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Spots Global Cancer Trial Database for Efficacy and Safety of Pazopanib Monotherapy After First Line Chemotherapy in Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

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Trial Identification

Brief Title: Efficacy and Safety of Pazopanib Monotherapy After First Line Chemotherapy in Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Official Title: A Phase III Study to Evaluate the Efficacy and Safety of Pazopanib Monotherapy Versus Placebo in Women Who Have Not Progressed After First Line Chemotherapy for Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Study ID: NCT00866697

Conditions

Ovarian Cancer

Interventions

Pazopanib

Placebo

Study Description

Brief Summary: This was a study to determine whether therapy with pazopanib was effective and safe in women with epithelial ovarian, fallopian tube, or primary peritoneal cancer whose cancer had not progressed on first line chemotherapy.

Detailed Description: This was a randomized, two-arm, placebo controlled, double-blind, multicenter, intergroup Phase III study in women with non-bulky FIGO (International Federation of Gynecology and Obstetrics) Stage II - IV ovarian, fallopian tube, or primary peritoneal cancer that had not progressed (i.e., complete response (CR), partial response (PR), stable disease (SD) after completing their first-line chemotherapy for advanced ovarian cancer. Approximately 900 subjects were to be enrolled into the study. Study was closed following 3rd overall survival (OS) interim analysis as planned per protocol, which confirmed futility.

Keywords

fallopian tube cancer

pazopanib

anti-angiogenesis

ovarian cancer

primary peritoneal cancer

tyrosine kinase inhibitors

gynecologic cancer

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Novartis Investigative Site, Anaheim, California, United States

