Spots Global Cancer Trial Database for ABCB1 SNPs as Predictors of PIPN
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Trial Identification
Brief Title: ABCB1 SNPs as Predictors of PIPN
Official Title: ABCB1 Single Nucleotide Polymorphism Genotypes as Predictors of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer
Study ID: NCT05093023
Interventions
Study Description
Brief Summary: The study aim is to determine the allele frequencies of 1236 G\>A and 3435 G\>A in ABCB1 and study their association with the incidence and severity of paclitaxel-induced peripheral neuropathy while adjusting for other baseline covariates in Egyptian patients. Additionally, the study aimed at fitting and validating logistic regression models with the aforementioned SNPs evaluated in additive, dominant, overdominant, and recessive genetic models and performing diagnostics for the best model in terms of internal validity.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Nasser's Institute Hospital, Cairo, Aghakhan, Egypt
Contact Details
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