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Brief Title: Selumetinib and Akt Inhibitor MK2206 or mFOLFOX Therapy Comprising Oxaliplatin and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer Previously Treated With Chemotherapy
Official Title: Randomized Phase II Clinical Trial of AZD6244 Hydrogen Sulfate (NSC-748727) and MK-2206 (NSC-749607) vs mFOLFOX in Patients With Metastatic Pancreatic Cancer After Prior Chemotherapy
Study ID: NCT01658943
Brief Summary: This randomized phase II trial studies how well selumetinib and Akt inhibitor MK2206 work compared to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) therapy in treating patients with metastatic pancreatic cancer previously treated with chemotherapy. Selumetinib and Akt inhibitor MK2206 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as oxaliplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet know whether selumetinib and Akt inhibitor MK2206 are more effective than oxaliplatin and fluorouracil in treating patients with metastatic pancreatic cancer.
Detailed Description: PRIMARY OBJECTIVES: I. To assess overall survival in patients with metastatic pancreatic cancer treated with the combination of AZD6244 hydrogen sulfate (selumetinib) and MK-2206 (Akt inhibitor MK2206) compared to those treated with mFOLFOX. SECONDARY OBJECTIVES: I. To assess the frequency and severity of toxicity associated with the combination of AZD6244 hydrogen sulfate and MK-2206 compared to those with mFOLFOX in this patient population. TERTIARY OBJECTIVES: I. To assess progression free survival (PFS) in patients with metastatic pancreatic cancer treated with the combination of AZD6244 hydrogen sulfate and MK-2206 compared to those treated with mFOLFOX. II. To assess objective tumor response in the subset of patients with measurable disease (confirmed and unconfirmed complete and partial response) in patients with metastatic pancreatic cancer treated with the combination of AZD6244 hydrogen sulfate and MK-2206 compared to those treated with mFOLFOX. III. To bank tissue and blood for future translational medicine studies. OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM I: Patients receive oxaliplatin intravenously (IV) over 2 hours on days 1 and 15 and fluorouracil IV over 46-48 hours on days 1-2 and 15-16 (mFOLFOX). ARM II: Patients receive Akt inhibitor MK2206 orally (PO) on days 1, 8, 15, and 22, and selumetinib PO daily on days 1-28. In all arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 6 months for up to 3 years.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
The University of Arizona Cancer Center-Orange Grove Campus, Tucson, Arizona, United States
The University of Arizona Cancer Center-North Campus, Tucson, Arizona, United States
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Kaiser Permanente-Anaheim, Anaheim, California, United States
Kaiser Permanente-Deer Valley Medical Center, Antioch, California, United States
Kaiser Permanente-Baldwin Park, Baldwin Park, California, United States
Kaiser Permanente-Bellflower, Bellflower, California, United States
Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California, United States
Mills - Peninsula Hospitals, Burlingame, California, United States
East Bay Radiation Oncology Center, Castro Valley, California, United States
Valley Medical Oncology Consultants-Castro Valley, Castro Valley, California, United States
City of Hope Comprehensive Cancer Center, Duarte, California, United States
Epic Care-Dublin, Dublin, California, United States
Bay Area Breast Surgeons Inc, Emeryville, California, United States
Epic Care Partners in Cancer Care, Emeryville, California, United States
Kaiser Permanente Hospital, Fontana, California, United States
Kaiser Permanente-Fremont, Fremont, California, United States
Valley Medical Oncology Consultants-Fremont, Fremont, California, United States
Kaiser Permanente, Fresno, California, United States
Saint Jude Medical Center, Fullerton, California, United States
Kaiser Permanente - Harbor City, Harbor City, California, United States
Kaiser Permanente-Irvine, Irvine, California, United States
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, United States
Los Angeles County-USC Medical Center, Los Angeles, California, United States
USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States
Kaiser Permanente-Cadillac, Los Angeles, California, United States
Cedars-Sinai Medical Center, Los Angeles, California, United States
Contra Costa Regional Medical Center, Martinez, California, United States
Fremont - Rideout Cancer Center, Marysville, California, United States
Mercy UC Davis Cancer Center, Merced, California, United States
Kaiser Permanente-Modesto, Modesto, California, United States
El Camino Hospital, Mountain View, California, United States
Sutter Cancer Research Consortium, Novato, California, United States
Highland General Hospital, Oakland, California, United States
Alta Bates Summit Medical Center - Summit Campus, Oakland, California, United States
Bay Area Tumor Institute, Oakland, California, United States
Hematology and Oncology Associates-Oakland, Oakland, California, United States
Tom K Lee Inc, Oakland, California, United States
Kaiser Permanente-Oakland, Oakland, California, United States
Saint Joseph Hospital - Orange, Orange, California, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, United States
Kaiser Permanente - Panorama City, Panorama City, California, United States
East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill, Pleasant Hill, California, United States
Valley Medical Oncology Consultants, Pleasanton, California, United States
Kaiser Permanente-Redwood City, Redwood City, California, United States
Kaiser Permanente-Richmond, Richmond, California, United States
Kaiser Permanente-Riverside, Riverside, California, United States
Kaiser Permanente-Roseville, Roseville, California, United States
University of California Davis Comprehensive Cancer Center, Sacramento, California, United States
Kaiser Permanente-South Sacramento, Sacramento, California, United States
Kaiser Permanente - Sacramento, Sacramento, California, United States
Saint Helena Hospital, Saint Helena, California, United States
Kaiser Permanente-San Diego Mission, San Diego, California, United States
Kaiser Permanente-San Diego Zion, San Diego, California, United States
Kaiser Permanente-San Francisco, San Francisco, California, United States
California Pacific Medical Center-Pacific Campus, San Francisco, California, United States
Kaiser Permanente-Santa Teresa-San Jose, San Jose, California, United States
Kaiser Permanente San Leandro, San Leandro, California, United States
Kaiser Permanente-San Marcos, San Marcos, California, United States
Doctors Medical Center- JC Robinson Regional Cancer Center, San Pablo, California, United States
Kaiser Permanente-San Rafael, San Rafael, California, United States
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California, United States
Kaiser Permanente-Santa Rosa, Santa Rosa, California, United States
Sutter Pacific Medical Foundation, Santa Rosa, California, United States
Kaiser Permanente-South San Francisco, South San Francisco, California, United States
Kaiser Permanente-Stockton, Stockton, California, United States
Tahoe Forest Cancer Center, Truckee, California, United States
Kaiser Permanente Medical Center-Vacaville, Vacaville, California, United States
Kaiser Permanente-Vallejo, Vallejo, California, United States
Sutter Solano Medical Center/Cancer Center, Vallejo, California, United States
Kaiser Permanente-Walnut Creek, Walnut Creek, California, United States
Kaiser Permanente, Woodland Hills, California, United States
The Medical Center of Aurora, Aurora, Colorado, United States
Boulder Community Hospital, Boulder, Colorado, United States
Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado, United States
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado, United States
Rocky Mountain Cancer Centers-Penrose, Colorado Springs, Colorado, United States
Kaiser Permanente-Franklin, Denver, Colorado, United States
Porter Adventist Hospital, Denver, Colorado, United States
Colorado Blood Cancer Institute, Denver, Colorado, United States
Exempla Saint Joseph Hospital, Denver, Colorado, United States
Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado, United States
Rocky Mountain Cancer Centers-Midtown, Denver, Colorado, United States
Rocky Mountain Cancer Centers-Rose, Denver, Colorado, United States
Rose Medical Center, Denver, Colorado, United States
Colorado Cancer Research Program CCOP, Denver, Colorado, United States
Mercy Medical Center, Durango, Colorado, United States
Comprehensive Cancer Care and Research Institute of Colorado LLC, Englewood, Colorado, United States
Swedish Medical Center, Englewood, Colorado, United States
Poudre Valley Hospital, Fort Collins, Colorado, United States
Front Range Cancer Specialists, Fort Collins, Colorado, United States
Mountain Blue Cancer Care Center, Golden, Colorado, United States
North Colorado Medical Center, Greeley, Colorado, United States
Rocky Mountain Cancer Centers-Greenwood Village, Greenwood Village, Colorado, United States
Kaiser Permanente-Rock Creek, Lafayette, Colorado, United States
Rocky Mountain Cancer Centers-Lakewood, Lakewood, Colorado, United States
Saint Anthony Hospital, Lakewood, Colorado, United States
Littleton Adventist Hospital, Littleton, Colorado, United States
Kaiser Permanente-Lone Tree, Lone Tree, Colorado, United States
Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree, Colorado, United States
Sky Ridge Medical Center, Lone Tree, Colorado, United States
Longmont United Hospital, Longmont, Colorado, United States
Rocky Mountain Cancer Centers-Longmont, Longmont, Colorado, United States
McKee Medical Center, Loveland, Colorado, United States
Parker Adventist Hospital, Parker, Colorado, United States
Rocky Mountain Cancer Centers-Parker, Parker, Colorado, United States
Saint Mary Corwin Medical Center, Pueblo, Colorado, United States
Rocky Mountain Cancer Centers - Pueblo, Pueblo, Colorado, United States
SCL Health Lutheran Medical Center, Wheat Ridge, Colorado, United States
Saint Francis Hospital and Medical Center, Hartford, Connecticut, United States
Middlesex Hospital, Middletown, Connecticut, United States
Stamford Hospital/Bennett Cancer Center, Stamford, Connecticut, United States
Beebe Medical Center, Lewes, Delaware, United States
Christiana Gynecologic Oncology LLC, Newark, Delaware, United States
Delaware Clinical and Laboratory Physicians PA, Newark, Delaware, United States
Helen F Graham Cancer Center, Newark, Delaware, United States
Medical Oncology Hematology Consultants PA, Newark, Delaware, United States
Regional Hematology and Oncology PA, Newark, Delaware, United States
Christiana Care Health System-Christiana Hospital, Newark, Delaware, United States
Beebe Health Campus, Rehoboth Beach, Delaware, United States
Nanticoke Memorial Hospital, Seaford, Delaware, United States
Christiana Care Health System-Wilmington Hospital, Wilmington, Delaware, United States
Baptist Cancer Institute, Jacksonville, Florida, United States
Florida Hospital Orlando, Orlando, Florida, United States
University Cancer and Blood Center LLC, Athens, Georgia, United States
Georgia Regents University Medical Center, Augusta, Georgia, United States
Dekalb Medical Center, Decatur, Georgia, United States
Northeast Georgia Medical Center, Gainesville, Georgia, United States
Medical Center of Central Georgia, Macon, Georgia, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia, United States
South Georgia Medical Center, Valdosta, Georgia, United States
Oncare Hawaii Inc-Pali Momi, Aiea, Hawaii, United States
Pali Momi Medical Center, Aiea, Hawaii, United States
Oncare Hawaii Inc-POB II, Honolulu, Hawaii, United States
Queen's Medical Center, Honolulu, Hawaii, United States
Straub Clinic and Hospital, Honolulu, Hawaii, United States
University of Hawaii Cancer Center, Honolulu, Hawaii, United States
OnCare Hawaii-Liliha, Honolulu, Hawaii, United States
Oncare Hawaii Inc-Kuakini, Honolulu, Hawaii, United States
Kaiser Permanente Moanalua Medical Center, Honolulu, Hawaii, United States
Castle Medical Center, Kailua, Hawaii, United States
Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii, United States
Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States
Idaho Urologic Institute-Meridian, Meridian, Idaho, United States
Kootenai Cancer Center, Post Falls, Idaho, United States
Rush - Copley Medical Center, Aurora, Illinois, United States
Memorial Hospital of Carbondale, Carbondale, Illinois, United States
Centralia Oncology Clinic, Centralia, Illinois, United States
Northwestern University, Chicago, Illinois, United States
Rush University Medical Center, Chicago, Illinois, United States
University of Illinois, Chicago, Illinois, United States
University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States
Weiss Memorial Hospital, Chicago, Illinois, United States
Cancer Care Center of Decatur, Decatur, Illinois, United States
Central Illinois CCOP, Decatur, Illinois, United States
Decatur Memorial Hospital, Decatur, Illinois, United States
Crossroads Cancer Center, Effingham, Illinois, United States
Advocate Sherman Hospital, Elgin, Illinois, United States
Ingalls Memorial Hospital, Harvey, Illinois, United States
Hematology Oncology Associates of Illinois-Highland Park, Highland Park, Illinois, United States
Joliet Oncology-Hematology Associates Limited, Joliet, Illinois, United States
Presence Saint Mary's Hospital, Kankakee, Illinois, United States
NorthShore Hematology Oncology-Libertyville, Libertyville, Illinois, United States
Loyola University Medical Center, Maywood, Illinois, United States
Good Samaritan Regional Health Center, Mount Vernon, Illinois, United States
Illinois Cancer Specialists-Niles, Niles, Illinois, United States
West Suburban Medical Center, River Forest, Illinois, United States
Hematology Oncology Associates of Illinois - Skokie, Skokie, Illinois, United States
Memorial Medical Center, Springfield, Illinois, United States
Carle Cancer Center, Urbana, Illinois, United States
Franciscan St. Francis Health-Beech Grove, Beech Grove, Indiana, United States
Elkhart Clinic, Elkhart, Indiana, United States
Michiana Hematology Oncology PC-Elkhart, Elkhart, Indiana, United States
Elkhart General Hospital, Elkhart, Indiana, United States
Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne, Indiana, United States
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States
IU Health Central Indiana Cancer Centers-East, Indianapolis, Indiana, United States
Franciscan Saint Francis Health-Indianapolis, Indianapolis, Indiana, United States
Community Howard Regional Health, Kokomo, Indiana, United States
IU Health La Porte Hospital, La Porte, Indiana, United States
Franciscan Saint Anthony Health-Michigan City, Michigan City, Indiana, United States
Cancer Care Partners LLC, Mishawaka, Indiana, United States
Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana, United States
Saint Joseph Regional Medical Center-Mishawaka, Mishawaka, Indiana, United States
Michiana Hematology Oncology PC-Plymouth, Plymouth, Indiana, United States
Reid Hospital and Health Care Services, Richmond, Indiana, United States
Memorial Hospital of South Bend, South Bend, Indiana, United States
Michiana Hematology Oncology PC-South Bend, South Bend, Indiana, United States
South Bend Clinic, South Bend, Indiana, United States
Northern Indiana Cancer Research Consortium CCOP, South Bend, Indiana, United States
Michiana Hematology Oncology PC-Westville, Westville, Indiana, United States
Hematology Oncology Associates-Quad Cities, Bettendorf, Iowa, United States
Genesis Medical Center - East Campus, Davenport, Iowa, United States
Siouxland Regional Cancer Center, Sioux City, Iowa, United States
Mercy Medical Center-Sioux City, Sioux City, Iowa, United States
Saint Luke's Regional Medical Center, Sioux City, Iowa, United States
Cancer Center of Kansas - Chanute, Chanute, Kansas, United States
Cancer Center of Kansas - Dodge City, Dodge City, Kansas, United States
Cancer Center of Kansas - El Dorado, El Dorado, Kansas, United States
Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas, United States
Cancer Center of Kansas-Independence, Independence, Kansas, United States
Providence Medical Center, Kansas City, Kansas, United States
Cancer Center of Kansas-Kingman, Kingman, Kansas, United States
Lawrence Memorial Hospital, Lawrence, Kansas, United States
Cancer Center of Kansas-Liberal, Liberal, Kansas, United States
Cancer Center of Kansas-Manhattan, Manhattan, Kansas, United States
Cancer Center of Kansas - McPherson, McPherson, Kansas, United States
Cancer Center of Kansas - Newton, Newton, Kansas, United States
Menorah Medical Center, Overland Park, Kansas, United States
Saint Luke's South Hospital, Overland Park, Kansas, United States
Cancer Center of Kansas - Parsons, Parsons, Kansas, United States
Kansas City CCOP, Prairie Village, Kansas, United States
Cancer Center of Kansas - Pratt, Pratt, Kansas, United States
Cancer Center of Kansas - Salina, Salina, Kansas, United States
Cancer Center of Kansas - Wellington, Wellington, Kansas, United States
Associates In Womens Health, Wichita, Kansas, United States
Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita, Kansas, United States
Cancer Center of Kansas - Main Office, Wichita, Kansas, United States
Via Christi Regional Medical Center, Wichita, Kansas, United States
Wichita CCOP, Wichita, Kansas, United States
Cancer Center of Kansas - Winfield, Winfield, Kansas, United States
Oncology Hematology Care Inc-Crestview, Crestview Hills, Kentucky, United States
Hematology/Oncology Clinic LLP, Baton Rouge, Louisiana, United States
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, United States
Ochsner Health Center-Summa, Baton Rouge, Louisiana, United States
Cancer Center of Acadiana, Lafayette, Louisiana, United States
DeSoto Regional Health System, Mansfield, Louisiana, United States
University Health-Conway, Monroe, Louisiana, United States
Louisiana State University Health Science Center, New Orleans, Louisiana, United States
Tulane University Health Sciences Center, New Orleans, Louisiana, United States
Ochsner Baptist Medical Center, New Orleans, Louisiana, United States
Ochsner Medical Center Jefferson, New Orleans, Louisiana, United States
Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, United States
Highland Clinic, Shreveport, Louisiana, United States
Harold Alfond Center for Cancer Care, Augusta, Maine, United States
Eastern Maine Medical Center, Bangor, Maine, United States
Union Hospital of Cecil County, Elkton MD, Maryland, United States
Bixby Medical Center, Adrian, Michigan, United States
Hickman Cancer Center, Adrian, Michigan, United States
Saint Joseph Mercy Hospital, Ann Arbor, Michigan, United States
Michigan Cancer Research Consortium CCOP, Ann Arbor, Michigan, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Bronson Battle Creek, Battle Creek, Michigan, United States
Spectrum Health Big Rapids Hospital, Big Rapids, Michigan, United States
Huron Valley-Sinai Hospital, Commerce, Michigan, United States
Oakwood Hospital and Medical Center, Dearborn, Michigan, United States
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, United States
Saint John Hospital and Medical Center, Detroit, Michigan, United States
Hurley Medical Center, Flint, Michigan, United States
Genesys Hurley Cancer Institute, Flint, Michigan, United States
Genesys Regional Medical Center, Grand Blanc, Michigan, United States
Grand Rapids Clinical Oncology Program, Grand Rapids, Michigan, United States
Mercy Health Saint Mary's, Grand Rapids, Michigan, United States
Spectrum Health at Butterworth Campus, Grand Rapids, Michigan, United States
Allegiance Health, Jackson, Michigan, United States
Borgess Medical Center, Kalamazoo, Michigan, United States
Bronson Methodist Hospital, Kalamazoo, Michigan, United States
West Michigan Cancer Center, Kalamazoo, Michigan, United States
Sparrow Hospital, Lansing, Michigan, United States
Saint Mary Mercy Hospital, Livonia, Michigan, United States
Mercy Memorial Hospital, Monroe, Michigan, United States
Toledo Clinic Cancer Centers-Monroe, Monroe, Michigan, United States
Mercy Health Mercy Campus, Muskegon, Michigan, United States
Saint Joseph Mercy Oakland, Pontiac, Michigan, United States
Saint Joseph Mercy Port Huron, Port Huron, Michigan, United States
Spectrum Health Reed City Hospital, Reed City, Michigan, United States
Saint Mary's of Michigan, Saginaw, Michigan, United States
Marie Yeager Cancer Center, Saint Joseph, Michigan, United States
Providence Hospital-Southfield Cancer Center, Southfield, Michigan, United States
Lakeland Hospital, St. Joseph, Michigan, United States
Munson Medical Center, Traverse City, Michigan, United States
Saint John Macomb-Oakland Hospital, Warren, Michigan, United States
Sanford Clinic North-Bemidgi, Bemidji, Minnesota, United States
Fairview Ridges Hospital, Burnsville, Minnesota, United States
Mercy Hospital, Coon Rapids, Minnesota, United States
Fairview-Southdale Hospital, Edina, Minnesota, United States
Unity Hospital, Fridley, Minnesota, United States
Hutchinson Area Health Care, Hutchinson, Minnesota, United States
Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota, United States
Saint John's Hospital - Healtheast, Maplewood, Minnesota, United States
Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States
Hennepin County Medical Center, Minneapolis, Minnesota, United States
New Ulm Medical Center, New Ulm, Minnesota, United States
North Memorial Medical Health Center, Robbinsdale, Minnesota, United States
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota, United States
Saint Cloud Hospital, Saint Cloud, Minnesota, United States
Metro Minnesota Community Oncology Research Consortium, Saint Louis Park, Minnesota, United States
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota, United States
Regions Hospital, Saint Paul, Minnesota, United States
United Hospital, Saint Paul, Minnesota, United States
Saint Francis Regional Medical Center, Shakopee, Minnesota, United States
Lakeview Hospital, Stillwater, Minnesota, United States
Ridgeview Medical Center, Waconia, Minnesota, United States
Rice Memorial Hospital, Willmar, Minnesota, United States
Minnesota Oncology and Hematology PA-Woodbury, Woodbury, Minnesota, United States
University of Mississippi Medical Center, Jackson, Mississippi, United States
Saint Francis Medical Center, Cape Girardeau, Missouri, United States
Southeast Cancer Center, Cape Girardeau, Missouri, United States
University of Missouri - Ellis Fischel, Columbia, Missouri, United States
Centerpoint Medical Center LLC, Independence, Missouri, United States
Capital Region Medical Center-Goldschmidt Cancer Center, Jefferson City, Missouri, United States
Saint Luke's Hospital of Kansas City, Kansas City, Missouri, United States
North Kansas City Hospital, Kansas City, Missouri, United States
Heartland Hematology and Oncology Associates Incorporated, Kansas City, Missouri, United States
Kansas City Veterans Affairs Medical Center, Kansas City, Missouri, United States
Research Medical Center, Kansas City, Missouri, United States
Saint Luke's East - Lee's Summit, Lee's Summit, Missouri, United States
Liberty Radiation Oncology Center, Liberty, Missouri, United States
Phelps County Regional Medical Center, Rolla, Missouri, United States
Saint John's Clinic-Rolla-Cancer and Hematology, Rolla, Missouri, United States
Heartland Regional Medical Center, Saint Joseph, Missouri, United States
Saint Joseph Oncology Inc, Saint Joseph, Missouri, United States
Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Missouri Baptist Medical Center, Saint Louis, Missouri, United States
Mercy Hospital Saint Louis, Saint Louis, Missouri, United States
Cancer Research for the Ozarks NCORP, Springfield, Missouri, United States
Mercy Hospital Springfield, Springfield, Missouri, United States
CoxHealth South Hospital, Springfield, Missouri, United States
Montana Cancer Consortium NCORP, Billings, Montana, United States
Saint Vincent Healthcare, Billings, Montana, United States
Frontier Cancer Center and Blood Institute-Billings, Billings, Montana, United States
Billings Clinic Cancer Center, Billings, Montana, United States
Bozeman Deaconess Hospital, Bozeman, Montana, United States
Saint James Community Hospital and Cancer Treatment Center, Butte, Montana, United States
Benefis Healthcare- Sletten Cancer Institute, Great Falls, Montana, United States
Big Sky Oncology, Great Falls, Montana, United States
Saint Peter's Community Hospital, Helena, Montana, United States
Kalispell Medical Oncology, Kalispell, Montana, United States
Kalispell Regional Medical Center, Kalispell, Montana, United States
Montana Cancer Specialists, Missoula, Montana, United States
Saint Patrick Hospital - Community Hospital, Missoula, Montana, United States
CHI Health Good Samaritan, Kearney, Nebraska, United States
Nebraska Cancer Research Center, Lincoln, Nebraska, United States
Missouri Valley Cancer Consortium, Omaha, Nebraska, United States
Alegent Health Immanuel Medical Center, Omaha, Nebraska, United States
Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska, United States
Alegent Health Lakeside Hospital, Omaha, Nebraska, United States
Creighton University Medical Center, Omaha, Nebraska, United States
University Medical Center of Southern Nevada, Las Vegas, Nevada, United States
Nevada Cancer Research Foundation CCOP, Las Vegas, Nevada, United States
Cooper Hospital University Medical Center, Camden, New Jersey, United States
Veterans Adminstration New Jersey Health Care System, East Orange, New Jersey, United States
AtlantiCare Surgery Center, Egg Harbor Township, New Jersey, United States
Englewood Hospital and Medical Center, Englewood, New Jersey, United States
UMDNJ - New Jersey Medical School, Newark, New Jersey, United States
Albert Einstein College of Medicine, Bronx, New York, United States
Montefiore Medical Center - Moses Campus, Bronx, New York, United States
Kings County Hospital, Brooklyn, New York, United States
State University of New York Downstate Medical Center, Brooklyn, New York, United States
Mary Imogene Bassett Hospital, Cooperstown, New York, United States
Glens Falls Hospital, Glens Falls, New York, United States
Orange Regional Medical Center, Middletown, New York, United States
Winthrop University Hospital, Mineola, New York, United States
Columbia University Medical Center, New York, New York, United States
University of Rochester, Rochester, New York, United States
Staten Island University Hospital, Staten Island, New York, United States
Randolph Hospital, Asheboro, North Carolina, United States
Wayne Memorial Hospital, Goldsboro, North Carolina, United States
Cone Health Cancer Center, Greensboro, North Carolina, United States
Kinston Medical Specialists PA, Kinston, North Carolina, United States
FirstHealth of the Carolinas-Moore Regional Hosiptal, Pinehurst, North Carolina, United States
Annie Penn Memorial Hospital, Reidsville, North Carolina, United States
Iredell Memorial Hospital, Statesville, North Carolina, United States
Southeast Cancer Control Consortium CCOP, Winston-Salem, North Carolina, United States
Mid Dakota Clinic, Bismarck, North Dakota, United States
Saint Alexius Medical Center, Bismarck, North Dakota, United States
Sanford Bismarck Medical Center, Bismarck, North Dakota, United States
Roger Maris Cancer Center, Fargo, North Dakota, United States
Sanford Clinic North-Fargo, Fargo, North Dakota, United States
Sanford Medical Center-Fargo, Fargo, North Dakota, United States
Summa Akron City Hospital/Cooper Cancer Center, Akron, Ohio, United States
Akron General Medical Center, Akron, Ohio, United States
Summa Barberton Hospital, Barberton, Ohio, United States
Cleveland Clinic Cancer Center Beachwood, Beachwood, Ohio, United States
Strecker Cancer Center-Belpre, Belpre, Ohio, United States
Toledo Clinic Cancer Centers-Bowling Green, Bowling Green, Ohio, United States
Adena Regional Medical Center, Chillicothe, Ohio, United States
Oncology Hematology Care Inc-Eden Park, Cincinnati, Ohio, United States
Oncology Hematology Care Inc-Mercy West, Cincinnati, Ohio, United States
Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio, United States
Oncology Hematology Care Inc - Anderson, Cincinnati, Ohio, United States
Oncology Hematology Care Inc - Kenwood, Cincinnati, Ohio, United States
Bethesda North Hospital, Cincinnati, Ohio, United States
Oncology Hematology Care Inc-Blue Ash, Cincinnati, Ohio, United States
Case Western Reserve University, Cleveland, Ohio, United States
MetroHealth Medical Center, Cleveland, Ohio, United States
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio, United States
Cleveland Clinic Foundation, Cleveland, Ohio, United States
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
Columbus Oncology and Hematology Associates Inc, Columbus, Ohio, United States
Riverside Methodist Hospital, Columbus, Ohio, United States
Columbus CCOP, Columbus, Ohio, United States
Grant Medical Center, Columbus, Ohio, United States
The Mark H Zangmeister Center, Columbus, Ohio, United States
Mount Carmel Health Center West, Columbus, Ohio, United States
Doctors Hospital, Columbus, Ohio, United States
Grandview Hospital, Dayton, Ohio, United States
Good Samaritan Hospital - Dayton, Dayton, Ohio, United States
Miami Valley Hospital, Dayton, Ohio, United States
Samaritan North Health Center, Dayton, Ohio, United States
Dayton CCOP, Dayton, Ohio, United States
Delaware Health Center-Grady Cancer Center, Delaware, Ohio, United States
Delaware Radiation Oncology, Delaware, Ohio, United States
Grady Memorial Hospital, Delaware, Ohio, United States
Hematology Oncology Center Incorporated, Elyria, Ohio, United States
Mercy Cancer Center-Elyria, Elyria, Ohio, United States
Oncology Hematology Care Inc-Healthplex, Fairfield, Ohio, United States
Blanchard Valley Hospital, Findlay, Ohio, United States
Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States
Wayne Hospital, Greenville, Ohio, United States
Kettering Medical Center, Kettering, Ohio, United States
Fairfield Medical Center, Lancaster, Ohio, United States
Lancaster Radiation Oncology, Lancaster, Ohio, United States
Saint Rita's Medical Center, Lima, Ohio, United States
Lima Memorial Hospital, Lima, Ohio, United States
Marietta Memorial Hospital, Marietta, Ohio, United States
Toledo Clinic Cancer Centers-Maumee, Maumee, Ohio, United States
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center, Maumee, Ohio, United States
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio, United States
Knox Community Hospital, Mount Vernon, Ohio, United States
Licking Memorial Hospital, Newark, Ohio, United States
Newark Radiation Oncology, Newark, Ohio, United States
Saint Charles Hospital, Oregon, Ohio, United States
Toledo Clinic Cancer Centers-Oregon, Oregon, Ohio, United States
Southern Ohio Medical Center, Portsmouth, Ohio, United States
North Coast Cancer Care, Sandusky, Ohio, United States
Springfield Regional Medical Center, Springfield, Ohio, United States
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio, United States
Flower Hospital, Sylvania, Ohio, United States
Mercy Hospital of Tiffin, Tiffin, Ohio, United States
The Toledo Hospital/Toledo Children's Hospital, Toledo, Ohio, United States
Saint Vincent Mercy Medical Center, Toledo, Ohio, United States
University of Toledo, Toledo, Ohio, United States
Toledo Community Hospital Oncology Program CCOP, Toledo, Ohio, United States
Mercy Saint Anne Hospital, Toledo, Ohio, United States
Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio, United States
Upper Valley Medical Center, Troy, Ohio, United States
Fulton County Health Center, Wauseon, Ohio, United States
Saint Ann's Hospital, Westerville, Ohio, United States
Cleveland Clinic Wooster Specialty Center, Wooster, Ohio, United States
Greene Memorial Hospital, Xenia, Ohio, United States
Genesis HealthCare System, Zanesville, Ohio, United States
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
Oklahoma Oncology Inc, Tulsa, Oklahoma, United States
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma, United States
Warren Cancer Research Foundation, Tulsa, Oklahoma, United States
Tulsa Cancer Institute, Tulsa, Oklahoma, United States
Legacy Mount Hood Medical Center, Gresham, Oregon, United States
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon, United States
Legacy Emanuel Hospital and Health Center, Portland, Oregon, United States
Legacy Meridian Park Hospital, Tualatin, Oregon, United States
Abington Memorial Hospital, Abington, Pennsylvania, United States
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, United States
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania, United States
Bryn Mawr Hospital, Bryn Mawr, Pennsylvania, United States
Geisinger Medical Center, Danville, Pennsylvania, United States
