Spots Global Cancer Trial Database for Improved Diagnosis of Ovarian Cancer by Use of Circulating Tumor DNA as a Biomarker
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Trial Identification
Brief Title: Improved Diagnosis of Ovarian Cancer by Use of Circulating Tumor DNA as a Biomarker
Official Title: Improved Diagnosis of Ovarian Cancer by Use of Circulating Tumor DNA as a Biomarker
Study ID: NCT05763511
Interventions
Study Description
Brief Summary: This project investigates circulating tumor DNA (ctDNA) in patients with suspected ovarian malignancy. We hypothesize that measurement of ctDNA in women with suspected ovarian cancer can improve the diagnostic efficiency for preoperative differentiation between benign and malignant masses. Specifically, we hope to determine the diagnostic efficiency of ctDNA alone and ctDNA in combination with imaging modalities (ultrasonography, MRI, PET-CT) and CA 125 for preoperative differentiation between benign and malignant adnexal masses. Based on this, we hope to develop an improved diagnostic algorithm. The mutational profile and relation to tumour type, stage, treatment response and prognosis will be explored. Analyses of blood and tissue samples will be used to examine the disease development and biology. Blood samples, tumour tissue and data on imaging modalities as well as CA 125 will be collected prospectively in consecutive women referred to Aarhus University Hospital.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Department of Gynaecology and Obstetrics, Aarhus University Hospital, Aarhus, , Denmark
Contact Details
Name: Ina Marie Dueholm Hjorth, MD
Affiliation: University of Aarhus
Role: PRINCIPAL_INVESTIGATOR
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