Spots Global Cancer Trial Database for Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)
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Trial Identification
Brief Title: Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)
Official Title: A Randomized Phase 3, Double-Blind Study of Chemotherapy With or Without Pembrolizumab Followed by Maintenance With Olaparib or Placebo for the First-Line Treatment of BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (KEYLYNK-001 / ENGOT-ov43 / GOG-3036)
Study ID: NCT03740165
Study Description
Brief Summary: The purpose of this study is to assess the efficacy and safety of treatment with carboplatin/paclitaxel\* PLUS pembrolizumab (MK-3475) and maintenance olaparib (MK-7339) in women with epithelial ovarian cancer (EOC), fallopian tube cancer, or primary peritoneal cancer. The primary study hypotheses are that the combination of pembrolizumab plus carboplatin/paclitaxel\* followed by continued pembrolizumab and maintenance olaparib is superior to carboplatin/paclitaxel alone with respect to Progression Free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) in participants with programmed death-ligand 1 (PD-L1)-positive tumors (Combined Positive Score \[CPS\]≥10) and in all participants, and that the combination of pembrolizumab plus carboplatin/paclitaxel followed by continued pembrolizumab is superior to carboplatin/paclitaxel alone with respect to PFS per RECIST 1.1 in participants with PD-L1-positive tumors (CPS≥10) and in all participants.
Detailed Description: Following a lead-in period during which all participants receive a single 3-week cycle of carboplatin/paclitaxel\*, participants will be randomly assigned in to one of three treatment arms: * Pembrolizumab + Olaparib, * Pembrolizumab + Placebo for Olaparib * Placebo for Pembrolizumab + Placebo for Olaparib * At Investigator's discretion and prior to participant randomization, one of the following carboplatin/paclitaxel regimens is to be selected: 1. up to 5 cycles of carboplatin Area Under the Curve (AUC)5 or AUC6 AND paclitaxel 175 mg/m\^2 on Day 1 of each 3-week cycle 2. up to 5 cycles of carboplatin AUC5 or AUC6 on Day 1 of each 3-week cycle AND paclitaxel 80 mg/m\^2 on Days 1, 8 and 15 of each 3-week cycle; or 3. up to 5 cycles of carboplatin AUC2 or AUC2.7 AND paclitaxel 60 mg/m\^2 on Days 1, 8 and 15 of each 3-week cycle. Docetaxel may be considered for participants who experience either a severe hypersensitivity reaction to paclitaxel or an AE requiring discontinuation of paclitaxel only after consultation with the Sponsor. The recommended dose as determined by the Scottish Gynaecological Cancer Trials Group is Docetaxel 75 mg/m\^2 Q3W plus carboplatin AUC 5 Q3W.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
University of Alabama at Birmingham (UAB) ( Site 0036), Birmingham, Alabama, United States
University of Arizona Cancer Center ( Site 0074), Tucson, Arizona, United States
Disney Family Cancer Center ( Site 0042), Burbank, California, United States
Kaiser Permanente Oncology Clinical Trial -Oakland ( Site 0077), Oakland, California, United States
Kaiser Permanente Oncology Clinical Trials-Roseville ( Site 0084), Roseville, California, United States
Kaiser Permanente Oncology Clinical Trials-Sacramento ( Site 0083), Sacramento, California, United States
Kaiser Permanente Oncology Clinical Trial - San Francisco ( Site 0078), San Francisco, California, United States
