Spots Global Cancer Trial Database for Phase I/IIa Study for AZD5335 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Solid Tumors
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Trial Identification
Brief Title: Phase I/IIa Study for AZD5335 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Solid Tumors
Official Title: FONTANA: A Modular Phase I/IIa, Open-label, Multi-center Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Ascending Doses of AZD5335 Monotherapy and in Combination With Anti-cancer Agents in Participants With Solid Tumors.
Study ID: NCT05797168
Study Description
Brief Summary: This research is designed to determine if experimental treatment with Antibody-drug conjugate, AZD5335, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced tumors
Detailed Description: This study is a Phase I/IIa modular, open-label, multi-center study of AZD5335 administered either as monotherapy or in combination with other anti-cancer agents in participants with advanced solid malignancies
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Duarte, California, United States
Research Site, Irvine, California, United States
Research Site, La Jolla, California, United States
Research Site, Aurora, Colorado, United States
Research Site, Louisville, Kentucky, United States
Research Site, Boston, Massachusetts, United States
Research Site, Columbus, Ohio, United States
Research Site, Portland, Oregon, United States
Research Site, Providence, Rhode Island, United States
Research Site, Providence, Rhode Island, United States
Research Site, Houston, Texas, United States
Research Site, Liverpool, , Australia
Research Site, Melbourne, , Australia
Research Site, Edmonton, Alberta, Canada
Research Site, London, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Montréal, Quebec, Canada
Research Site, Chengdu, , China
Research Site, Chongqing, , China
Research Site, Jinan, , China
Research Site, Xi'an, , China
Research Site, Zhengzhou, , China
Research Site, Haifa, , Israel
Research Site, Ramat Gan, , Israel
Research Site, Kashiwa, , Japan
Research Site, Tokyo, , Japan
Research Site, Barcelona, , Spain
Research Site, Madrid, , Spain
Research Site, Madrid, , Spain
Research Site, Málaga, , Spain
Research Site, Taichung, , Taiwan
Research Site, Tainan City, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Cambridge, , United Kingdom
Research Site, Glasgow, Scotland, , United Kingdom
Research Site, London, , United Kingdom
Research Site, Sutton, , United Kingdom
Contact Details
Name: Funda Meric-Bernstam, MD
Affiliation: UT MD Anderson Cancer Center
Role: PRINCIPAL_INVESTIGATOR
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