Novartis Investigative Site, Baldwin Park, California, United States

Novartis Investigative Site, Bellflower, California, United States

Novartis Investigative Site, Duarte, California, United States

Novartis Investigative Site, Fontana, California, United States

Novartis Investigative Site, Hayward, California, United States

Novartis Investigative Site, Irvine, California, United States

Novartis Investigative Site, Long Beach, California, United States

Novartis Investigative Site, Los Angeles, California, United States

Novartis Investigative Site, Oakland, California, United States

Novartis Investigative Site, Ontario, California, United States

Novartis Investigative Site, Orange, California, United States

Novartis Investigative Site, Panorama City, California, United States

Novartis Investigative Site, Riverside, California, United States

Novartis Investigative Site, Roseville, California, United States

Novartis Investigative Site, Sacramento, California, United States

Novartis Investigative Site, San Diego, California, United States

Novartis Investigative Site, San Francisco, California, United States

Novartis Investigative Site, San Jose, California, United States

Novartis Investigative Site, Santa Clara, California, United States

Novartis Investigative Site, South San Francisco, California, United States

Novartis Investigative Site, Vallejo, California, United States

Novartis Investigative Site, Walnut Creek, California, United States

Novartis Investigative Site, Woodland Hills, California, United States

Novartis Investigative Site, Augusta, Georgia, United States

Novartis Investigative Site, Morristown, New Jersey, United States

Novartis Investigative Site, Bronx, New York, United States

Novartis Investigative Site, New York, New York, United States

Novartis Investigative Site, Houston, Texas, United States

Novartis Investigative Site, Annandale, Virginia, United States

Novartis Investigative Site, Camperdown, New South Wales, Australia

Novartis Investigative Site, Liverpool, New South Wales, Australia

Novartis Investigative Site, Randwick, New South Wales, Australia

Novartis Investigative Site, Waratah, New South Wales, Australia

Novartis Investigative Site, Herston, Queensland, Australia

Novartis Investigative Site, South Brisbane, Queensland, Australia

Novartis Investigative Site, Adelaide, South Australia, Australia

Novartis Investigative Site, Hobart, Tasmania, Australia

Novartis Investigative Site, Malvern, Victoria, Australia

Novartis Investigative Site, Parkville, Victoria, Australia

Novartis Investigative Site, Wodonga, Victoria, Australia

Novartis Investigative Site, Nedlands, Western Australia, Australia

Novartis Investigative Site, Melbourne, , Australia

Novartis Investigative Site, Graz, , Austria

Novartis Investigative Site, Innsbruck, , Austria

Novartis Investigative Site, Klagenfurt Am Woerthersee, , Austria

Novartis Investigative Site, Korneuburg, , Austria

Novartis Investigative Site, Krems, , Austria

Novartis Investigative Site, Leoben, , Austria

Novartis Investigative Site, Linz, , Austria

Novartis Investigative Site, Oberpullendorf, , Austria

Novartis Investigative Site, Wien, , Austria

Novartis Investigative Site, Bonheiden, , Belgium

Novartis Investigative Site, Duffel, , Belgium

Novartis Investigative Site, Gent, , Belgium

Novartis Investigative Site, Kortrijk, , Belgium

Novartis Investigative Site, Leuven, , Belgium

Novartis Investigative Site, Libramont, , Belgium

Novartis Investigative Site, Liege, , Belgium

Novartis Investigative Site, Namur, , Belgium

Novartis Investigative Site, Oostende, , Belgium

Novartis Investigative Site, Guangzhou, Guangdong, China

Novartis Investigative Site, Nanjing, Jiangsu, China

Novartis Investigative Site, Shenyang, Liaoning, China

Novartis Investigative Site, Jinan, Shandong, China

Novartis Investigative Site, Hangzhou, Zhejiang, China

Novartis Investigative Site, Beijing, , China

Novartis Investigative Site, Shanghai, , China

Novartis Investigative Site, Tianjin, , China

Novartis Investigative Site, Aalborg, , Denmark

Novartis Investigative Site, Herlev, , Denmark

Novartis Investigative Site, Herning, , Denmark

Novartis Investigative Site, Koebenhavn Oe, , Denmark

Novartis Investigative Site, ANGERS Cedex 2, , France

Novartis Investigative Site, Avignon cedex, , France

Novartis Investigative Site, Besancon Cedex, , France

Novartis Investigative Site, Bordeaux, , France

Novartis Investigative Site, Bourg en Bresse Cedex, , France

Novartis Investigative Site, Brest Cedex, , France

Novartis Investigative Site, Brive La Gaillarde, , France

Novartis Investigative Site, Caen Cedex 05, , France

Novartis Investigative Site, Clermont-Ferrand cedex, , France

Novartis Investigative Site, Colmar Cedex, , France

Novartis Investigative Site, Dax Cedex, , France

Novartis Investigative Site, Grenoble Cedex 09, , France

