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Brief Title: Diffusion-weighted Imaging Study in Cancer of the Ovary
Official Title: Assessing Treatment Response of Peritoneal Metastases in Ovarian Cancer Using Diffusion Weighted Magnetic Resonance Imaging.
Study ID: NCT01505829
Brief Summary: This project seeks to develop a quantitative imaging biomarker for evaluating and monitoring treatment response in ovarian cancer metastases and assess its potential in monitoring treatment response. This will involve standardising DW-MRI for the abdomen and pelvis across multiple centres and platforms, assessing reproducibility of the measurement in patients planned for neoadjuvant chemotherapy and assessing its utility as an early response biomarker in patients with platinum-sensitive relapse due to receive therapy with carboplatin. Scanning measurements will be correlated with histopathological markers in tumour samples in order to link the biomarker with response mechanisms.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: Yes
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom
Queen Elizabeth Hospital, Newcastle, Gateshead, United Kingdom
Mount Vernon Cancer Centre, Northwood, Middlesex, United Kingdom
The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
Singleton Hospital, Swansea, Wales, United Kingdom
Imperial College Healthcare NHS Trust, London, , United Kingdom
Name: Nandita deSouza, Professor
Affiliation: ICR
Role: PRINCIPAL_INVESTIGATOR