Spots Global Cancer Trial Database for Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
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Trial Identification
Brief Title: Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
Official Title: A Modular Phase I/IIa, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
Study ID: NCT04644068
Study Description
Brief Summary: This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.
Detailed Description: This study is a Phase I/IIa modular, open-label, multi-center study of AZD5305 administered orally, either as monotherapy or in combination with other anti-cancer agents in patients with advanced solid malignancies.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, San Francisco, California, United States
Research Site, Boston, Massachusetts, United States
Research Site, Boston, Massachusetts, United States
Research Site, New York, New York, United States
Research Site, Oklahoma City, Oklahoma, United States
Research Site, Houston, Texas, United States
Research Site, Heidelberg, , Australia
Research Site, Melbourne, , Australia
Research Site, Kelowna, British Columbia, Canada
Research Site, Vancouver, British Columbia, Canada
Research Site, London, Ontario, Canada
Research Site, Ottawa, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Quebec, , Canada
Research Site, Beijing, , China
Research Site, Changchun, , China
Research Site, Changsha, , China
Research Site, Changsha, , China
Research Site, Chengdu, , China
Research Site, Chongqing, , China
Research Site, Guangzhou, , China
Research Site, Harbin, , China
Research Site, Jining, , China
Research Site, Shandong, , China
Research Site, Shanghai, , China
Research Site, Shanghai, , China
Research Site, Taiyuan, , China
Research Site, Wuhan, , China
Research Site, Wuhan, , China
Research Site, Xi'an, , China
Research Site, Brno, , Czechia
Research Site, Olomouc, , Czechia
Research Site, Praha, , Czechia
Research Site, Budapest, , Hungary
Research Site, Budapest, , Hungary
Research Site, Budapest, , Hungary
Research Site, Milano, , Italy
Research Site, Milan, , Italy
Research Site, Modena, , Italy
Research Site, Napoli, , Italy
Research Site, Padova, , Italy
Research Site, Roma, , Italy
Research Site, Chuo-ku, , Japan
Research Site, Koto-ku, , Japan
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Bydgoszcz, , Poland
Research Site, Gdańsk, , Poland
Research Site, Gdynia, , Poland
Research Site, Gliwice, , Poland
Research Site, Grzepnica, , Poland
Research Site, Kraków, , Poland
Research Site, Lublin, , Poland
Research Site, Toruń, , Poland
Research Site, Warszawa, , Poland
Research Site, Łódź, , Poland
Research Site, Moscow, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Barcelona, , Spain
Research Site, Madrid, , Spain
Research Site, Madrid, , Spain
Research Site, Madrid, , Spain
Research Site, Málaga, , Spain
Research Site, Pozuelo de Alarcon, , Spain
Research Site, Sevilla, , Spain
Research Site, Cambridge, , United Kingdom
Research Site, Manchester, , United Kingdom
Research Site, Oxford, , United Kingdom
Research Site, Sutton, , United Kingdom
Contact Details
Name: Timothy Yap
Affiliation: M.D. Anderson Cancer Center
Role: PRINCIPAL_INVESTIGATOR
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