Spots Global Cancer Trial Database for CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)
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Trial Identification
Brief Title: CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)
Official Title: Phase III Randomised Controlled Trial Comparing Alternative Regimens for Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer
Study ID: NCT04116047
Conditions
Study Description
Brief Summary: CompARE is a multicentre, phase III open-label randomised controlled trial using an adaptive, Multi-Arm, Multi-Stage (MAMS) design.
Detailed Description: The CompARE Trial examines alternative regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer in an adult patient population. The aim is to assess whether escalated radiotherapy, adding surgery or immunotherapy will improve overall survival and quality of life in these patients.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
St Luke's Hospital, Dublin, , Ireland
St James's Hospital, Dublin, , Ireland
Royal Devon and Exeter Hospital, Exeter, Devon, United Kingdom
Leicester Royal Infirmary, Leicester, East Midlands, United Kingdom
Castle Hill Hospital, Cottingham, East Yorkshire, United Kingdom
Colchester General Hospital, Colchester, Essex, United Kingdom
Queen's Hospital, Romford, Essex, United Kingdom
Royal Preston Hospital, Preston, Lancashire, United Kingdom
James Cook University Hospital, Middlesbrough, North Yorkshire, United Kingdom
York Hospital, York, North Yorkshire, United Kingdom
Churchill Hospital, Oxford, Oxfordshire, United Kingdom
Weston Park Hospital, Sheffield, South Yorkshire, United Kingdom
Freeman Hospital, Newcastle Upon Tyne, Tyne And Wear, United Kingdom
Queen Elizabeth Hospital, Birmingham, West Midlands, United Kingdom
University Hospital Coventry, Coventry, West Midlands, United Kingdom
Newcross Hospital, Wolverhampton, West Midlands, United Kingdom
Bradford Royal Infirmary, Bradford, West Yorkshire, United Kingdom
St James's University Hospital, Leeds, West Yorkshire, United Kingdom
Aberdeen Royal Infirmary, Aberdeen, , United Kingdom
Royal United Hospital, Bath, , United Kingdom
Belfast City Hospital, Belfast, , United Kingdom
Bristol Haematology and Oncology Centre, Bristol, , United Kingdom
Addenbrooke's Hospital, Cambridge, , United Kingdom
Velindre Cancer Centre, Cardiff, , United Kingdom
Cheltenham General Hospital, Cheltenham, , United Kingdom
Western General Hospital, Edinburgh, , United Kingdom
Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Aintree University Hospital, Liverpool, , United Kingdom
North Middlesex Hospital, London, , United Kingdom
Christie Hospital, Manchester, , United Kingdom
Norfolk and Norwich University Hospital, Norwich, , United Kingdom
Nottingham City Hospital, Nottingham, , United Kingdom
Derriford Hospital, Plymouth, , United Kingdom
Royal Shrewsbury Hospital, Shrewsbury, , United Kingdom
Singleton Hospital, Swansea, , United Kingdom
Musgrove Park Hospital, Taunton, , United Kingdom
Torbay Hospital, Torquay, , United Kingdom
Clatterbridge Cancer Centre, Wirral, , United Kingdom
Contact Details
Name: Prof Mehanna
Affiliation: University of Birmingham
Role: PRINCIPAL_INVESTIGATOR
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