Spots Global Cancer Trial Database for Paclitaxel-bevacizumab in Advanced Lung Cancer
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Trial Identification
Brief Title: Paclitaxel-bevacizumab in Advanced Lung Cancer
Official Title: Phase III Study Comparing the Efficacy of Paclitaxel-bevacizumab With Docetaxel in 2nd or 3rd Line of Treatment of Non Squamous Non Small Cells Lung Cancer
Study ID: NCT01763671
Conditions
Study Description
Brief Summary: The study objective is to evaluate the efficacy of paclitaxel-bevacizumab comparing to docetaxel. Docetaxel is a standard treatment of 2nd or 3rd line in lung cancer. It was validated by numerous clinical trials but sometimes toxicities are difficult to manage. Bevacizumab is an antiangiogenic treatment which was validated by numerous clinical trials in association with platinum in first ligne. Different clinical and preclinical data suggest that there could exist a synergy between paclitaxel and bevacizumab. This association is already used in metastatic breast cancer, it permits almost to double the response rate and progression free survival. In lung cancer, the association was evaluated by two retrospective studies which demonstrated a benefit with a favourable safety profile.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Amiens - CHU, Amiens, , France
Centre Hospitalier, Annemasse, , France
Hôpital Privé d'Antony, Antony, , France
Avignon - Institut Sainte-Catherine, Avignon, , France
CH de la Côte Basque, Bayonne, , France
Bordeaux - Polyclinique Nord, Bordeaux, , France
Béziers - CH, Béziers, , France
Caen - Centre François Baclesse, Caen, , France
Caen - CHU Côte de Nacre, Caen, , France
Castelnau Le Lez - Clinique, Castelnau, , France
CH de Chartres Hôpital Louis Pasteur, Chartres, , France
Chauny - CH, Chauny, , France
CH, Cholet, , France
Hôpital Percy-Armées - Pneumologie, Clamart, , France
Hôpitral Gabriel Montpied - Pneumologie, Clermont-Ferrand, , France
CH, Colmar, , France
CH Compiègne - Pneumologie, Compiègne, , France
CHI Créteil, Créteil, , France
CHRU Grenoble, Grenoble, , France
Harfleur - Clinique du Petit Colmoulins, Harfleur, , France
CH Région Saint-Omer, Helfaut, , France
Le Mans - Centre Hospitalier, Le Mans, , France
CHU (Hôpital Calmette) - Pneumologie, Lille, , France
CH de Longjumeau, Longjumeau, , France
Lorient - CHBS, Lorient, , France
Lyon - Hôpital Jean Mermoz, Lyon, , France
Lyon - Hôpital Louis Pradel (Pneumologie), Lyon, , France
CH de Macon, Macon, , France
Mantes La Jolie - CH, Mantes La Jolie, , France
Marseille - Hôpital Sainte Marguerite, Marseille, , France
Maubeuge - Polyclinique du Parc, Maubeuge, , France
CH Montélimar, Montélimar, , France
Mulhouse - CH, Mulhouse, , France
Nantes - Centre René Gauducheau, Nantes, , France
CHR d'Orléans La Source, Orléans, , France
Paris - Saint Louis, Paris, , France
Hopital Tenon - Pneumologie, Paris, , France
HIA Val-de-Grâce, Paris, , France
Hôpital Bichat - Claude - Bernard, Paris, , France
Paris - Pitié-salpêtrière, Paris, , France
Pau - CH, Pau, , France
Lyon Sud, Pierre Bénite, , France
Rouen - CHU, Rouen, , France
Saint Quentin - CH, Saint Quentin, , France
CHU Saint-Etienne Pneumologie, Saint-Etienne, , France
Strasbourg - NHC, Strasbourg, , France
Suresnes - Hopital Foch, Suresnes, , France
Thonon les bains - CH, Thonon les bains, , France
Toulon - CHI, Toulon, , France
Toulon - HIA, Toulon, , France
Toulouse - CHU Larrey, Toulouse, , France
Tours - CHU, Tours, , France
Valenciennes - Clinique, Valenciennes, , France
CH de Villefranche - Pneumologie, Villefranche, , France
Institut Gustave Roussy, Villejuif, , France
Contact Details
Name: Alexis CORTOT, MD
Affiliation: CHRU Lille
Role: PRINCIPAL_INVESTIGATOR
Name: Benjamin BESSE, MD
Affiliation: Gustave Roussy, Cancer Campus, Grand Paris
Role: PRINCIPAL_INVESTIGATOR
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