Spots Global Cancer Trial Database for Pilot Study of Curcumin Formulation and Ashwagandha Extract in Advanced Osteosarcoma

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Trial Identification

Brief Title: Pilot Study of Curcumin Formulation and Ashwagandha Extract in Advanced Osteosarcoma

Official Title: Evaluation of Curcumin Formulation, and Ashwagandha Root Powder Extract in the Management of Advanced High Grade Osteosarcoma"

Study ID: NCT00689195

Conditions

Osteosarcoma

Interventions

Curcumin powder

Ashwagandha extract

Study Description

Brief Summary: Curcumin as well as the ashwagandha extract are ingredients from traditional indian medicine and have been shown to be potent anti-cancer compounds in laboratory as well as animal studies. This study will test the safety and efficacy of a curcumin formulation and the ashwagandha extract in high grade relapsed or metastatic osteosarcoma where no other second line chemotherapy is being given. The pharmacokinetics will be studied along with response as measured on CT scans and PET scans as well as the quality of life and any toxicity.

Detailed Description: Eligibility criteria 1. Osteosarcoma which has relapsed after treatment and for which no second line chemotherapy is planned and in which disease is not amenable to surgery. 2. Patient should be able to follow-up 3 monthly for clinical and imaging assessment as well as biochemical tests