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Spots Global Cancer Trial Database for Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)

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Trial Identification

Brief Title: Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)

Official Title: A Randomized Phase 3, Double-Blind Study of Chemotherapy With or Without Pembrolizumab Followed by Maintenance With Olaparib or Placebo for the First-Line Treatment of BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (KEYLYNK-001 / ENGOT-ov43 / GOG-3036)

Study ID: NCT03740165

Study Description

Brief Summary: The purpose of this study is to assess the efficacy and safety of treatment with carboplatin/paclitaxel\* PLUS pembrolizumab (MK-3475) and maintenance olaparib (MK-7339) in women with epithelial ovarian cancer (EOC), fallopian tube cancer, or primary peritoneal cancer. The primary study hypotheses are that the combination of pembrolizumab plus carboplatin/paclitaxel\* followed by continued pembrolizumab and maintenance olaparib is superior to carboplatin/paclitaxel alone with respect to Progression Free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) in participants with programmed death-ligand 1 (PD-L1)-positive tumors (Combined Positive Score \[CPS\]≥10) and in all participants, and that the combination of pembrolizumab plus carboplatin/paclitaxel followed by continued pembrolizumab is superior to carboplatin/paclitaxel alone with respect to PFS per RECIST 1.1 in participants with PD-L1-positive tumors (CPS≥10) and in all participants.

Detailed Description: Following a lead-in period during which all participants receive a single 3-week cycle of carboplatin/paclitaxel\*, participants will be randomly assigned in to one of three treatment arms: * Pembrolizumab + Olaparib, * Pembrolizumab + Placebo for Olaparib * Placebo for Pembrolizumab + Placebo for Olaparib * At Investigator's discretion and prior to participant randomization, one of the following carboplatin/paclitaxel regimens is to be selected: 1. up to 5 cycles of carboplatin Area Under the Curve (AUC)5 or AUC6 AND paclitaxel 175 mg/m\^2 on Day 1 of each 3-week cycle 2. up to 5 cycles of carboplatin AUC5 or AUC6 on Day 1 of each 3-week cycle AND paclitaxel 80 mg/m\^2 on Days 1, 8 and 15 of each 3-week cycle; or 3. up to 5 cycles of carboplatin AUC2 or AUC2.7 AND paclitaxel 60 mg/m\^2 on Days 1, 8 and 15 of each 3-week cycle. Docetaxel may be considered for participants who experience either a severe hypersensitivity reaction to paclitaxel or an AE requiring discontinuation of paclitaxel only after consultation with the Sponsor. The recommended dose as determined by the Scottish Gynaecological Cancer Trials Group is Docetaxel 75 mg/m\^2 Q3W plus carboplatin AUC 5 Q3W.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

University of Alabama at Birmingham (UAB) ( Site 0036), Birmingham, Alabama, United States

University of Arizona Cancer Center ( Site 0074), Tucson, Arizona, United States

Disney Family Cancer Center ( Site 0042), Burbank, California, United States

Kaiser Permanente Oncology Clinical Trial -Oakland ( Site 0077), Oakland, California, United States

Kaiser Permanente Oncology Clinical Trials-Roseville ( Site 0084), Roseville, California, United States

Kaiser Permanente Oncology Clinical Trials-Sacramento ( Site 0083), Sacramento, California, United States

Kaiser Permanente Oncology Clinical Trial - San Francisco ( Site 0078), San Francisco, California, United States

Kaiser Permanente Oncology Clinical Trial - Santa Clara ( Site 0079), Santa Clara, California, United States

Kaiser Permanente N. CA Regional Oncology Clinical Trials ( Site 0008), Vallejo, California, United States

Kaiser Permanente Oncology Clinical Trial - Walnut Creek ( Site 0080), Walnut Creek, California, United States

Smilow Cancer Center at Yale-New Haven ( Site 0057), New Haven, Connecticut, United States

Sarasota Memorial Hospital ( Site 0023), Sarasota, Florida, United States

Emory School of Medicine ( Site 0053), Atlanta, Georgia, United States

Northeast Georgia Medical Center ( Site 0029), Gainesville, Georgia, United States

Memorial Health University Medical Center ( Site 0011), Savannah, Georgia, United States

Rush University Medical Center ( Site 0019), Chicago, Illinois, United States

University of Chicago ( Site 0049), Chicago, Illinois, United States

Dr. Sudarshan K. Sharma, LTD ( Site 0061), Hinsdale, Illinois, United States

Saint Vincent Hospital and Health Center ( Site 0012), Indianapolis, Indiana, United States

University of Iowa Hospital and Clinics ( Site 0005), Iowa City, Iowa, United States

University of Kentucky ( Site 0045), Lexington, Kentucky, United States

Weinberg Cancer Institute at Franklin Square ( Site 0035), Baltimore, Maryland, United States

Saint Dominic - Jackson Memorial Hospital ( Site 0072), Jackson, Mississippi, United States

Washington University - School of Medicine ( Site 0062), Saint Louis, Missouri, United States

Nebraska Methodist Hospital ( Site 0063), Omaha, Nebraska, United States

Dartmouth Hitchcock Medical Center ( Site 0024), Lebanon, New Hampshire, United States

MD Anderson Cancer Center at Cooper ( Site 0067), Camden, New Jersey, United States

Holy Name Medical Center ( Site 0037), Teaneck, New Jersey, United States

Northwell Health- Monter Cancer Center ( Site 0075), Lake Success, New York, United States

Sanford Roger Maris Cancer Center ( Site 0082), Fargo, North Dakota, United States

Miami Valley Hospital [Dayton, OH] ( Site 0073), Centerville, Ohio, United States

Oncology/Hematology Care Clinical Trials, LLC ( Site 8001), Cincinnati, Ohio, United States

The Bing Cancer Center ( Site 0044), Columbus, Ohio, United States

OSU Wexner Medical Center ( Site 0076), Hilliard, Ohio, United States

Women and Infants Hospital [Providence, RI] ( Site 0039), Providence, Rhode Island, United States

Sanford Gynecology Oncology ( Site 0004), Sioux Falls, South Dakota, United States

Texas Oncology, P.A. - Bedford ( Site 8005), Bedford, Texas, United States

Texas Oncology-Dallas Presbyterian Hospital ( Site 8004), Dallas, Texas, United States

Parkland Hospital ( Site 0081), Dallas, Texas, United States

UT Southwestern Medical Center ( Site 0046), Dallas, Texas, United States

Texas Oncology, P.A. Texas Oncology-Tyler ( Site 8006), Tyler, Texas, United States

Virginia Cancer Specialists, PC ( Site 8003), Gainesville, Virginia, United States

MEDICAL COLLEGE OF WISCONSIN ( Site 0064), Milwaukee, Wisconsin, United States

St George Hospital ( Site 2207), Kogarah, New South Wales, Australia

Cairns and Hinterland Hospital and Health Service ( Site 2201), Cairns, Queensland, Australia

Ballarat Health Services ( Site 2202), Ballarat, Victoria, Australia

Monash Health ( Site 2204), Clayton, Victoria, Australia

Sunshine Hospital. ( Site 2205), St Albans, Victoria, Australia

Imelda Ziekenhuis Bonheiden ( Site 0301), Bonheiden, Antwerpen, Belgium

UZ Leuven Campus Gasthuisberg ( Site 0306), Leuven, Antwerpen, Belgium

Cliniques Universitaires Saint-Luc ( Site 0312), Brussels, Bruxelles-Capitale, Region De, Belgium

Grand Hopital de Charleroi ( Site 0302), Charleroi, Hainaut, Belgium

CHU de Liege ( Site 0310), Liège, Liege, Belgium

Jessa Ziekenhuis ( Site 0309), Hasselt, Limburg, Belgium

Centre Hospitalier de l'Ardenne ( Site 0303), Libramont, Luxembourg, Belgium

AZ Maria Middelares Gent ( Site 0300), Gent, Oost-Vlaanderen, Belgium

UZ Gent ( Site 0307), Gent, Oost-Vlaanderen, Belgium

Instituto do Cancer do Ceara ( Site 2707), Fortaleza, Ceara, Brazil

Hospital Araujo Jorge Associacao de Combate ao Cancer de Goias ( Site 2708), Goiania, Goias, Brazil

Hospital Erasto Gaertner ( Site 2716), Curitiba, Parana, Brazil

Hospital de Caridade de Ijui ( Site 2712), Ijui, Rio Grande Do Sul, Brazil

Hospital Bruno Born ( Site 2704), Lajeado, Rio Grande Do Sul, Brazil

Hospital Nossa Senhora Da Conceicao ( Site 2703), Porto Alegre, Rio Grande Do Sul, Brazil

Instituto Nacional de Cancer Hospital do Cancer II ( Site 2700), Rio de Janeiro, , Brazil

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 2714), Sao Paulo, , Brazil

Clinica de Pesquisas e Ctro de Estudos Onc. Ginecol. e Mamaria Ltda ( Site 2706), Sao Paulo, , Brazil

Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 2710), Sao Paulo, , Brazil

Tom Baker Cancer Centre ( Site 0200), Calgary, Alberta, Canada

Kingston Health Sciences Centre ( Site 0207), Kingston, Ontario, Canada

The Credit Valley Hospital ( Site 0206), Mississauga, Ontario, Canada

Princess Margaret Hospital.. ( Site 0202), Toronto, Ontario, Canada

CIUSSS du Saguenay-Lac-St-Jean ( Site 0218), Chicoutimi, Quebec, Canada

CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0219), Montreal, Quebec, Canada

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0208), Montreal, Quebec, Canada

Royal Victoria Hospital McGill University Health Centre ( Site 0211), Montreal, Quebec, Canada

Centro Investigación del Cáncer James Lind ( Site 2810), Temuco, Araucania, Chile

Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 2808), Temuco, Araucania, Chile

Fundacion Arturo Lopez Perez FALP ( Site 2800), Santiago, Region M. De Santiago, Chile

Sociedad Oncovida S.A. ( Site 2807), Santiago, Region M. De Santiago, Chile

Iram Cancer Research ( Site 2809), Santiago, Region M. De Santiago, Chile

Pontificia Universidad Catolica de Chile ( Site 2805), Santiago, Region M. De Santiago, Chile

Oncocentro ( Site 2801), Vina del Mar, Valparaiso, Chile

Centro Oncologico Antofagasta ( Site 2804), Antofagasta, , Chile

Biomelab S A S ( Site 2900), Barranquilla, Atlantico, Colombia

Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 2913), Valledupar, Cesar, Colombia

Oncomedica S.A. ( Site 2911), Monteria, Cordoba, Colombia

Instituto Nacional de Cancerologia E.S.E ( Site 2910), Bogota, Distrito Capital De Bogota, Colombia

Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 2912), Bogota, Distrito Capital De Bogota, Colombia

Centro Medico Imbanaco de Cali S.A ( Site 2909), Cali, Valle Del Cauca, Colombia

Hemato Oncologos S.A. ( Site 2906), Cali, Valle Del Cauca, Colombia

Fakultni nemocnice Brno ( Site 0404), Brno, Brno-mesto, Czechia

Fakultni nemocnice Ostrava ( Site 0403), Ostrava-Poruba, Moravskoslezsky Kraj, Czechia

Vseobecna fakultni nemocnice v Praze ( Site 0400), Praha, Praha, Hlavni Mesto, Czechia

Nemocnice Na Bulovce ( Site 0401), Praha, Praha, Hlavni Mesto, Czechia

Fakultni nemocnice Olomouc ( Site 0402), Olomouc, , Czechia

Hopital Prive Jean Mermoz ( Site 0607), Lyon, Auvergne, France

Centre Paul Strauss ( Site 0615), Strasbourg, Bas-Rhin, France

Hopital de la Timone ( Site 0617), Marseille, Bouches-du-Rhone, France

CHU de Brest -Site Hopital Morvan ( Site 0616), Brest, Bretagne, France

Institut de Cancerologie du Gard - CHU Caremeau ( Site 0610), Nimes, Gard, France

