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Spots Global Cancer Trial Database for Development of Immunological Assays for the Evaluation of Tumor Antigen Specific Immunity

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Trial Identification

Brief Title: Development of Immunological Assays for the Evaluation of Tumor Antigen Specific Immunity

Official Title: Phase 0 Study for the Development of Immunological Assays for the Evaluation of WT-1, Survivin and HPV16 E7 Tumor Antigens Specific Immune Responses in Cancer Patients

Study ID: NCT02016833

Interventions

Blood Sampling

Study Description

Brief Summary: This study is a clinical study aiming at establishing immunological assays for the qualitative and quantitative evaluation of WT-1, Survivin and HPV16 E7-specific immune responses in cancer patients. Such a study will allow the development of suitable immunological tools to be used in assessing response in a subsequent phase I study aiming at evaluating therapeutic vaccine candidates targeting WT-1, Survivin and/or HPV16 E7-expressing tumors. In addition, this study will help defining the baseline cancer-associated immune responses in the selected patient population. Cervical and ovarian cancer patients, as well as leukemia patients, will be included in this study. WT-1, Survivin and HPV-specific immune responses will be monitored in these patients by ex vivo and cultured IFNg ELISpot as well as tetramer staining.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Peter MacCallum Cancer Center, Melbourne, Victoria, Australia

Contact Details

Name: Linda Mileshkin, MD

Affiliation: Peter MacCallum Cancer Centre, Australia

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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