, United States

, Round Rock, Texas, United States

, San Marcos, Texas, United States

, Salt Lake City, Utah, United States

, Arlington, Virginia, United States

, Fairfax, Virginia, United States

, Gainesville, Virginia, United States

, Leesburg, Virginia, United States

, Midlothian, Virginia, United States

, Richmond, Virginia, United States

, Winchester, Virginia, United States

, Woodbridge, Virginia, United States

, Seattle, Washington, United States

, Vancouver, Washington, United States

, Yakima, Washington, United States

, Rosario, Santa Fe, Argentina

, Buenos Aires, , Argentina

, Cordoba, , Argentina

, San Miguel de Tucuman, , Argentina

, Tucuman, , Argentina

, Viedma, , Argentina

, Greenslopes, Queensland, Australia

, Camperdown, , Australia

, Kogarah, , Australia

, Perth, , Australia

, St. Leonards, , Australia

, Wollongong, , Australia

, Woodville, , Australia

, Salzburg, , Austria

, Wels, , Austria

, Brasschaat, , Belgium

, Brussels, , Belgium

, Duffel, , Belgium

, Salvador, BA, Brazil

, Rio de Janeiro, RJ, Brazil

, Passo Fundo, RS, Brazil

, Porto Alegre, RS, Brazil

, Joinville, Santa Catarina, Brazil

, Joinville, SC, Brazil

, Ijui, , Brazil

, Porto Alegre, , Brazil

, Sao Paulo, , Brazil

, Edmonton, Alberta, Canada

, Surrey, British Columbia, Canada

, Victoria, British Columbia, Canada

, Winnipeg, Manitoba, Canada

, London, Ontario, Canada

, Thunder Bay, Ontario, Canada

, Toronto, Ontario, Canada

, Montreal, Quebec, Canada

, Montreal, , Canada

, Quebec, , Canada

, Toronto, , Canada

, Santiago, , Chile

, Ostrava, , Czechia

, Pardubice, , Czechia

, Praha, , Czechia

, Usti nad Labem, , Czechia

, Herlev, , Denmark

, Naestved, , Denmark

, Odense, , Denmark

, Besancon, , France

, Brest, , France

, Caen Cedex, , France

, Grenoble, , France

, Lille, , France

, Marseille Cedex, , France

, Paris Cedex, , France

, Paris, , France

, Pierre Benite, , France

, Rennes Cedex, , France

, Saint-Priest en Jarez, , France

, Strasbourg Cedex, , France

, Toulouse Cedex, , France

, Tours Cedex, , France

, Villejuif, , France

, Bad Berka, , Germany

, Berlin, , Germany

, Erfurt, , Germany

, Essen, , Germany

, Esslingen, , Germany

, Gauting, , Germany

, Großhansdorf, , Germany

, Halle, , Germany

, Hamburg, , Germany

, Hannover, , Germany

, Karlsruhe, , Germany

, Kassel, , Germany

, Koln, , Germany

, Leverkusen, , Germany

, Lowenstein, , Germany

, Mainz, , Germany

, Mannheim, , Germany

, Munchen, , Germany

, Porta Westfalica, , Germany

, Rheine, , Germany

, Villingen-Schwenningen, , Germany

, Deszk, , Hungary

, Gyula, , Hungary

, Matrahaza, , Hungary

, Szekesfehervar, , Hungary

, Szolnok, , Hungary

, Ancona, , Italy

, Avellino, , Italy

, Aviano, , Italy

, Bari, , Italy

, Catania, , Italy

, Cremona, , Italy

, Cuneo, , Italy

, Firenze, , Italy

, Livorno, , Italy

, Milano, , Italy

, Modena, , Italy

, Monza, , Italy

, Napoli, , Italy

, Novara, , Italy

, Orbassano, , Italy

, Padova, , Italy

, Palermo, , Italy

, Parma, , Italy

, Perugia, , Italy

, Roma, , Italy

, Rozzano, , Italy

, Sassari, , Italy

, Sondalo, , Italy

, Sora, , Italy

, Torino, , Italy

, Mexico, DF, Mexico

, Monterrey, Nuevo Leon, Mexico

, Guadalajara, , Mexico

, Mexico City, , Mexico

, Oaxaca, , Mexico

, Enschede, ER, Netherlands

, Helmond, HA, Netherlands

, Amsterdam, , Netherlands

, Arequipa, , Peru

, Lima, , Peru

, Bystra, , Poland

, Krakow, , Poland

, Lublin, , Poland

, Olsztyn, , Poland

, Opole, , Poland

, Poznan, , Poland

, Prabuty, , Poland

, Rzeszow, , Poland

, Szczecin, , Poland

, Torun, , Poland

, Walbrzych, , Poland

, Cluj-Napoca, , Romania

, Craiova, , Romania

, Oradea, , Romania

, Chelyabinsk, , Russian Federation

, Irkutsk, , Russian Federation

, Izhevsk, , Russian Federation

, Kursk, , Russian Federation

, Moscow, , Russian Federation

, Novgorod, , Russian Federation

, Novosibirsk, , Russian Federation

, Pyatigorsk, , Russian Federation

, St Petersburg, , Russian Federation

, St. Petersburg, , Russian Federation

, Tula, , Russian Federation

, Tyumen, , Russian Federation

, Barakaldo, Bilbao, Spain

, Vigo, Pontevedra, Spain

, Alicante, , Spain

, Barcelona, , Spain

, Coruna, , Spain

, La Laguna, , Spain

, Madrid, , Spain

, Malaga, , Spain

, Manresa, , Spain

, Oviedo, , Spain

, Palma de Mallorca, , Spain

, Sabadell, , Spain

, Santiago de Compostela, , Spain

, Sevilla, , Spain

, Valencia, , Spain

, Zaragoza, , Spain

, Linkoping, , Sweden

, Lund, , Sweden

, Guildford, Surrey, United Kingdom

, Aberdeen, , United Kingdom

, Glasgow, , United Kingdom

, London, , United Kingdom

, Manchester, , United Kingdom

, Nottingham, , United Kingdom

, Sheffield, , United Kingdom

Contact Details

Name: Global Clinical Leader

Affiliation: Daiichi Sankyo

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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