Kaiser Permanente Oncology Clinical Trial - Santa Clara ( Site 0079), Santa Clara, California, United States
Kaiser Permanente N. CA Regional Oncology Clinical Trials ( Site 0008), Vallejo, California, United States
Kaiser Permanente Oncology Clinical Trial - Walnut Creek ( Site 0080), Walnut Creek, California, United States
Smilow Cancer Center at Yale-New Haven ( Site 0057), New Haven, Connecticut, United States
Sarasota Memorial Hospital ( Site 0023), Sarasota, Florida, United States
Emory School of Medicine ( Site 0053), Atlanta, Georgia, United States
Northeast Georgia Medical Center ( Site 0029), Gainesville, Georgia, United States
Memorial Health University Medical Center ( Site 0011), Savannah, Georgia, United States
Rush University Medical Center ( Site 0019), Chicago, Illinois, United States
University of Chicago ( Site 0049), Chicago, Illinois, United States
Dr. Sudarshan K. Sharma, LTD ( Site 0061), Hinsdale, Illinois, United States
Saint Vincent Hospital and Health Center ( Site 0012), Indianapolis, Indiana, United States
University of Iowa Hospital and Clinics ( Site 0005), Iowa City, Iowa, United States
University of Kentucky ( Site 0045), Lexington, Kentucky, United States
Weinberg Cancer Institute at Franklin Square ( Site 0035), Baltimore, Maryland, United States
Saint Dominic - Jackson Memorial Hospital ( Site 0072), Jackson, Mississippi, United States
Washington University - School of Medicine ( Site 0062), Saint Louis, Missouri, United States
Nebraska Methodist Hospital ( Site 0063), Omaha, Nebraska, United States
Dartmouth Hitchcock Medical Center ( Site 0024), Lebanon, New Hampshire, United States
MD Anderson Cancer Center at Cooper ( Site 0067), Camden, New Jersey, United States
Holy Name Medical Center ( Site 0037), Teaneck, New Jersey, United States
Northwell Health- Monter Cancer Center ( Site 0075), Lake Success, New York, United States
Sanford Roger Maris Cancer Center ( Site 0082), Fargo, North Dakota, United States
Miami Valley Hospital [Dayton, OH] ( Site 0073), Centerville, Ohio, United States
Oncology/Hematology Care Clinical Trials, LLC ( Site 8001), Cincinnati, Ohio, United States
The Bing Cancer Center ( Site 0044), Columbus, Ohio, United States
OSU Wexner Medical Center ( Site 0076), Hilliard, Ohio, United States
Women and Infants Hospital [Providence, RI] ( Site 0039), Providence, Rhode Island, United States
Sanford Gynecology Oncology ( Site 0004), Sioux Falls, South Dakota, United States
Texas Oncology, P.A. - Bedford ( Site 8005), Bedford, Texas, United States
Texas Oncology-Dallas Presbyterian Hospital ( Site 8004), Dallas, Texas, United States
Parkland Hospital ( Site 0081), Dallas, Texas, United States
UT Southwestern Medical Center ( Site 0046), Dallas, Texas, United States
Texas Oncology, P.A. Texas Oncology-Tyler ( Site 8006), Tyler, Texas, United States
Virginia Cancer Specialists, PC ( Site 8003), Gainesville, Virginia, United States
MEDICAL COLLEGE OF WISCONSIN ( Site 0064), Milwaukee, Wisconsin, United States
St George Hospital ( Site 2207), Kogarah, New South Wales, Australia
Cairns and Hinterland Hospital and Health Service ( Site 2201), Cairns, Queensland, Australia
Ballarat Health Services ( Site 2202), Ballarat, Victoria, Australia
Monash Health ( Site 2204), Clayton, Victoria, Australia
Sunshine Hospital. ( Site 2205), St Albans, Victoria, Australia
Imelda Ziekenhuis Bonheiden ( Site 0301), Bonheiden, Antwerpen, Belgium
UZ Leuven Campus Gasthuisberg ( Site 0306), Leuven, Antwerpen, Belgium
Cliniques Universitaires Saint-Luc ( Site 0312), Brussels, Bruxelles-Capitale, Region De, Belgium
Grand Hopital de Charleroi ( Site 0302), Charleroi, Hainaut, Belgium
CHU de Liege ( Site 0310), Liège, Liege, Belgium
Jessa Ziekenhuis ( Site 0309), Hasselt, Limburg, Belgium
Centre Hospitalier de l'Ardenne ( Site 0303), Libramont, Luxembourg, Belgium
AZ Maria Middelares Gent ( Site 0300), Gent, Oost-Vlaanderen, Belgium
UZ Gent ( Site 0307), Gent, Oost-Vlaanderen, Belgium
Instituto do Cancer do Ceara ( Site 2707), Fortaleza, Ceara, Brazil
Hospital Araujo Jorge Associacao de Combate ao Cancer de Goias ( Site 2708), Goiania, Goias, Brazil
Hospital Erasto Gaertner ( Site 2716), Curitiba, Parana, Brazil
Hospital de Caridade de Ijui ( Site 2712), Ijui, Rio Grande Do Sul, Brazil
Hospital Bruno Born ( Site 2704), Lajeado, Rio Grande Do Sul, Brazil
Hospital Nossa Senhora Da Conceicao ( Site 2703), Porto Alegre, Rio Grande Do Sul, Brazil
Instituto Nacional de Cancer Hospital do Cancer II ( Site 2700), Rio de Janeiro, , Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 2714), Sao Paulo, , Brazil
Clinica de Pesquisas e Ctro de Estudos Onc. Ginecol. e Mamaria Ltda ( Site 2706), Sao Paulo, , Brazil
Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 2710), Sao Paulo, , Brazil
Tom Baker Cancer Centre ( Site 0200), Calgary, Alberta, Canada
Kingston Health Sciences Centre ( Site 0207), Kingston, Ontario, Canada
The Credit Valley Hospital ( Site 0206), Mississauga, Ontario, Canada
Princess Margaret Hospital.. ( Site 0202), Toronto, Ontario, Canada
CIUSSS du Saguenay-Lac-St-Jean ( Site 0218), Chicoutimi, Quebec, Canada
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0219), Montreal, Quebec, Canada
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0208), Montreal, Quebec, Canada
Royal Victoria Hospital McGill University Health Centre ( Site 0211), Montreal, Quebec, Canada
Centro Investigación del Cáncer James Lind ( Site 2810), Temuco, Araucania, Chile
Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 2808), Temuco, Araucania, Chile
Fundacion Arturo Lopez Perez FALP ( Site 2800), Santiago, Region M. De Santiago, Chile
Sociedad Oncovida S.A. ( Site 2807), Santiago, Region M. De Santiago, Chile
Iram Cancer Research ( Site 2809), Santiago, Region M. De Santiago, Chile
Pontificia Universidad Catolica de Chile ( Site 2805), Santiago, Region M. De Santiago, Chile
Oncocentro ( Site 2801), Vina del Mar, Valparaiso, Chile
Centro Oncologico Antofagasta ( Site 2804), Antofagasta, , Chile
Biomelab S A S ( Site 2900), Barranquilla, Atlantico, Colombia
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 2913), Valledupar, Cesar, Colombia
Oncomedica S.A. ( Site 2911), Monteria, Cordoba, Colombia
Instituto Nacional de Cancerologia E.S.E ( Site 2910), Bogota, Distrito Capital De Bogota, Colombia
Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 2912), Bogota, Distrito Capital De Bogota, Colombia
Centro Medico Imbanaco de Cali S.A ( Site 2909), Cali, Valle Del Cauca, Colombia
Hemato Oncologos S.A. ( Site 2906), Cali, Valle Del Cauca, Colombia
Fakultni nemocnice Brno ( Site 0404), Brno, Brno-mesto, Czechia
Fakultni nemocnice Ostrava ( Site 0403), Ostrava-Poruba, Moravskoslezsky Kraj, Czechia
Vseobecna fakultni nemocnice v Praze ( Site 0400), Praha, Praha, Hlavni Mesto, Czechia
Nemocnice Na Bulovce ( Site 0401), Praha, Praha, Hlavni Mesto, Czechia