Institut de Cancerologie Lucien Neuwirth ( Site 0613), Saint-Priest-en-Jarez, Loire, France

Centre D Oncologie de Gentilly ( Site 0609), Nancy, Meurthe-et-Moselle, France

Institut Gustave Roussy ( Site 0600), Villejuif, Val-de-Marne, France

Hopital Tenon ( Site 0612), Paris, , France

Marienhospital Stuttgart Vincenz von Paul Kliniken gGmbH ( Site 0707), Stuttgart, Baden-Wurttemberg, Germany

Klinikum Rechts der Isar. Technischen Universitaet Muenchen ( Site 0710), Muenchen, Bayern, Germany

Uniklinik RWTH Aachen ( Site 0718), Aachen, Nordrhein-Westfalen, Germany

Gynaekologisches Zentrum ( Site 0712), Bonn, Nordrhein-Westfalen, Germany

Klinikum Dortmund gGmbH ( Site 0717), Dortmund, Nordrhein-Westfalen, Germany

Universitaetsklinikum Duesseldorf ( Site 0704), Duesseldorf, Nordrhein-Westfalen, Germany

HELIOS Klinikum Krefeld ( Site 0715), Krefeld, Nordrhein-Westfalen, Germany

Universitaetsklinikum Muenster ( Site 0720), Muenster, Nordrhein-Westfalen, Germany

Caritas Klinikum Saarbruecken St. Theresia ( Site 0702), Saarbruecken, Saarland, Germany

Klinikum Chemnitz gGmbH ( Site 0711), Chemnitz, Sachsen, Germany

Staedtisches Krankenhaus Kiel GmbH ( Site 0709), Kiel, Schleswig-Holstein, Germany

Charite Campus Virchow-Klinikum - CVK ( Site 0700), Berlin, , Germany

Pecsi Tudomanyegyetem Klinikai Kozpont ( Site 0805), Pecs, Baranya, Hungary

Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz ( Site 0802), Miskolc, Borsod-Abauj-Zemplen, Hungary

Orszagos Onkologiai Intezet ( Site 0800), Budapest, , Hungary

Uzsoki Utcai Korhaz ( Site 0803), Budapest, , Hungary

Debreceni Egyetem Klinikai Kozpont ( Site 0801), Debrecen, , Hungary

Soroka Medical Center ( Site 1006), Beer-Sheva, , Israel

Hillel Yaffe Medical Center ( Site 1011), Hadera, , Israel

Carmel Medical Center ( Site 1007), Haifa, , Israel

Rambam Medical Center ( Site 1002), Haifa, , Israel

Edith Wolfson Medical Center ( Site 1003), Holon, , Israel

Shaare Zedek Medical Center ( Site 1005), Jerusalem, , Israel

Rabin Medical Center ( Site 1004), Petah Tikva, , Israel

Chaim Sheba Medical Center ( Site 1000), Ramat Gan, , Israel

Sourasky Medical Center ( Site 1001), Tel Aviv, , Israel

IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1108), Bari, Abruzzo, Italy

Istituto Europeo di Oncologia ( Site 1100), Milano, Lombardia, Italy

A.O.U. Citta della Salute e della Scienza di Torino ( Site 1104), Torino, Piemonte, Italy

Istituto Oncologico Veneto IRCCS ( Site 1113), Padova, Veneto, Italy

Sacro Cuore di Gesu Fatebenefratelli ( Site 1112), Benevento, , Italy

Ospedale Cannizzaro ( Site 1110), Catania, , Italy

ASST Lecco. Ospedale A. Manzoni ( Site 1101), Lecco, , Italy

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1115), Milano, , Italy

A.O.U. Federico II di Napoli ( Site 1107), Napoli, , Italy

Azienda Ospedaliera Policlinico Umberto I ( Site 1111), Roma, , Italy

Policlinico Universitario Gemelli ( Site 1105), Roma, , Italy

Presidio Ospedaliero Santa Chiara ( Site 1109), Trento, , Italy

A.O. Univ. S. M. della Misericordia ( Site 1114), Udine, , Italy

National Cancer Center Hospital East ( Site 2602), Kashiwa, Chiba, Japan

National Hospital Organization Shikoku Cancer Center ( Site 2601), Matsuyama, Ehime, Japan

