Spots Global Cancer Trial Database for Optimization of Novel DCE-MRI Imaging Sequences for Cancer Therapy Monitoring

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Trial Identification

Brief Title: Optimization of Novel DCE-MRI Imaging Sequences for Cancer Therapy Monitoring

Official Title: Optimization of Novel DCE-MRI Imaging Sequences for Cancer Therapy Monitoring

Study ID: NCT01752231

Conditions

Normal Volunteers

Interventions

Study Description

Brief Summary: This pilot clinical trial studies dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI) in diagnosing cancer. New diagnostic procedures, such as DCE-MRI may help find and diagnose cancer

Detailed Description: PRIMARY OBJECTIVES: I. Optimize and develop functional DCE-MRI pulse sequences, which involve the injection of MRI-visible contrast agents, for imaging in the head/neck, abdominal and pelvic regions. II. Determine the ideal radiofrequency (RF) coil setup to maximize signal to noise ratio of the optimized pulse sequences. III. Distill the findings of specific aims 1 and 2 into streamlined protocols that can be used in subsequent studies for cancer phenotyping and treatment monitoring in a quantitative manner. IV. To establish a virtual reference image repository for future studies. OUTLINE: Patients undergo DCE-MRI over approximately 30-60 minutes consisting of an anatomical scout image to localize the region of interest, a set of pre-injection scans to calibrate the dynamic image set, a dynamic image set during which contrast agent will be injected, and a set of post-injection scans to calibrate the DCE-MRI database.