Spots Global Cancer Trial Database for A Study of SGN-B7H4V in Advanced Solid Tumors
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Trial Identification
Brief Title: A Study of SGN-B7H4V in Advanced Solid Tumors
Official Title: A Phase 1 Study of SGN-B7H4V in Advanced Solid Tumors
Study ID: NCT05194072
Interventions
Study Description
Brief Summary: This study will test the safety of a drug called SGN-B7H4V in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to the body besides treating the disease. Participants will have cancer that has spread in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastatic). This study will have three parts. Parts A and B of the study will find out how much SGN-B7H4V should be given to participants. Part C will use the dose found in Parts A and B to find out how safe SGN-B7H4V is and if it works to treat solid tumor cancers.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Colorado Hospital / University of Colorado, Aurora, Colorado, United States
Sarah Cannon Research Institute at HealthONE - Denver, Denver, Colorado, United States
AdventHealth Cancer Institute, Celebration, Florida, United States
Mayo Clinic Florida, Jacksonville, Florida, United States
Florida Cancer Specialists - Lake Nona, Orlando, Florida, United States
Northwestern University, Chicago, Illinois, United States
Community Health Network, Indianapolis, Indiana, United States
South Texas Accelerated Research Therapeutics Midwest, Grand Rapids, Michigan, United States
Tennessee Oncology-Nashville/Sarah Cannon Research Institute, Nashville, Tennessee, United States
MD Anderson Cancer Center / University of Texas, Houston, Texas, United States
South Texas Accelerated Research Therapeutics, San Antonio, Texas, United States
South Texas Accelerated Research Therapeutics Mountain Region, West Valley City, Utah, United States
University of Ottawa / Ottawa General Hospital, Ottawa, Ontario, Canada
Charite Universitatsmedizin Berlin, Berlin, Other, Germany
Instituto Europeo di Oncologia, Milano, Other, Italy
Hospital Universitari Vall d'Hebron, Barcelona, Other, Spain
START Madrid-CIOCC_Hospital HM Sanchinarro, Madrid, Other, Spain
Sarah Cannon Research Institute UK, London, Other, United Kingdom
Contact Details
Name: Medical Monitor
Affiliation: Seagen Inc.
Role: STUDY_DIRECTOR
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