Spots Global Cancer Trial Database for Hypodontia and Ovarian Cancer
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Trial Identification
Brief Title: Hypodontia and Ovarian Cancer
Official Title: Hypodontia and Ovarian Cancer - the Connection Between Dental Agenesis and Epithelial Cancers, Especially Ovarian Cancer.
Study ID: NCT01470235
Interventions
Study Description
Brief Summary: The purpose of this project is to examine whether the risk of developing ovarian cancer is increased in Danish women with congenital missing teeth as a result of their failure to develop (hypodontia). Should this prove to be the case, these women could be offered regular clinical controls and prophylactic removal of their ovaries when menopause enters and the ovaries are no longer functional (producing hormones). If there is a connection between congenital hypodontia and the development of different types of cancer, the investigators will perform a genetic screening in families with increased risk of cancer and hypodontia for changes in relevant genes, based on the current literature. The investigators hereby search for new genes, which in a changed form leads to an increased risk of cancer and thereby enables us to perform genetic screening in risk families.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Aarhus University Hospital, Skejby, Aarhus, Denmark
Copenhagen University Hospital, Copenhagen Ø, Copenhagen, Denmark
Contact Details
Name: Jan Blaakaer, Professor, MD, DMSc
Affiliation: Aarhus University Hospital
Role: STUDY_DIRECTOR
Name: Maria Cathrine C. V. Schmidt, MD, Ph.d.-student
Affiliation: Aarhus University Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Charlotte Soegaard, MD, ph.d.
Affiliation: Aarhus University Hospital
Role: STUDY_CHAIR
Name: Lone Sunde, Associate Professor, PhD
Affiliation: Aarhus University Hospital
Role: STUDY_CHAIR
Name: Claus Hoegdall, Professor
Affiliation: Copenhagen University Hospital at Herlev
Role: STUDY_CHAIR
Name: Michala O. Lexner, Dentist, PhD
Affiliation:
Role: STUDY_CHAIR
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