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Brief Title: Platine, Avastin and OLAparib in 1st Line
Official Title: Randomized, Double-Blind, Phase III Trial Olaparib vs. Placebo Patients With Advanced FIGO Stage IIIB-IV High Grade Serious or Endometrioid Ovarian, Fallopian Tube, or Peritoneal Cancer Treated Standard First-Line Treatment
Study ID: NCT02477644
Brief Summary: Randomized, Double-Blind, Phase III Trial of Olaparib vs. Placebo in Patients with Advanced FIGO Stage IIIB - IV High Grade Serous or Endometrioid Ovarian, Fallopian Tube, or Peritoneal Cancer treated with standard First-Line Treatment, Combining Platinum-Taxane Chemotherapy and Bevacizumab Concurrent with Chemotherapy and in Maintenance.
Detailed Description: Patients with advanced FIGO stage IIIB - IV high grade serous or endometrioid ovarian, fallopian tube, or peritoneal cancer treated with standard first-line treatment, combining platinum-taxane chemotherapy and bevacizumab concurrent with chemotherapy and in maintenance.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
KH der Barmherzigen Brüder Graz, Graz, , Austria
Medical University of Graz, Graz, , Austria
Medical University of Innsbruck, Innsbruck, , Austria
Landeskrankenhaus Salzburg, Salzburg, , Austria
Medical University of Vienna, Vienna, , Austria
Krankenhaus Hietzing, Vienna, , Austria
Institut Jules Bordet, Bruxelles, , Belgium
Antwerp University Hospital, Edegem, , Belgium
UZ Gasthuisberg, Leuven, , Belgium
Hôpital de la Citadelle, Liège, , Belgium
Clinique et maternité Sainte Elisabeth, Namur, , Belgium
CHU Dinant Godinne, Yvoir, , Belgium
Rigshospitalet, Copenhagen, , Denmark
Herlev Hospital, Herlev, , Denmark
Kuopio University Hospital, Kuopio, , Finland
Oulu University Hospital, Oulu, , Finland
Tampere University Hospital, Tampere, , Finland
Turku University Hospital, Turku, , Finland
Hôpital Européen Georges Pompidou, Paris, Ilhe De France, France
ICO Paul Papin, Angers, , France
Institut Sainte-Catherine, Avignon, , France
Hôpital Jean Minjoz, Besancon, , France
Institut Bergonié, Bordeaux, , France
Polyclinique Bordeaux Nord, Bordeaux, , France
Centre François Baclesse, Caen, , France
Centre Jean Perrin, Clermont-ferrand, , France
Centre Georges François Leclerc, Dijon, , France
Groupe Hospitalier Mutualiste de Grenoble, Grenoble, , France
Centre Hospitalier Départemental Les Oudairies, La Roche-sur-yon, , France
Hôpital Michallon - Centre Hospitalier Universitaire de Grenoble, La Tronche, , France
Centre Jean Bernard - Clinique Victor Hugo, Le Mans, , France
Centre Hospitalier Régional Universitaire de Lille - Hôpital Huriez, Lille, , France
Centre Oscar Lambret, Lille, , France
Centre Léon Bérard, Lyon, , France
Institut Paoli Calmettes, Marseille, , France
Hôpital de Mont-de-Marsan, Mont-de-marsan, , France
ICM Val d'Aurelle, Montpellier, , France
Centre Azuréen de Cancérologie, Mougins, , France
Centre Catherine de Sienne - Group confluent, Nantes, , France
Centre Antoine Lacassagne, Nice, , France
Centre Hospitalier Régional d'Orléans, Orleans, , France
Institut Curie - Hopital Claudius Régaud, Paris, , France
Hôpital des Diaconesses, Paris, , France
Hôpital Cochin, Paris, , France
Hopital Tenon, Paris, , France
Groupe Hospitalier Saint-Joseph, Paris, , France
Clinique Francheville, Perigueux, , France
Centre Hospitalier Lyon Sud, Pierre-benite, , France
Centre CARIO - HPCA, Plérin, , France
Hôpital de la Milétrie - CHU de Poitiers - Pôle Régional de Cancérologie, Poitiers, , France
Centre Eugène Marquis, Rennes, , France
Centre Henri Becquerel, Rouen, , France
Hôpital René Huguenin, Institut Curie, Saint-cloud, , France
ICO Centre René Gauducheau, Saint-herblain, , France
Centre de Radiothérapie - Clinique Sainte-Anne, Strasbourg, , France
Centre Paul Strauss, Strasbourg, , France
Hôpitaux Universitaires de Strasbourg, Strasbourg, , France
Institut Claudius Regaud, Toulouse, , France
Clinique Pasteur - ONCOSUD, Toulouse, , France
ICL Institut de Cancérologie de Lorraine, Vandoeuvre-les-nancy, , France
Institut Gustave Roussy, Villejuif, , France
Klinikum Aschaffenburg, Aschaffenburg, , Germany
Klinikum Augsburg, Augsburg, , Germany
Hochtaunus-Kliniken, Bad Homburg, , Germany
Praxisklinik Krebsheilkunde für Frauen, Berlin, , Germany
HELIOS Klinikum Berlin-Buch, Berlin, , Germany
Charité - Universitätsmedizin Berlin (CVK), Berlin, , Germany
Onkologie Bottrop, Bottrop, , Germany
GYNAEKOLOGICUM Bremen, Bremen, , Germany
Städtisches Klinikum Dessau, Dessau, , Germany