Fakultni nemocnice Olomouc ( Site 0402), Olomouc, , Czechia
Hopital Prive Jean Mermoz ( Site 0607), Lyon, Auvergne, France
Centre Paul Strauss ( Site 0615), Strasbourg, Bas-Rhin, France
Hopital de la Timone ( Site 0617), Marseille, Bouches-du-Rhone, France
CHU de Brest -Site Hopital Morvan ( Site 0616), Brest, Bretagne, France
Institut de Cancerologie du Gard - CHU Caremeau ( Site 0610), Nimes, Gard, France
Institut de Cancerologie Lucien Neuwirth ( Site 0613), Saint-Priest-en-Jarez, Loire, France
Centre D Oncologie de Gentilly ( Site 0609), Nancy, Meurthe-et-Moselle, France
Institut Gustave Roussy ( Site 0600), Villejuif, Val-de-Marne, France
Hopital Tenon ( Site 0612), Paris, , France
Marienhospital Stuttgart Vincenz von Paul Kliniken gGmbH ( Site 0707), Stuttgart, Baden-Wurttemberg, Germany
Klinikum Rechts der Isar. Technischen Universitaet Muenchen ( Site 0710), Muenchen, Bayern, Germany
Uniklinik RWTH Aachen ( Site 0718), Aachen, Nordrhein-Westfalen, Germany
Gynaekologisches Zentrum ( Site 0712), Bonn, Nordrhein-Westfalen, Germany
Klinikum Dortmund gGmbH ( Site 0717), Dortmund, Nordrhein-Westfalen, Germany
Universitaetsklinikum Duesseldorf ( Site 0704), Duesseldorf, Nordrhein-Westfalen, Germany
HELIOS Klinikum Krefeld ( Site 0715), Krefeld, Nordrhein-Westfalen, Germany
Universitaetsklinikum Muenster ( Site 0720), Muenster, Nordrhein-Westfalen, Germany
Caritas Klinikum Saarbruecken St. Theresia ( Site 0702), Saarbruecken, Saarland, Germany
Klinikum Chemnitz gGmbH ( Site 0711), Chemnitz, Sachsen, Germany
Staedtisches Krankenhaus Kiel GmbH ( Site 0709), Kiel, Schleswig-Holstein, Germany
Charite Campus Virchow-Klinikum - CVK ( Site 0700), Berlin, , Germany
Pecsi Tudomanyegyetem Klinikai Kozpont ( Site 0805), Pecs, Baranya, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz ( Site 0802), Miskolc, Borsod-Abauj-Zemplen, Hungary
Orszagos Onkologiai Intezet ( Site 0800), Budapest, , Hungary
Uzsoki Utcai Korhaz ( Site 0803), Budapest, , Hungary
Debreceni Egyetem Klinikai Kozpont ( Site 0801), Debrecen, , Hungary
Soroka Medical Center ( Site 1006), Beer-Sheva, , Israel
Hillel Yaffe Medical Center ( Site 1011), Hadera, , Israel
Carmel Medical Center ( Site 1007), Haifa, , Israel
Rambam Medical Center ( Site 1002), Haifa, , Israel
Edith Wolfson Medical Center ( Site 1003), Holon, , Israel
Shaare Zedek Medical Center ( Site 1005), Jerusalem, , Israel
Rabin Medical Center ( Site 1004), Petah Tikva, , Israel
Chaim Sheba Medical Center ( Site 1000), Ramat Gan, , Israel
Sourasky Medical Center ( Site 1001), Tel Aviv, , Israel
IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1108), Bari, Abruzzo, Italy
Istituto Europeo di Oncologia ( Site 1100), Milano, Lombardia, Italy
A.O.U. Citta della Salute e della Scienza di Torino ( Site 1104), Torino, Piemonte, Italy
Istituto Oncologico Veneto IRCCS ( Site 1113), Padova, Veneto, Italy
Sacro Cuore di Gesu Fatebenefratelli ( Site 1112), Benevento, , Italy
Ospedale Cannizzaro ( Site 1110), Catania, , Italy
ASST Lecco. Ospedale A. Manzoni ( Site 1101), Lecco, , Italy
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1115), Milano, , Italy
A.O.U. Federico II di Napoli ( Site 1107), Napoli, , Italy
Azienda Ospedaliera Policlinico Umberto I ( Site 1111), Roma, , Italy
Policlinico Universitario Gemelli ( Site 1105), Roma, , Italy
Presidio Ospedaliero Santa Chiara ( Site 1109), Trento, , Italy
A.O. Univ. S. M. della Misericordia ( Site 1114), Udine, , Italy
