Spots Global Cancer Trial Database for Phase-II Trial of Induction Chemotherapy and Chemoradiotherapy Plus/Minus Durvalumab and Consolidation Immunotherapy in Patients With Resectable Stage III NSCLC.
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Trial Identification
Brief Title: Phase-II Trial of Induction Chemotherapy and Chemoradiotherapy Plus/Minus Durvalumab and Consolidation Immunotherapy in Patients With Resectable Stage III NSCLC.
Official Title: Prospective Phase-II Trial of Induction Chemotherapy and Chemoradiotherapy Plus/Minus the PD-L1 Antibody Durvalumab Followed by Surgery or Definitive Chemoradiation Boost and Consolidation Durvalumab in Resectable Stage III NSCLC.
Study ID: NCT04202809
Conditions
Interventions
Study Description
Brief Summary: To compare a complex induction multimodality protocol (ESPATUE) + concurrent immunotherapy with PD-L1 antibody Durvalumab given every three weeks to the same induction multimodality protocol without Durvalumab immunotherapy induction followed by definitive local treatment (surgery for those considered resectable or chemoradiation boost for those not considered to be R0-resectable) followed by consolidation Durvalumab treatment in both arms.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Klinikum rechts der Isar - Technische Universität München, Munich, Bavaria, Germany
Universitätsklinikum Essen, Essen, , Germany
Universitätsklinikum Freiburg, Freiburg, , Germany
Lungenklinik Hemer Deutscher Gemeinschafts-Diakonieverband GmbH, Hemer, , Germany
Pius-Hospital Oldenburg, Oldenburg, , Germany
Universitätsklinikum Regensburg, Regensburg, , Germany
Robert-Bosch-Krankenhaus, Stuttgart, , Germany
Contact Details
Name: Wilfried Eberhardt, PD MD
Affiliation: University Hospital, Essen
Role: PRINCIPAL_INVESTIGATOR
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