Ehime University Hospital ( Site 2600), Toon, Ehime, Japan

Gunma Prefectural Cancer Center ( Site 2609), Ota, Gunma, Japan

Hokkaido University Hospital ( Site 2607), Sapporo, Hokkaido, Japan

Iwate Medical University Hospital ( Site 2606), Shiwa-gun, Iwate, Japan

St. Marianna University School of Medicine Hospital ( Site 2613), Kawasaki, Kanagawa, Japan

University of the Ryukyus Hospital ( Site 2616), Nakagami-gun, Okinawa, Japan

Saitama Medical University International Medical Center ( Site 2604), Hidaka, Saitama, Japan

Saitama Cancer Center ( Site 2614), Kitaadachi-gun, Saitama, Japan

National Defense Medical College Hospital ( Site 2608), Tokorozawa, Saitama, Japan

Kyorin University Hospital ( Site 2610), Mitaka, Tokyo, Japan

Kagoshima City Hospital ( Site 2612), Kagoshima, , Japan

Niigata Cancer Center Hospital ( Site 2618), Niigata, , Japan

Osaka International Cancer Institute ( Site 2617), Osaka, , Japan

National Cancer Center Hospital ( Site 2605), Tokyo, , Japan

Seoul National University Bundang Hospital ( Site 2404), Seongnam-si, Kyonggi-do, Korea, Republic of

Seoul National University Hospital ( Site 2403), Seoul, , Korea, Republic of

Severance Hospital Yonsei University Health System ( Site 2400), Seoul, , Korea, Republic of

Asan Medical Center ( Site 2402), Seoul, , Korea, Republic of

Samsung Medical Center ( Site 2401), Seoul, , Korea, Republic of

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warszawa, Mazowieckie, Poland

Bialostockie Centrum Onkologii ( Site 1412), Bialystok, Podlaskie, Poland

Szpitale Pomorskie Sp. z o.o. ( Site 1407), Gdynia, Pomorskie, Poland

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1406), Gliwice, Slaskie, Poland

Swietokrzyskie Centrum Onkologii SPZOZ ( Site 1410), Kielce, Swietokrzyskie, Poland

Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu Medycznego im. K. Marcinkowskiego w Pozna, Poznan, Wielkopolskie, Poland

Arkhangelsk Clinical Oncological Dispensary ( Site 1508), Arkhangelsk, Arkhangel Skaya Oblast, Russian Federation

Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1507), Ufa, Baskortostan, Respublika, Russian Federation

A. Tsyb Medical Radiological Research Center ( Site 1513), Obninsk, Kaluzskaja Oblast, Russian Federation

FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 1500), Moscow, Moskva, Russian Federation

FSCC of Special Types of Med. Care and Technologies ( Site 1503), Moscow, Moskva, Russian Federation

Medical Rehabilitation Center ( Site 1502), Moscow, Moskva, Russian Federation

City Clinical Oncology Center ( Site 1505), Saint Petersburg, Sankt-Peterburg, Russian Federation

National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 1504), Saint-Petersburg, Sankt-Peterburg, Russian Federation

Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1509), Kazan, Tatarstan, Respublika, Russian Federation

Cancer Care Langenhoven Drive Oncology Centre ( Site 1701), Port Elizabeth, Eastern Cape, South Africa

Groote Schuur Hospital ( Site 1704), Cape Town, Gauteng, South Africa

Wits Clinical Research ( Site 1702), Johannesburg, Gauteng, South Africa

Department of Medical Oncology ( Site 1703), Pretoria, Gauteng, South Africa

Curo Oncology ( Site 1710), Pretoria, Gauteng, South Africa

Wilgers Oncology Centre ( Site 1705), Pretoria, Gauteng, South Africa

Little Company of Mary Hospital ( Site 1700), Pretoria, Gauteng, South Africa

Sandton Oncology Medical Group PTY LTD ( Site 1712), Sandton, Gauteng, South Africa

