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Spots Global Cancer Trial Database for Molecular Monitoring of cfDNA by ddPCR in Non-small Cell Lung Cancer Treated by Immunotherapy.

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Trial Identification

Brief Title: Molecular Monitoring of cfDNA by ddPCR in Non-small Cell Lung Cancer Treated by Immunotherapy.

Official Title: Molecular Monitoring of cfDNA by ddPCR in Non-small Cell Lung Cancer Treated by Immunotherapy.

Study ID: NCT04720339

Study Description

Brief Summary: Non-small cell lung cancer (NSCLC) is a major public health problem. New treatments as immunotherapy can improve prognosis of patients with NCLC tumors. Nevertheless, no robust biomarker is actually available. The hypothesis of the trial is to realize a longitudinal molecular monitoring of NSCLC patients treated by immunotherapy using a quantitative analysis of cell-free DNA. The primary purposes is to study the predictive value of quantification of cell-free DNA at the first reevaluation time, on the clinical benefit, in NSCLC patients treated by immunotherapy (regardless of line, or associated treatments) The secondary purposes in this population of patients is to study the earlier predictive value (before the second treatment by immunotherapy ) of quantification of cell-free DNA, and its relationship with refractory disease and pseudo-progressive disease.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

CHU de Besancon - Service de pneumologie, Besançon, , France

Hopitaux Civils de Colmar - service de Pneumologie, Colmar, , France

CHU de Dijon - service de Pneumologie, Dijon, , France

CLCC Georges-François Leclerc, Dijon, , France

GHR Mulhouse Sud-Alsace - Service de Pneumologie, Mulhouse, , France

CHU de Reims - service de Pneumologie, Reims, , France

CHRU de Strasbourg, Strasbourg, , France

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, , France

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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