Spots Global Cancer Trial Database for SUV PDL1/PD1 in Sun Damaged & Sun Protected Human Skin of Participants

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Trial Identification

Brief Title: SUV PDL1/PD1 in Sun Damaged & Sun Protected Human Skin of Participants

Official Title: An Assessment of Acute Solar UV-induced PD-L1/PD1 Expression in Sun Damaged & Sun Protected Human Skin of Participants With and Without History of SCC

Study ID: NCT06177106

Conditions

Other Skin Changes Due to Chronic Exposure to Nonionizing Radiation

Interventions

Solar Simulated Light

Study Description

Brief Summary: The purpose of this research study is to look at how the proteins and genes in people's skin change when they're exposed to simulated sunlight. The researchers want to see if there are differences between people who've had skin cancer and those who haven't despite having a similar type of skin and history of sun exposure. Since this study is designed to simulate sun exposure to small areas of skin, mild to moderate sunburn and tanned spots at the site of the simulated sunlight exposure is a risk. In addition to simulated sun exposure, patients will also have four 6 mm punch skin biopsies performed. Brief discomfort may be felt when the local painkiller (lidocaine) is injected prior to skin biopsies; however, it is usually minimal. Participation in the study involves 4 visits to the clinic over the course of 4 weeks. Each visit will take no longer than 90 minutes.

Detailed Description: