Spots Global Cancer Trial Database for Proteomics Research of Osteosarcoma
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Trial Identification
Brief Title: Proteomics Research of Osteosarcoma
Official Title: Establishment of New Molecular Prototyping Based on Proteomics for Predicting Osteosarcoma Chemotherapy Response and Risk of Recurrence
Study ID: NCT03932058
Interventions
Study Description
Brief Summary: Retrospectively collected 400 cases of clinical data and pathological paraffin specimens of osteosarcoma, chondrosarcoma (control) and endogenous chondroma (control) in our hospital from 2008 to 2014, combined with high-pressure cycle-satellite scanning mass spectrometry (PCT-SWATH) Molecular typing of osteosarcoma and prediction of targeted therapy, the establishment of a new molecular classification based on proteomics for osteosarcoma to predict the chemotherapy response and recurrence risk of osteosarcoma. Clinical osteosarcoma patients include as many types as possible: pre-chemotherapy, post-chemotherapy, recurrence, and metastasis. The study did not involve vulnerable groups, and it was taken as a postoperative wax specimen for patients, which had no health, life and other effects on patients. Study application exemption from informed consent.
Detailed Description:
Keywords
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
2nd Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China
Contact Details
Name: zhaoming Ye, Prof.
Affiliation: 2nd Affiliated Hospital Of Zhejiang University
Role: PRINCIPAL_INVESTIGATOR
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