Spots Global Cancer Trial Database for Modeling of the Response to Hypofractionated Stereotactic Pulmonary Irradiation

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Trial Identification

Brief Title: Modeling of the Response to Hypofractionated Stereotactic Pulmonary Irradiation

Official Title: Multiscale Modeling / Simulation of the Response to Pulmonary Stereotactic Hypofractionated Irradiation

Study ID: NCT03175861

Conditions

Oncology

Interventions

Stereotactic radiotherapy

Study Description

Brief Summary: Identify 18-Fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) parameters predictive of tumor response and local control

Detailed Description: The identification of robust prognostic and predictive markers could allow the individualization of pulmonary stereotactic radiotherapy treatments and the selection of patients at high risk of relapse, who could then benefit from a dose escalation in order to increase the chances of local control . Beyond the pulmonary RTS (Radiotherapy in stereotactic condition), this study will aim to generate one or more models of multi-scale response to hypofractionated irradiation from biomarkers (biological or images) extracted from preclinical or clinical literature data and to allow simulations of Various modified fractionation irradiation schemes, potentially leading to new regimens that reduce side effects and increase therapeutic efficacy.