Novartis Investigative Site, Grenoble Cedex, , France

Novartis Investigative Site, La Roche sur Yon Cedex 9, , France

Novartis Investigative Site, Le Chesnay Cedex, , France

Novartis Investigative Site, Le Mans, , France

Novartis Investigative Site, Lille Cedex, , France

Novartis Investigative Site, Lille, , France

Novartis Investigative Site, Lorient cedex, , France

Novartis Investigative Site, Lyon Cedex 08, , France

Novartis Investigative Site, Marseille cedex, , France

Novartis Investigative Site, Metz Cedex 03, , France

Novartis Investigative Site, Mont de Marsan, , France

Novartis Investigative Site, Montpellier cedex 5, , France

Novartis Investigative Site, Montpellier, , France

Novartis Investigative Site, Mougins Cedex 2, , France

Novartis Investigative Site, Nancy, , France

Novartis Investigative Site, Nantes Cedex 2, , France

Novartis Investigative Site, Nice Cedex 2, , France

Novartis Investigative Site, Nimes, , France

Novartis Investigative Site, Orleans, , France

Novartis Investigative Site, Paris cedex 05, , France

Novartis Investigative Site, Paris Cedex 10, , France

Novartis Investigative Site, Paris Cedex 20, , France

Novartis Investigative Site, Paris Cedex 4, , France

Novartis Investigative Site, Paris, , France

Novartis Investigative Site, Perigueux Cedex, , France

Novartis Investigative Site, Perin Sur Mer, , France

Novartis Investigative Site, Pierre-Benite Cedex, , France

Novartis Investigative Site, Reims Cedex, , France

Novartis Investigative Site, Rouen, , France

Novartis Investigative Site, Saint-Herblain, , France

Novartis Investigative Site, Saint-Priest en Jarez, , France

Novartis Investigative Site, Strasbourg Cedex, , France

Novartis Investigative Site, Strasbourg, , France

Novartis Investigative Site, Suresnes, , France

Novartis Investigative Site, Thonon-les-Bains, , France

Novartis Investigative Site, Vandoeuvre-Les-Nancy, , France

Novartis Investigative Site, Esslingen, Baden-Wuerttemberg, Germany

Novartis Investigative Site, Freiburg, Baden-Wuerttemberg, Germany

Novartis Investigative Site, Karlsruhe, Baden-Wuerttemberg, Germany

Novartis Investigative Site, Mannheim, Baden-Wuerttemberg, Germany

Novartis Investigative Site, Mutlangen, Baden-Wuerttemberg, Germany

Novartis Investigative Site, Reutlingen, Baden-Wuerttemberg, Germany

Novartis Investigative Site, Schwaebisch Hall, Baden-Wuerttemberg, Germany

Novartis Investigative Site, Tuebingen, Baden-Wuerttemberg, Germany

Novartis Investigative Site, Ulm, Baden-Wuerttemberg, Germany

Novartis Investigative Site, Bayreuth, Bayern, Germany

Novartis Investigative Site, Coburg, Bayern, Germany

Novartis Investigative Site, Deggendorf, Bayern, Germany

Novartis Investigative Site, Ebersberg, Bayern, Germany

Novartis Investigative Site, Eggenfelden, Bayern, Germany

Novartis Investigative Site, Fuerth, Bayern, Germany

Novartis Investigative Site, Muenchen, Bayern, Germany

Novartis Investigative Site, Schweinfurt, Bayern, Germany

Novartis Investigative Site, Darmstadt, Hessen, Germany

Novartis Investigative Site, Frankfurt am Main, Hessen, Germany

Novartis Investigative Site, Frankfurt, Hessen, Germany

Novartis Investigative Site, Fulda, Hessen, Germany

Novartis Investigative Site, Kassel, Hessen, Germany

Novartis Investigative Site, Lich, Hessen, Germany

Novartis Investigative Site, Limburg, Hessen, Germany

Novartis Investigative Site, Marburg, Hessen, Germany

Novartis Investigative Site, Offenbach, Hessen, Germany

Novartis Investigative Site, Wiesbaden, Hessen, Germany

Novartis Investigative Site, Greifswald, Mecklenburg-Vorpommern, Germany

Novartis Investigative Site, Rostock, Mecklenburg-Vorpommern, Germany

Novartis Investigative Site, Braunschweig, Niedersachsen, Germany

Novartis Investigative Site, Cuxhaven, Niedersachsen, Germany

Novartis Investigative Site, Georgsmarienhuette, Niedersachsen, Germany

Novartis Investigative Site, Gifhorn, Niedersachsen, Germany

Novartis Investigative Site, Goettingen, Niedersachsen, Germany

Novartis Investigative Site, Goslar, Niedersachsen, Germany

Novartis Investigative Site, Hannover, Niedersachsen, Germany

Novartis Investigative Site, Hildesheim, Niedersachsen, Germany

Novartis Investigative Site, Leer, Niedersachsen, Germany

Novartis Investigative Site, Lueneburg, Niedersachsen, Germany

Novartis Investigative Site, Oldenburg, Niedersachsen, Germany

Novartis Investigative Site, Salzgitter, Niedersachsen, Germany

Novartis Investigative Site, Wolfsburg, Niedersachsen, Germany

Novartis Investigative Site, Bonn, Nordrhein-Westfalen, Germany

Novartis Investigative Site, Detmold, Nordrhein-Westfalen, Germany

Novartis Investigative Site, Dortmund, Nordrhein-Westfalen, Germany

Novartis Investigative Site, Duesseldorf, Nordrhein-Westfalen, Germany

Novartis Investigative Site, Essen, Nordrhein-Westfalen, Germany

