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Spots Global Cancer Trial Database for Diffusion-weighted Imaging Study in Cancer of the Ovary

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Trial Identification

Brief Title: Diffusion-weighted Imaging Study in Cancer of the Ovary

Official Title: Assessing Treatment Response of Peritoneal Metastases in Ovarian Cancer Using Diffusion Weighted Magnetic Resonance Imaging.

Study ID: NCT01505829

Interventions

Study Description

Brief Summary: This project seeks to develop a quantitative imaging biomarker for evaluating and monitoring treatment response in ovarian cancer metastases and assess its potential in monitoring treatment response. This will involve standardising DW-MRI for the abdomen and pelvis across multiple centres and platforms, assessing reproducibility of the measurement in patients planned for neoadjuvant chemotherapy and assessing its utility as an early response biomarker in patients with platinum-sensitive relapse due to receive therapy with carboplatin. Scanning measurements will be correlated with histopathological markers in tumour samples in order to link the biomarker with response mechanisms.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: Yes

Locations

Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom

Queen Elizabeth Hospital, Newcastle, Gateshead, United Kingdom

Mount Vernon Cancer Centre, Northwood, Middlesex, United Kingdom

The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

Singleton Hospital, Swansea, Wales, United Kingdom

Imperial College Healthcare NHS Trust, London, , United Kingdom

Contact Details

Name: Nandita deSouza, Professor

Affiliation: ICR

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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