Spots Global Cancer Trial Database for Radiolabeled Folic Acid and Imaging to Detect Ovarian Cancer

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Trial Identification

Brief Title: Radiolabeled Folic Acid and Imaging to Detect Ovarian Cancer

Official Title: A Study to Determine the Ability of Folate Conjugates to Target Folate Receptors in Ovarian Cancer Tumors

Study ID: NCT00003763

Conditions

Ovarian Cancer

Interventions

radionuclide imaging

indium In 111 folic acid

Study Description

Brief Summary: RATIONALE: Diagnostic procedures using the drug radiolabeled folic acid and imaging may be effective in detecting ovarian cancer. PURPOSE: Diagnostic trial to study the effectiveness of radiolabeled folic acid plus imaging in detecting ovarian cancer.

Detailed Description: OBJECTIVES: I. Evaluate the effectiveness of folic acid conjugated with indium In 111 to diagnose ovarian cancer and locate metastatic disease. OUTLINE: This is a diagnostic study. Patients receive an injection of folic acid conjugated with indium In 111. The patient then undergoes imaging studies at various time points (e.g., 1, 4, and 24 hours). Patients then undergo exploratory surgery, the results of which are then compared to the imaging studies. PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.