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Brief Title: Sorafenib in Relapsed High Grade Osteosarcoma
Official Title: Phase II, Open Label, Non-randomized Study of Second or Third Line Treatment With Sorafenib (BAY 43-9006) in Patients Affected by Relapsed High-grade Osteosarcoma.
Study ID: NCT00889057
Brief Summary: Aim of this exploratory phase II study is to assess the clinical activity of sorafenib as single agent, in terms of percentage of patients with high grade advanced osteosarcoma free from progression following 4 months of therapy
Detailed Description:
Minimum Age: 15 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
I.R.C.C. - Unit of Medical Oncology, Candiolo, Torino, Italy
Istituti Ortopedici Rizzoli - Unit of Chemotherapy of Muscoloskeletal Tumors, Bologna, , Italy
Istituto Nazionale Tumori - Unit of Medical Oncology, Milano, , Italy
Ospedale Infantile Regina Margherita - Unit of Paediatric Oncoematology, Torino, , Italy
Name: Massimo Aglietta, MD
Affiliation: I.R.C.C - FPO Candiolo
Role: STUDY_CHAIR
Name: Giovanni Grignani, MD
Affiliation: I.R.C.C. - FPO Candiolo
Role: PRINCIPAL_INVESTIGATOR