Spots Global Cancer Trial Database for Advancing Brigatinib Properties in ALK+ NSCLC Patients by Deep Phenotyping
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Trial Identification
Brief Title: Advancing Brigatinib Properties in ALK+ NSCLC Patients by Deep Phenotyping
Official Title: Advancing Brigatinib Properties in Anaplastic Lymphoma Kinase Positive Non-small Cell Lung Cancer (ALK+ NSCLC) Patients
Study ID: NCT04318938
Conditions
Study Description
Brief Summary: This is a prospective, randomized, open-label, multicenter phase II study investigating the advancing Brigatinib properties in anaplastic lymphoma kinase positive non-small cell lung cancer (ALK+ NSCLC) patients by deep phenotyping
Detailed Description: The aim of this study is to compare efficacy of brigatinib and other 2nd-generation ALK tyrosin kinase inhibitor (TKI) in 1st and 2nd line treatment and to explore resistance patterns according to treatment and molecular properties of the tumors
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
HELIOS Klinikum Emil von Behring, Berlin, , Germany
Charité Berlin, Berlin, , Germany
UniversitÀtsmedizin Essen, Essen, , Germany
Klinikum Esslingen, Esslingen, , Germany
Krankenhaus Nordwest Frankfurt, Frankfurt am main, , Germany
UniversitÀtsklinikum Freiburg, Freiburg, , Germany
Niels-Stensen-Kliniken GeorgsmarienhĂŒtte, GeorgsmarienhĂŒtte, , Germany
UniversitĂ€tsklinikum GieĂen, GieĂen, , Germany
Studiengesellschaft HĂ€mato-Onkologie Hamburg, Hamburg, , Germany
Evangelisches Krankenhaus Hamm, Hamm, , Germany
KRH Klinikum Siloah Hannover, Hannover, , Germany
Medizinische Hochschule Hannover, Hannover, , Germany
Thoraxklinik am UniversitÀtsklinikum Heidelberg, Heidelberg, , Germany
Lungenklinik Hemer, Hemer, , Germany
UniversitÀtsklinikum Jena, Jena, , Germany
Lungenklinik Köln - Merheim, Köln, , Germany
UniversitÀtsklinikum Leipzig, Leipzig, , Germany
UniversitÀtsmedizin Mainz, Mainz, , Germany
Klinik der LMU MĂŒnchen - Innenstadt, MĂŒnchen, , Germany
UniversitĂ€tsklinikum MĂŒnster, MĂŒnster, , Germany
Klinikum NĂŒrnberg, NĂŒrnberg, , Germany
Pius Hospital Oldenburg, Oldenburg, , Germany
UniversitÀtsklinikum Regensburg, Regensburg, , Germany
Klinik Schillerhöhe, Stuttgart, , Germany
UniversitÀtsklinikum Ulm, Ulm, , Germany
UniversitĂ€tsklinikum WĂŒrzburg, WĂŒrzburg, , Germany
Contact Details
Name: Salah-Eddin Al-Batran, Prof.
Affiliation: Institut fĂŒr Klinische Krebsforschung IKF GmbH
Role: STUDY_DIRECTOR
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