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Spots Global Cancer Trial Database for Registry for Molecular Testing, Treatment and Outcome of Patients With Solid Tumors Harboring a NTRK Gene Fusion

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Trial Identification

Brief Title: Registry for Molecular Testing, Treatment and Outcome of Patients With Solid Tumors Harboring a NTRK Gene Fusion

Official Title: Registry for Molecular Testing, Treatment and Outcome of Patients With Locally Advanced or Metastatic Solid Tumors Harboring a Fusion of NTRK1, NTRK2 or NTRK3

Study ID: NCT04557813

Interventions

Study Description

Brief Summary: The objective of this registry is to analyze treatment reality and outcome of patients with locally advanced or metastatic solid tumors harboring a fusion of NTRK1, NTRK2 or NTRK3

Detailed Description: The REALTRK registry will provide data on treatment reality of patients with locally advanced or metastatic solid tumors harboring NTRK1, NTRK2 or NTRK3 gene fusions, thereby generating real world evidence. It will identify factors that influence treatment decisions after receiving the diagnosis of a NTRK (Neurotrophic Tyrosine Receptor Kinase) fusion-positive cancer. All treatment lines administered before and after the molecular diagnosis of a NTRK fusion-positive cancer, irrespective of the type of antineoplastic treatment, will be documented. Data will be assessed at least 36 months per patient (i.e. until 36 months after inclusion of the last patient in the study). This approach will allow a description of TRK fusion protein-targeted therapies and other therapy strategies regarding effectiveness and disease-related symptomology within the limitations of non-randomized studies in terms of comparative analyses. Intra-individual and inter-individual comparisons (for the latter, provided that a sufficient number of patients with a NTRK fusion-positive cancer are not treated with a TRK inhibitor) could be performed. The associated biomarker profiling module of the REALTRK registry will aim to set up a decentralized biobank for future research on molecular alterations.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Onkologische Schwerpunktpraxis KurfĂźrstendamm, Berlin, , Germany

Centrum fßr Hämatologie und Onkologie Bethanien, Frankfurt, , Germany

Praxis fßr interdisziplinäre Onkologie & Hämatologie, Freiburg, , Germany

Asklepios Klinik Altona, Hamburg, , Germany

Onkologische Schwerpunktpraxis, Hannover, , Germany

Gemeinschaftspraxis, Hannover, , Germany

SLK Kliniken Heilbronn Klinik fĂźr Innere Medizin III, Heilbronn, , Germany

Klinikum Kempten, Kempten, , Germany

PIOH - Praxis Internistische Onkologie und Hämatologie, KÜln, , Germany

Asklepios MVZ Bayern, Schwerpunkt Hämatologie/Onkologie, Landsberg, , Germany

Onkologische Praxis am Marien-Krankenhaus, LĂźbeck, , Germany

Praxis fĂźr Onkologie, MĂśnchengladbach, , Germany

Klinikum rechts der Isar der TUM Innere Medizin II, MĂźnchen, , Germany

Universitätsklinikum Mßnster, Medizinische Klinik A, Mßnster, , Germany

TZN - Tumorzentrum Niederrhein GmbH, Neuss, , Germany

Studienzentrum Onkologie Ravensburg, Ravensburg, , Germany

Praxis und Tagesklinik fßr Onkologie und Hämatologie, Recklinghausen, , Germany

Klinikum Rosenheim, Rosenheim, , Germany

Zentrum Ambulante Onkologie, Schorndorf, , Germany

MVZ Kloster Paradiese GbR, Soest, , Germany

MVZ fßr Hämatologie und Onkologie, Ulm, , Germany

Onkologie Schwarzwald-Alb, Villingen-Schwenningen, , Germany

Universitätsspital Basel, Basel, , Switzerland

Contact Details

Name: Benjamin Kasenda, PD Dr. Dr.

Affiliation: Universitätsspital Basel, Petersgraben 4, 4031 Basel, Switzerland

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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