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Brief Title: A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
Official Title: A Phase II, Open-Label, Multicenter, Platform Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
Study ID: NCT04931342
Brief Summary: This study will evaluate the efficacy and safety of multiple biomarker-selected treatments in patients with persistent or recurrent rare epithelial ovarian, fallopian tube, or primary peritoneal tumors. Enrollment will take place in two phases: a preliminary phase followed by a potential expansion phase.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Arizona Oncology - HOPE Wilmot, Tucson, Arizona, United States
Kaiser Permanente - Irvine, Irvine, California, United States
UCSF Helen Diller Family CCC, San Francisco, California, United States
Minnesota Oncology Hematology, Saint Paul, Minnesota, United States
Washington University School of Medicine; Dept of Medicine/Div of Medical Oncology, Saint Louis, Missouri, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Levine Cancer Institute, Charlotte, North Carolina, United States
Ohio State University, Columbus, Ohio, United States
University of Oklahoma Health Sciences Center; Stephenson Cancer Center, Oklahoma City, Oklahoma, United States
Northwest Cancer Specialists, P.C., Tigard, Oregon, United States
MD Anderson Cancer Center, Houston, Texas, United States
Texas Oncology - Gulf Coast, The Woodlands, Texas, United States
Huntsman Cancer Institute, Salt Lake City, Utah, United States
Virginia Oncology Associates, Norfolk, Virginia, United States
University of Washington - Seattle Cancer Care Alliance; Medical Oncology, Seattle, Washington, United States
Cabrini Hospital; Cabrini Foundation, Malvern, Victoria, Australia
Princess Margaret Cancer Center, Toronto, Ontario, Canada
McGill University Health Centre - Glen Site, Montreal, Quebec, Canada
Fakultni nemocnice Brno Bohunice, Brno, , Czechia
Gynekologicko-porodnicka klinika, Prague, , Czechia
CHU Besançon - Hôpital Jean Minjoz, Besançon Cedex, , France
Institut Bergonie; Oncologie, Bordeaux, , France
Centre Francois Baclesse; Oncologie, Caen, , France
CENTRE LEON BERARD; Département d?Hématologie et d?Oncologie, Lyon, , France
Institut Régional du Cancer de Montpellier, Montpellier, , France
Groupe Hospitalier Diaconesses, Paris, , France
Centre Eugène Marquis, Rennes, , France
ICO - Site René Gauducheau, Saint Herblain, , France
Institut Claudius Regaud; Departement Oncologie Medicale, Toulouse, , France
Gustave Roussy, Villejuif, , France
Campus Virchow-Klinikum Charité; Centrum 17; Klinik für Gynäkologie, Berlin, , Germany
Universitätsklinikum "Carl Gustav Carus"; Frauenheilkunde und Geburtshilfe, Dresden, , Germany
Kliniken Essen-Mitte Evang. Huyssens-Stiftung, Klinik für Gynäkologie und gynäkologische Onkologie, Essen, , Germany
Universitätsklinikum Mannheim; Frauenklinik, Mannheim, , Germany
Klinikum der Universität München; Campus Großhadern; Klinik und Poliklinik für Frauenheilkunde, Muenchen, , Germany
Istituto Tumori Napoli;Unità Operativa Oncologia Medica Uro-Ginecologica, Napoli, Campania, Italy
Policlinico Universitario Agostino Gemelli, Roma, Lazio, Italy
IRCCS S. Raffaele; Ginecologia Oncologica, Milano, Lombardia, Italy
Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica, Milano, Lombardia, Italy
I.R.C.C. Candiolo; Oncologia Medica e Ematologia, Candiolo, Piemonte, Italy
A.O. U. Consorziale Policlinico di Bari; Oncologia Ginecologica, Bari, Puglia, Italy
Seoul National University Hospital, Seoul, , Korea, Republic of
Severance Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
LLC Medscan, Moskva, Moskovskaja Oblast, Russian Federation
FSBI "Federal Medical Research Center n.a. V.A.Almazov", Sankt-peterburg, Sankt Petersburg, Russian Federation
Chelyabisnk regional clinical center for oncology and nuclear medicine, Chelyabinsk, Sverdlovsk, Russian Federation
Institutio Catalan De Oncologia, Badalona, Barcelona, Spain
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario La Paz; Servicio de Oncologia, Madrid, , Spain
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Malaga, , Spain
Hôpitaux Universitaires de Genève; Département d'oncologie, Genève, , Switzerland
Adana Baskent University Medical Faculty; Oncology, Adana, , Turkey
Baskent Universitesi Ankara Hastanesi; Tıbbi Onkoloji Bölümü, Ankara, , Turkey
Koc University Medical Faculty; Department of Gynecology & Obstetrics, Istanbul, , Turkey
Western General Hospital; Edinburgh Cancer Center, Edinburgh, , United Kingdom
University College London Hospitals NHS Foundation Trust - University College Hospital, London, , United Kingdom
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR