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Brief Title: Oral Assessment of Symptoms in Advanced Cancer
Official Title: An Observational Study of the Frequency of Oral Symptoms in Patients With Advanced Cancer
Study ID: NCT04404920
Brief Summary: Observational study of prevalence of oral symptoms in patients with advanced cancer using a novel questionnaire ("Oral symptom assessment scale")
Detailed Description: A novel questionnaire (the "Oral symptom assessment scale" / OSAS) has been developed to assess a range of oral symptoms in patients with advanced cancer. The OSAS consists of 20 symptoms, which were chosen following a review of the literature / discussion with experts in the field. The OSAS was modelled on the Memorial Symptom Assessment Scale (MSAS), and asks about the presence of the symptoms, the frequency of the symptoms (i.e. "rarely"; "occasionally"; "frequently"; or "almost constantly"), the severity of the symptoms (i.e. "slight"; "moderate"; "severe"; or "very severe"), and how much distress they cause (i.e. "not at all"; "a little bit"; "somewhat"; "quite a bit"; or "very much"). The questions relate to the last week. Patients will be given the OSAS to complete, and also the short form of the MSAS (which asks about the presence, and related distress, of 32 physical / psychological symptoms, including a small number of oral symptoms). Demographic data, cancer diagnosis, and performance status will also be collected. The study involves a single visit / assessment. Descriptive statistics will be used to present the data, and hierarchical cluster analysis will be used to identify oral symptom clusters. Kappa tests will be used to compare analogous questions on the OSAS and short form MSAS (as part of the validation of the OSAS).
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Brighton & Sussex University Hospitals, Brighton, East Sussex, United Kingdom
East Sussex Healthcare NHS Trust, Eastbourne, East Sussex, United Kingdom
Pilgrims Hospice, Margate, Kent, United Kingdom
Ellenor Lions Hospice, Northfleet, Kent, United Kingdom
Hospice in the Weald, Pembury, Kent, United Kingdom
Wisdom Hospice, Rochester, Kent, United Kingdom
Frimley Park Hospital, Camberley, Surrey, United Kingdom
Princess Alice Hospice, Esher, Surrey, United Kingdom
Royal Surrey County Hospital, Guildford, Surrey, United Kingdom
St. Wilfred's Hospice, Chichester, Wesr Sussex, United Kingdom
St. Catherine's Hospice, Crawley, West Sussex, United Kingdom
Name: Andrew Davies, MD
Affiliation: Royal Surrey County Hospital NHS Foundation Trust
Role: PRINCIPAL_INVESTIGATOR