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Brief Title: Molecular Monitoring of cfDNA by ddPCR in Non-small Cell Lung Cancer Treated by Immunotherapy.
Official Title: Molecular Monitoring of cfDNA by ddPCR in Non-small Cell Lung Cancer Treated by Immunotherapy.
Study ID: NCT04720339
Brief Summary: Non-small cell lung cancer (NSCLC) is a major public health problem. New treatments as immunotherapy can improve prognosis of patients with NCLC tumors. Nevertheless, no robust biomarker is actually available. The hypothesis of the trial is to realize a longitudinal molecular monitoring of NSCLC patients treated by immunotherapy using a quantitative analysis of cell-free DNA. The primary purposes is to study the predictive value of quantification of cell-free DNA at the first reevaluation time, on the clinical benefit, in NSCLC patients treated by immunotherapy (regardless of line, or associated treatments) The secondary purposes in this population of patients is to study the earlier predictive value (before the second treatment by immunotherapy ) of quantification of cell-free DNA, and its relationship with refractory disease and pseudo-progressive disease.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
CHU de Besancon - Service de pneumologie, Besançon, , France
Hopitaux Civils de Colmar - service de Pneumologie, Colmar, , France
CHU de Dijon - service de Pneumologie, Dijon, , France
CLCC Georges-François Leclerc, Dijon, , France
GHR Mulhouse Sud-Alsace - Service de Pneumologie, Mulhouse, , France
CHU de Reims - service de Pneumologie, Reims, , France
CHRU de Strasbourg, Strasbourg, , France
Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, , France