Novartis Investigative Site, Koeln, Nordrhein-Westfalen, Germany

Novartis Investigative Site, Neuss, Nordrhein-Westfalen, Germany

Novartis Investigative Site, Troisdorf, Nordrhein-Westfalen, Germany

Novartis Investigative Site, Viersen, Nordrhein-Westfalen, Germany

Novartis Investigative Site, Mainz, Rheinland-Pfalz, Germany

Novartis Investigative Site, Trier, Rheinland-Pfalz, Germany

Novartis Investigative Site, Halle, Sachsen-Anhalt, Germany

Novartis Investigative Site, Magdeburg, Sachsen-Anhalt, Germany

Novartis Investigative Site, Quedlinburg, Sachsen-Anhalt, Germany

Novartis Investigative Site, Salzwedel, Sachsen-Anhalt, Germany

Novartis Investigative Site, Chemnitz, Sachsen, Germany

Novartis Investigative Site, Dresden, Sachsen, Germany

Novartis Investigative Site, Leipzg, Sachsen, Germany

Novartis Investigative Site, Radebeul, Sachsen, Germany

Novartis Investigative Site, Zwickau, Sachsen, Germany

Novartis Investigative Site, Flensburg, Schleswig-Holstein, Germany

Novartis Investigative Site, Kiel, Schleswig-Holstein, Germany

Novartis Investigative Site, Luebeck, Schleswig-Holstein, Germany

Novartis Investigative Site, Gera, Thueringen, Germany

Novartis Investigative Site, Nordhausen, Thueringen, Germany

Novartis Investigative Site, Suhl, Thueringen, Germany

Novartis Investigative Site, Berlin, , Germany

Novartis Investigative Site, Hamburg, , Germany

Novartis Investigative Site, Hong Kong, , Hong Kong

Novartis Investigative Site, Kowloon, , Hong Kong

Novartis Investigative Site, Dublin, , Ireland

Novartis Investigative Site, Waterford, , Ireland

Novartis Investigative Site, Wilton, Cork, , Ireland

Novartis Investigative Site, Potenza, Basilicata, Italy

Novartis Investigative Site, Avellino, Campania, Italy

Novartis Investigative Site, Napoli, Campania, Italy

Novartis Investigative Site, Bologna, Emilia-Romagna, Italy

Novartis Investigative Site, Carpi (MO), Emilia-Romagna, Italy

Novartis Investigative Site, Faenza (RA), Emilia-Romagna, Italy

Novartis Investigative Site, Reggio Emilia, Emilia-Romagna, Italy

Novartis Investigative Site, Aviano (PN), Friuli-Venezia-Giulia, Italy

Novartis Investigative Site, Roma, Lazio, Italy

Novartis Investigative Site, Brescia, Lombardia, Italy

Novartis Investigative Site, Como, Lombardia, Italy

Novartis Investigative Site, Milano, Lombardia, Italy

Novartis Investigative Site, Monza, Lombardia, Italy

Novartis Investigative Site, Sondrio, Lombardia, Italy

Novartis Investigative Site, Varese, Lombardia, Italy

Novartis Investigative Site, Campobasso, Molise, Italy

Novartis Investigative Site, Torino, Piemonte, Italy

Novartis Investigative Site, Bari, Puglia, Italy

Novartis Investigative Site, Palermo, Sicilia, Italy

Novartis Investigative Site, Perugia, Umbria, Italy

Novartis Investigative Site, Vicenza, Veneto, Italy

Novartis Investigative Site, Ehime, , Japan

Novartis Investigative Site, Fukuoka, , Japan

Novartis Investigative Site, Hiroshima, , Japan

Novartis Investigative Site, Hokkaido, , Japan

Novartis Investigative Site, Iwate, , Japan

Novartis Investigative Site, Kagoshima, , Japan

Novartis Investigative Site, Miyagi, , Japan

Novartis Investigative Site, Osaka, , Japan

Novartis Investigative Site, Saitama, , Japan

Novartis Investigative Site, Tokyo, , Japan

Novartis Investigative Site, Tottori, , Japan

Novartis Investigative Site, Goyang-si, Gyeonggi-do, , Korea, Republic of

Novartis Investigative Site, Kangnam-Ku ,Seoul, , Korea, Republic of

Novartis Investigative Site, Seoul, , Korea, Republic of

Novartis Investigative Site, Bergen, , Norway

Novartis Investigative Site, Oslo, , Norway

Novartis Investigative Site, Stavanger, , Norway

Novartis Investigative Site, Tromso, , Norway

Novartis Investigative Site, Alcorcon (Madrid), , Spain

Novartis Investigative Site, Barcelona, , Spain

Novartis Investigative Site, Cartagena (Murcia), , Spain

Novartis Investigative Site, Elche, , Spain

Novartis Investigative Site, Lerida, , Spain

Novartis Investigative Site, Madrid, , Spain

Novartis Investigative Site, Murcia (El Palmar), , Spain

Novartis Investigative Site, Palma de Mallorca, , Spain

Novartis Investigative Site, Pamplona, , Spain

Novartis Investigative Site, Sabadell (Barcelona), , Spain

Novartis Investigative Site, San Sebastian, , Spain

Novartis Investigative Site, Santiago de Compostela, , Spain

Novartis Investigative Site, Terrassa, , Spain

Novartis Investigative Site, Valencia, , Spain

Novartis Investigative Site, Zaragoza, , Spain

Novartis Investigative Site, Linkoping, , Sweden

Novartis Investigative Site, Lund, , Sweden

Novartis Investigative Site, Stockholm, , Sweden

Novartis Investigative Site, Uppsala, , Sweden

Novartis Investigative Site, Taipei, , Taiwan

Contact Details

Name: Novartis Pharmaceuticals

Affiliation: Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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