Universitätsklinikum Carl Gustav Carus, Dresden, , Germany
Evangelisches Krankenhaus Düsseldorf, Düsseldorf, , Germany
Universitätsklinikum Düsseldorf, Düsseldorf, , Germany
Universitätsfrauenklinik Erlangen, Erlangen, , Germany
Kliniken Essen Mitte, Essen, , Germany
Universitätsklinikum Essen, Essen, , Germany
Klinikum Esslingen, Esslingen, , Germany
Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt, , Germany
Klinikum Frankfurt Höchst, Frankfurt, , Germany
Universitätsfrauenklinik Freiburg, Freiburg, , Germany
Universitätsmedizin Greifswald, Greifswald, , Germany
Universitäts-Frauenklinik Göttingen, Göttingen, , Germany
Klinkum Gütersloh, Gütersloh, , Germany
Universitätsklinikum Halle, Halle, , Germany
Universitätsklinikum Hamburg-Eppendorf, Hamburg, , Germany
Albertinen Krankenhaus, Hamburg, , Germany
Gynäkologisch-Onkologische Praxis Hannover, Hannover, , Germany
Medizinische Hochschule Hannover, Hannover, , Germany
Universitätsklinikum Heidelberg, Heidelberg, , Germany
Universitätsklinikum Jena, Jena, , Germany
St. Vincentius Kliniken, Karlsruhe, , Germany
Klinikum Kassel, Kassel, , Germany
Universitätsklinikum Schleswig-Holstein, Kiel, , Germany
Klinikum Konstanz, Konstanz, , Germany
HELIOS Klinikum Krefeld, Krefeld, , Germany
Universitätsfrauenklinik Köln, Köln, , Germany
St. Elisabeth Krankenhaus, Köln, , Germany
Klinikum Ludwigsburg, Ludwigsburg, , Germany
Universitätsklinikum Schleswig-Holstein, Lübeck, , Germany
Universitätsklinikum Gießen und Marburg, Marburg, , Germany
Johannes Wesling Klinikum, Minden, , Germany
Klinikum der Universität München, München, , Germany
Klinikum rechts der Isar, München, , Germany
Universitätsklinikum Münster, Münster, , Germany
Kliniken des Landkreises Neumarkt, Neumarkt, , Germany
Sana Klinikum Offenbach, Offenbach, , Germany
Ortenau Klinikum, Offenburg, , Germany
Onkologie Ravensburg, Ravensburg, , Germany
Universitätsfrauenklinik Regensburg, Regensburg, , Germany
Klinikum am Steinenberg, Reutlingen, , Germany
ROMed Klinikum Rosenheim, Rosenheim, , Germany
Klinikum Südstadt, Rostock, , Germany
Robert-Bosch-Krankenhaus, Stuttgart, , Germany
Universitäts-Frauenklinik Tübingen, Tübingen, , Germany
Universitätsklinikum Ulm, Ulm, , Germany
HELIOS Dr. Horst Schmidt Kliniken, Wiesbaden, , Germany
Marien Hospital Witten, Witten, , Germany
amO Wolfsburg, Wolfsburg, , Germany
Klinikum Worms, Worms, , Germany
Universitätsklinikum Würzburg, Würzburg, , Germany
Centro Riferimento Oncologico, Aviano, , Italy
Policlinico S.Orsola-Malpighi, Bologna, , Italy
Spedali Civili-Università di Brescia, Brescia, , Italy
Ospedale Senatore Antonio Perrino, Brindisi, , Italy
EO Ospedali Galliera, Genova, , Italy
Ospedale San Luca, Lucca, , Italy
Istituto Nazionale Tumori, Milano, , Italy
Istituto Europeo di Oncologia, Milano, , Italy
Istituto Nazionale Tumori - IRCCS Pascale, Napoli, , Italy
Istituto Oncologico Veneto, Padova, , Italy
Ospedale Santa Maria della Misericordia, Perugia, , Italy
Ospedale Santa Chiara, Pisa, , Italy
AO ASL 4 - Ospedale di Prato, Prato, , Italy
Arcispedale S. M. Nuova, Reggio Emilia, , Italy
Istituto Regina Elena, Roma, , Italy
Policlinico Umberto I La Sapienza, Roma, , Italy
Policlinico Universitario Gemelli Università Cattolica del Sacro Cuore, Roma, , Italy
Ospedale S. Anna, Torino, , Italy
Ospedale Mauriziano, Torino, , Italy
Ospedale Santa Chiara, Trento, , Italy
Ehime University Hospital, Ehime, , Japan
Hyogo Cancer Center, Hyogo, , Japan
University of Tsukuba Hospital, Ibaraki, , Japan
Kagoshima University Medical And Dental Hospital, Kagoshima, , Japan
Saitama Medical University International Medical Center, Saitama, , Japan
Jichi Medical University Hospital, Tochigi, , Japan
National Cancer Center Hospital, Tokyo, , Japan
Centre Hospitalier Princesse Grace, Monaco, , Monaco
H. U. Fundación Alcorcón, Alcorcón, , Spain
H. de la Santa Creu i Sant Pau, Barcelona, , Spain
C.S. Parc Taulí, Barcelona, , Spain
H. U. Reina Sofía, Córdoba, , Spain
H.U. Arnau de Vilanova, Lleida, , Spain
MD Anderson Cancer Center Madrid, Madrid, , Spain
H. U. Ramón y Cajal, Madrid, , Spain
H. U. 12 de Octubre, Madrid, , Spain
H.U. Central de Asturias, Oviedo, , Spain
Complejo Hospitalario de Navarra, Pamplona, , Spain
H. General Universitario de Valencia, Valencia, , Spain
H. U. P. La Fe, Valencia, , Spain
Instituto Valenciano de Oncología, València, , Spain
H. U. Miguel Servet, Zaragoza, , Spain
Linköping University Hospital, Linköping, , Sweden
Name: Isabelle RAY COQUARD, MD, PhD
Affiliation: Centre Leon Berard
Role: PRINCIPAL_INVESTIGATOR