Spots Global Cancer Trial Database for A Study of ZN-c3 and Niraparib in Subjects With Platinum-Resistant Ovarian Cancer
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Trial Identification
Brief Title: A Study of ZN-c3 and Niraparib in Subjects With Platinum-Resistant Ovarian Cancer
Official Title: A Phase 1/2 Dose-Escalation and Dose-Expansion Study of ZN-c3 in Combination With Niraparib in Subjects With Platinum-Resistant Ovarian Cancer
Study ID: NCT05198804
Study Description
Brief Summary: This is a Phase 1/2 study to evaluate the safety, clinical activity, pharmacokinetics (PK), and pharmacodynamics (PD) of ZN-c3 in combination with niraparib in subjects with platinum-resistant ovarian cancer.
Detailed Description: This is a Phase 1/2 open-label, multicenter study to evaluate the safety, clinical activity, PK, and PD of ZN-c3 in combination with niraparib in subjects with platinum-resistant ovarian cancer who have failed Poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance treatment.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Arizona Oncology Associates (Wilmot HOPE) - USOR, Tucson, Arizona, United States
Rocky Mountain Cancer Centers, Aurora, Colorado, United States
University of Colorado, Aurora, Colorado, United States
Karmanos Cancer Institute, Detroit, Michigan, United States
Spectrum Health System, Grand Rapids, Michigan, United States
Rutgers New Jersey Medical School, Newark, New Jersey, United States
Optimum Clinical Research Group- Women's Oncology, Albuquerque, New Mexico, United States
The Blavatnik Family - Chelsea Medical Center at Mount Sinai, New York, New York, United States
Willamette Valley Cancer Institute and Research Center, Eugene, Oregon, United States
Women and Infants Hospital of Rhode Island, Providence, Rhode Island, United States
Texas Oncology-Fort Worth Cancer Center, Fort Worth, Texas, United States
University of Virginia, Charlottesville, Virginia, United States
Virginia Cancer Specialists, Fairfax, Virginia, United States
Centre Georges François Leclerc, Dijon, , France
Centre Oscar Lambret, Lille, , France
Centre Hospitalier Lyon Sud, Saint-Genis-Laval, , France
ICANS - Institut de cancérologie Strasbourg Europe, Strasbourg, , France
EDOG - Institut Claudius Regaud, Toulouse, , France
Institut Gustave Roussy, Villejuif, , France
Contact Details
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