Spots Global Cancer Trial Database for The Neutrophil-to-Lymphocyte Ratio to Exclude Pancreatic Fistula

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Trial Identification

Brief Title: The Neutrophil-to-Lymphocyte Ratio to Exclude Pancreatic Fistula

Official Title: The Neutrophil-to-Lymphocyte Ratio at Post-operative Day 3: a Simple Tool to Exclude Clinically Relevant Postoperative Pancreatic Fistula After Pancreatoduodenectomy

Study ID: NCT04724551

Conditions

Pancreas Neoplasm

Interventions

pancreatoduodenectomy (PD)

Study Description

Brief Summary: There is still no consensus on whether drain fluid amylase (DFA) level, C-reactive protein (CRP) level, or complex scores predict clinically relevant postoperative pancreatic fistula (CR-POPF). The aim of this study is to determine the accuracy of simple biochemical parameters (leucocytes, neutrophils, lymphocytes, Neutrophil to Lymphocytes Ratio (NLR), at postoperative days 1 and 3) to exclude the diagnosis of CR-POPF.

Detailed Description: From January 1, 2012 to December 31, 2020, consecutive patients underwent PD performed at Institut Paoli-Calmettes for various pathologies. Data were entered prospectively into a clinical database (NCT02871336). The cohort was split into 3 groups: * a training cohort ; * an internal validation cohort (Paoli Calmettes institute); * an external validation cohort (Rennes Pontchaillou Hospital).