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Spots Global Cancer Trial Database for Biobehavioral-Cytokine Interactions in Ovarian Cancer

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Biobehavioral-Cytokine Interactions in Ovarian Cancer

Official Title: Biobehavioral-Cytokine Interactions in Ovarian Cancer

Study ID: NCT01113112

Interventions

Study Description

Brief Summary: The purpose of this study is to understand relationships between behavioral factors, hormones, and chemicals produced by the body that may help tumor growth in ovarian cancer.

Detailed Description: Ovarian cancer is the second most common gynecologic cancer. Because of low rates of survival for the majority of ovarian cancer patients, identification of factors contributing to tumor progression is of paramount importance. Epidemiologic studies have suggested an association between biobehavioral factors such as life stress, depression, low social support and cancer progression. Direct links have been demonstrated between biobehavioral factors and cytokines supporting angiogenesis, the formation of new blood vessels that enhance tumor growth and progression. However, little is known regarding tumor associated macrophages (TAM) and interactions between TAM tumor cells in a way that favors tumor growth, but there is preliminary data indicating that ovarian cancer patients with higher levels of depressive symptoms and life stress have greater TAM production of matrix metalloproteinase-9, a key molecule promoting angiogenesis and tumor invasion. We also have preliminary data that ovarian cancer patients with high levels of depressive symptoms accompanied by low social support have greater tumor expression of a number of genes related to inflammation and tumor progression.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Contact Details

Name: Susan Lutgendorf, Ph.D.

Affiliation: University of Iowa

Role: PRINCIPAL_INVESTIGATOR

Name: Premal Thaker, MD

Affiliation: Washington University School of Medicine

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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