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Spots Global Cancer Trial Database for Understanding immunE-related toXicities by multifACeT Profiling

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Trial Identification

Brief Title: Understanding immunE-related toXicities by multifACeT Profiling

Official Title: EXACT - Understanding immunE-related toXicities by multifACeT Profiling

Study ID: NCT05331066

Conditions

Oncology

Interventions

Study Description

Brief Summary: A prospective observational cohort study of patients undergoing CPI therapy in which translational research is the fundamental aspect of the study.

Detailed Description: The study aims to enroll and obtain samples of investigational interest from 200 patients over a 36-month recruitment period. Blood and/ or stool samples will be taken at baseline, in context of irAE development / during CPI treatment and during follow-up. Skin samples may also be taken upon development of organspeciifc irAEs. Further assessments at baseline or during the course of or following treatment will be conducted in accordance with standard institutional practice and will be clinically driven. Clinical data, samples and results from archival, current or prospective diagnostic or therapeutic procedures will be used for research purposes within EXACT. IrAE clinical monitoring will be conducted in accordance with standard institutional practice and will be clinically driven.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom

Contact Details

Name: Samra Turajlic

Affiliation: Royal Marsden NHS Foundation Trust

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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