National Cancer Center Hospital East ( Site 2602), Kashiwa, Chiba, Japan
National Hospital Organization Shikoku Cancer Center ( Site 2601), Matsuyama, Ehime, Japan
Ehime University Hospital ( Site 2600), Toon, Ehime, Japan
Gunma Prefectural Cancer Center ( Site 2609), Ota, Gunma, Japan
Hokkaido University Hospital ( Site 2607), Sapporo, Hokkaido, Japan
Iwate Medical University Hospital ( Site 2606), Shiwa-gun, Iwate, Japan
St. Marianna University School of Medicine Hospital ( Site 2613), Kawasaki, Kanagawa, Japan
University of the Ryukyus Hospital ( Site 2616), Nakagami-gun, Okinawa, Japan
Saitama Medical University International Medical Center ( Site 2604), Hidaka, Saitama, Japan
Saitama Cancer Center ( Site 2614), Kitaadachi-gun, Saitama, Japan
National Defense Medical College Hospital ( Site 2608), Tokorozawa, Saitama, Japan
Kyorin University Hospital ( Site 2610), Mitaka, Tokyo, Japan
Kagoshima City Hospital ( Site 2612), Kagoshima, , Japan
Niigata Cancer Center Hospital ( Site 2618), Niigata, , Japan
Osaka International Cancer Institute ( Site 2617), Osaka, , Japan
National Cancer Center Hospital ( Site 2605), Tokyo, , Japan
Seoul National University Bundang Hospital ( Site 2404), Seongnam-si, Kyonggi-do, Korea, Republic of
Seoul National University Hospital ( Site 2403), Seoul, , Korea, Republic of
Severance Hospital Yonsei University Health System ( Site 2400), Seoul, , Korea, Republic of
Asan Medical Center ( Site 2402), Seoul, , Korea, Republic of
Samsung Medical Center ( Site 2401), Seoul, , Korea, Republic of
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warszawa, Mazowieckie, Poland
Bialostockie Centrum Onkologii ( Site 1412), Bialystok, Podlaskie, Poland
Szpitale Pomorskie Sp. z o.o. ( Site 1407), Gdynia, Pomorskie, Poland
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1406), Gliwice, Slaskie, Poland
Swietokrzyskie Centrum Onkologii SPZOZ ( Site 1410), Kielce, Swietokrzyskie, Poland
Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu Medycznego im. K. Marcinkowskiego w Pozna, Poznan, Wielkopolskie, Poland
Arkhangelsk Clinical Oncological Dispensary ( Site 1508), Arkhangelsk, Arkhangel Skaya Oblast, Russian Federation
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1507), Ufa, Baskortostan, Respublika, Russian Federation
A. Tsyb Medical Radiological Research Center ( Site 1513), Obninsk, Kaluzskaja Oblast, Russian Federation
FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 1500), Moscow, Moskva, Russian Federation
FSCC of Special Types of Med. Care and Technologies ( Site 1503), Moscow, Moskva, Russian Federation
Medical Rehabilitation Center ( Site 1502), Moscow, Moskva, Russian Federation
City Clinical Oncology Center ( Site 1505), Saint Petersburg, Sankt-Peterburg, Russian Federation
National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 1504), Saint-Petersburg, Sankt-Peterburg, Russian Federation
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1509), Kazan, Tatarstan, Respublika, Russian Federation
Cancer Care Langenhoven Drive Oncology Centre ( Site 1701), Port Elizabeth, Eastern Cape, South Africa
Groote Schuur Hospital ( Site 1704), Cape Town, Gauteng, South Africa
Wits Clinical Research ( Site 1702), Johannesburg, Gauteng, South Africa
Department of Medical Oncology ( Site 1703), Pretoria, Gauteng, South Africa
Curo Oncology ( Site 1710), Pretoria, Gauteng, South Africa
Wilgers Oncology Centre ( Site 1705), Pretoria, Gauteng, South Africa
