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Brief Title: Electron Beam Intraoperative Radiation Therapy Following Chemoradiation in Patients With Pancreatic Cancer With Vascular Involvement
Official Title: PACER (Pancreatic AdenoCarcinoma With Electron Intraoperative Radiation Therapy): A Phase II Study of Electron Beam Intraoperative Radiation Therapy Following Chemoradiation in Patients With Pancreatic Cancer With Vascular Involvement
Study ID: NCT03716531
Brief Summary: This research study is studying an intervention as a possible treatment for pancreatic cancer.
Detailed Description: In this research study, the investigators are researching how well IORT during surgery works in treating pancreatic cancer after 3-6 months of chemotherapy and external radiation therapy. IORT works by delivering radiation therapy to the tumor while reducing the amount of healthy tissue exposed to the radiation therapy. The investigators believe that the administration of IORT after 3-6 months of chemotherapy will help to stop the cancer cells from growing. The FDA (the U.S. Food and Drug Administration) has not approved IORT for this specific disease but it has been approved for other uses.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of California, Irvine, Irvine, California, United States
Mayo Clinic, Jacksonville, Jacksonville, Florida, United States
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
Mayo Clinic, Rochester, Rochester, Minnesota, United States
University of North, Carolina Chapel Hill, Chapel Hill, North Carolina, United States
Ohio State University Medical Center, Columbus, Ohio, United States
Name: Theodore S. Hong, MD
Affiliation: Massachusetts General Hospital
Role: PRINCIPAL_INVESTIGATOR