The Oncology Centre ( Site 1709), Durban, Kwazulu-Natal, South Africa

Cancercare ( Site 1706), Cape Town, Western Cape, South Africa

Outeniqua Cancercare Oncology Unit ( Site 1708), George, Western Cape, South Africa

Cape Town Oncology Trials Pty Ltd ( Site 1707), Kraaifontein, Western Cape, South Africa

Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 1603), Hospitalet de Llobregat, Barcelona, Spain

Xarxa Assistencial Universitaria Manresa ( Site 1605), Manresa, Barcelona, Spain

Hospital de Terrassa ( Site 1606), Terrassa, Barcelona, Spain

Hospital Universitario de Donostia ( Site 1602), Donostia, Gipuzkoa, Spain

Complejo Hospitalario Universitario A Coruna. CHUAC ( Site 1608), A Coruna, La Coruna, Spain

Instituto Valenciano de Oncologia ( Site 1601), Valencia, Valenciana, Comunitat, Spain

Hospital General Universitario de Valencia ( Site 1610), Valencia, Valenciana, Comunitat, Spain

Hospital Provincial San Pedro de Alcantara ( Site 1607), Caceres, , Spain

Hospital Universitario Lucus Augusti ( Site 1609), Lugo, , Spain

Clinica Universitaria de Navarra ( Site 1600), Madrid, , Spain

Hospital Universitario Virgen del Rocio ( Site 1604), Sevilla, , Spain

Changhua Christian Hospital ( Site 2507), Changhua, , Taiwan

China Medical University Hospital ( Site 2506), Taichung, , Taiwan

Taichung Veterans General Hospital ( Site 2510), Taichung, , Taiwan

National Cheng Kung University Hospital ( Site 2508), Tainan, , Taiwan

National Taiwan University Hospital ( Site 2502), Taipei, , Taiwan

MacKay Memorial Hospital ( Site 2500), Taipei, , Taiwan

Taipei Veterans General Hospital ( Site 2503), Taipei, , Taiwan

Linkou Chang Gung Memorial Hospital ( Site 2501), Taoyuan, , Taiwan

Istanbul Acibadem University Atakent Hospital ( Site 1902), Kucukcekmece, Istanbul, Turkey

Etlik Zubeyde Hanim Kadin Hastaliklari Egitim ve Arastirma Hastanesi ( Site 1903), Ankara, , Turkey

Ankara UTF Cebeci Arastırma ve Uygulama Hastanesi ( Site 1905), Ankara, , Turkey

Akdeniz Universitesi Tıp Fakultesi ( Site 1901), Antalya, , Turkey

Uludag Universitesi Tip Fakultesi ( Site 1904), Bursa, , Turkey

Istanbul Universitesi Istanbul Tip Fakultesi ( Site 1900), Istanbul, , Turkey

Bakirkoy Sadi Konuk Egitim ve Arastirma Hastanesi ( Site 1907), Istanbul, , Turkey

Medipol Universite Hastanesi ( Site 1909), Istanbul, , Turkey

Sakarya Universitesi Tip Fakultesi Hastanesi ( Site 1906), Sakarya, , Turkey

MI Precarpathian Clinical Oncology Center ( Site 2181), Ivano-Frankivsk, Ivano-Frankivska Oblast, Ukraine

Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2180), Kharkiv, Kharkivska Oblast, Ukraine

Municipal non-profit Enterprise Khmelnytskyi Regional Antitu-Gynecological Oncology department, Poli, Khmelnytskyi, Khmelnytska Oblast, Ukraine

Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 2170), Lviv, Lvivska Oblast, Ukraine

MI Odessa Regional Oncological Centre ( Site 2121), Odesa, Odeska Oblast, Ukraine

RMI - Sumy Regional Clinical Oncology Dispensary ( Site 2191), Sumy, Sumska Oblast, Ukraine

Central City Clinical Hospital ( Site 2150), Uzhgorod, Zakarpatska Oblast, Ukraine

Kyiv City Clinical Oncological Center ( Site 2140), Kyiv, , Ukraine

Contact Details

Name: Medical Director

Affiliation: Merck Sharp & Dohme LLC

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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