Little Company of Mary Hospital ( Site 1700), Pretoria, Gauteng, South Africa
Sandton Oncology Medical Group PTY LTD ( Site 1712), Sandton, Gauteng, South Africa
The Oncology Centre ( Site 1709), Durban, Kwazulu-Natal, South Africa
Cancercare ( Site 1706), Cape Town, Western Cape, South Africa
Outeniqua Cancercare Oncology Unit ( Site 1708), George, Western Cape, South Africa
Cape Town Oncology Trials Pty Ltd ( Site 1707), Kraaifontein, Western Cape, South Africa
Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 1603), Hospitalet de Llobregat, Barcelona, Spain
Xarxa Assistencial Universitaria Manresa ( Site 1605), Manresa, Barcelona, Spain
Hospital de Terrassa ( Site 1606), Terrassa, Barcelona, Spain
Hospital Universitario de Donostia ( Site 1602), Donostia, Gipuzkoa, Spain
Complejo Hospitalario Universitario A Coruna. CHUAC ( Site 1608), A Coruna, La Coruna, Spain
Instituto Valenciano de Oncologia ( Site 1601), Valencia, Valenciana, Comunitat, Spain
Hospital General Universitario de Valencia ( Site 1610), Valencia, Valenciana, Comunitat, Spain
Hospital Provincial San Pedro de Alcantara ( Site 1607), Caceres, , Spain
Hospital Universitario Lucus Augusti ( Site 1609), Lugo, , Spain
Clinica Universitaria de Navarra ( Site 1600), Madrid, , Spain
Hospital Universitario Virgen del Rocio ( Site 1604), Sevilla, , Spain
Changhua Christian Hospital ( Site 2507), Changhua, , Taiwan
China Medical University Hospital ( Site 2506), Taichung, , Taiwan
Taichung Veterans General Hospital ( Site 2510), Taichung, , Taiwan
National Cheng Kung University Hospital ( Site 2508), Tainan, , Taiwan
National Taiwan University Hospital ( Site 2502), Taipei, , Taiwan
MacKay Memorial Hospital ( Site 2500), Taipei, , Taiwan
Taipei Veterans General Hospital ( Site 2503), Taipei, , Taiwan
Linkou Chang Gung Memorial Hospital ( Site 2501), Taoyuan, , Taiwan
Istanbul Acibadem University Atakent Hospital ( Site 1902), Kucukcekmece, Istanbul, Turkey
Etlik Zubeyde Hanim Kadin Hastaliklari Egitim ve Arastirma Hastanesi ( Site 1903), Ankara, , Turkey
Ankara UTF Cebeci Arastırma ve Uygulama Hastanesi ( Site 1905), Ankara, , Turkey
Akdeniz Universitesi Tıp Fakultesi ( Site 1901), Antalya, , Turkey
Uludag Universitesi Tip Fakultesi ( Site 1904), Bursa, , Turkey
Istanbul Universitesi Istanbul Tip Fakultesi ( Site 1900), Istanbul, , Turkey
Bakirkoy Sadi Konuk Egitim ve Arastirma Hastanesi ( Site 1907), Istanbul, , Turkey
Medipol Universite Hastanesi ( Site 1909), Istanbul, , Turkey
Sakarya Universitesi Tip Fakultesi Hastanesi ( Site 1906), Sakarya, , Turkey
MI Precarpathian Clinical Oncology Center ( Site 2181), Ivano-Frankivsk, Ivano-Frankivska Oblast, Ukraine
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2180), Kharkiv, Kharkivska Oblast, Ukraine
Municipal non-profit Enterprise Khmelnytskyi Regional Antitu-Gynecological Oncology department, Poli, Khmelnytskyi, Khmelnytska Oblast, Ukraine
Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 2170), Lviv, Lvivska Oblast, Ukraine
MI Odessa Regional Oncological Centre ( Site 2121), Odesa, Odeska Oblast, Ukraine
RMI - Sumy Regional Clinical Oncology Dispensary ( Site 2191), Sumy, Sumska Oblast, Ukraine
Central City Clinical Hospital ( Site 2150), Uzhgorod, Zakarpatska Oblast, Ukraine
Kyiv City Clinical Oncological Center ( Site 2140), Kyiv, , Ukraine
Contact Details
Name: Medical Director
Affiliation: Merck Sharp & Dohme LLC
Role: STUDY_DIRECTOR
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