Spots Global Cancer Trial Database for ASA in Prevention of Ovarian Cancer (STICs and STONEs)
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Trial Identification
Brief Title: ASA in Prevention of Ovarian Cancer (STICs and STONEs)
Official Title: A Randomized Phase II Double-Blind Placebo-Controlled Trial of Acetylsalicylic Acid (ASA) in Prevention of Ovarian Cancer in Women With BRCA 1/2 Mutations (STICs and STONEs)
Study ID: NCT03480776
Conditions
Study Description
Brief Summary: While ASA is not a cancer medication, research suggests that taking ASA reduces the probability of getting many types of cancer because of its anti-inflammatory action. Inflammation in the ovaries during ovulation is thought to contribute to the development of ovarian cancer, and, because ASA is an anti-inflammatory medication, it may help to prevent it.
Detailed Description: The standard or usual treatment for women with a high risk gene mutation, BRCA1 or BRCA2, is to have risk-reducing surgery to remove the fallopian tubes and ovaries (bilateral salpingo-oophorectomy or bilateral salpingectomy inclusive of fimbria) after they have decided not to have more children naturally. Acetylsalicylic Acid (ASA) is a safe, well tolerated drug taken by mouth. ASA has been available for over 100 years and has been used mainly to relieve fever and pain, but also as an anti-inflammatory medication in order to reduce inflammation (swelling).
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: Yes
Locations
Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Prince of Wales Hospital, Randwick, New South Wales, Australia
Westmead Hospital, Westmead, New South Wales, Australia
Peter McCallum Cancer Institute, Melbourne, Victoria, Australia
King Edward Memorial Hospital, Subiaco, Western Australia, Australia
St John of God Subiaco, Subiaco, Western Australia, Australia
Tom Baker Cancer Centre, Calgary, Alberta, Canada
Clinical Research Unit at Vancouver Coastal, Vancouver, British Columbia, Canada
CancerCare Manitoba, Winnipeg, Manitoba, Canada
Dr. H. Bliss Murphy Cancer Centre, St. John's, Newfoundland and Labrador, Canada
Kingston Health Sciences Centre, Kingston, Ontario, Canada
North York General Hospital, Toronto, Ontario, Canada
Women's College Hospital, Toronto, Ontario, Canada
CIUSSS de l'Est-de-I'lle-de-Montreal, Montreal, Quebec, Canada
CHUM-Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada
Hotel-Dieu de Quebec, Quebec City, Quebec, Canada
CIUSSS de l'Estrie - Centre hospitalier, Sherbrooke, Quebec, Canada
Contact Details
Name: Amit Oza
Affiliation: Univ. Health Network-OCI/Princess Margaret Hospital, Toronto, ON Canada
Role: STUDY_CHAIR
Name: Stephanie Lheureux
Affiliation: Univ. Health Network-OCI/Princess Margaret Hospital, Toronto, ON Canada
Role: STUDY_CHAIR
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