Geisinger Medical Center-Cancer Center Hazleton, Hazleton, Pennsylvania, United States
Lancaster General Hospital, Lancaster, Pennsylvania, United States
Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania, United States
Paoli Memorial Hospital, Paoli, Pennsylvania, United States
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania, United States
Geisinger Medical Oncology-Pottsville, Pottsville, Pennsylvania, United States
Guthrie Medical Group PC-Robert Packer Hospital, Sayre, Pennsylvania, United States
Geisinger Medical Group, State College, Pennsylvania, United States
Reading Hospital, West Reading, Pennsylvania, United States
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania, United States
Lankenau Medical Center, Wynnewood, Pennsylvania, United States
Mainline Health CCOP, Wynnewood, Pennsylvania, United States
Sanford Cancer Center-Oncology Clinic, Sioux Falls, South Dakota, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States
Erlanger Medical Center, Chattanooga, Tennessee, United States
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, United States
The Don and Sybil Harrington Cancer Center, Amarillo, Texas, United States
Texas Tech University Health Sciences Center, Lubbock, Texas, United States
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States
Danville Hematology Oncology, Danville, Virginia, United States
Danville Regional Medical Center, Danville, Virginia, United States
Fredericksburg Oncology Inc, Fredericksburg, Virginia, United States
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States
Cancer Care Center at Island Hospital, Anacortes, Washington, United States
PeaceHealth Saint Joseph Medical Center, Bellingham, Washington, United States
Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton, Washington, United States
Highline Medical Center-Main Campus, Burien, Washington, United States
Swedish Medical Center-Edmonds, Edmonds, Washington, United States
Swedish Cancer Institute-Issaquah, Issaquah, Washington, United States
Kadlec Clinic Hematology and Oncology, Kennewick, Washington, United States
Seattle Cancer Care Alliance at EvergreenHealth, Kirkland, Washington, United States
Skagit Valley Hospital, Mount Vernon, Washington, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington, United States
Harborview Medical Center, Seattle, Washington, United States
Minor and James Medical PLLC, Seattle, Washington, United States
Swedish Medical Center-Ballard Campus, Seattle, Washington, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Group Health Cooperative of Puget Sound Oncology Consortium, Seattle, Washington, United States
Group Health Cooperative-Seattle, Seattle, Washington, United States
Swedish Medical Center-First Hill, Seattle, Washington, United States
University of Washington Medical Center, Seattle, Washington, United States
United General Hospital, Sedro-Woolley, Washington, United States
Cancer Care Northwest - Spokane South, Spokane, Washington, United States
Evergreen Hematology and Oncology PS, Spokane, Washington, United States
Rockwood Clinic, Spokane, Washington, United States
Legacy Salmon Creek Hospital, Vancouver, Washington, United States
Wenatchee Valley Hospital and Clinics, Wenatchee, Washington, United States
West Virginia University Charleston, Charleston, West Virginia, United States
West Virginia University Healthcare, Morgantown, West Virginia, United States
Langlade Hospital and Cancer Center, Antigo, Wisconsin, United States
Marshfield Clinic-Chippewa Center, Chippewa Falls, Wisconsin, United States
Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire, Wisconsin, United States
Sacred Heart Hospital, Eau Claire, Wisconsin, United States
Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States
Marshfield Clinic - Ladysmith Center, Ladysmith, Wisconsin, United States
Dean Hematology and Oncology Clinic, Madison, Wisconsin, United States
Marshfield Clinic, Marshfield, Wisconsin, United States
Saint Joseph's Hospital, Marshfield, Wisconsin, United States
Marshfield Clinic-Minocqua Center, Minocqua, Wisconsin, United States
D N Greenwald Center, Mukwonago, Wisconsin, United States
Cancer Center of Western Wisconsin, New Richmond, Wisconsin, United States
Oconomowoc Memorial Hospital-ProHealth Care Inc, Oconomowoc, Wisconsin, United States
Marshfield Clinic at James Beck Cancer Center, Rhinelander, Wisconsin, United States
Saint Mary's Hospital, Rhinelander, Wisconsin, United States
Marshfield Clinic-Rice Lake Center, Rice Lake, Wisconsin, United States
Marshfield Clinic Cancer Care at Saint Michael's Hospital, Stevens Point, Wisconsin, United States
Saint Michael's Hospital, Stevens Point, Wisconsin, United States
Waukesha Memorial Hospital, Waukesha, Wisconsin, United States
Aspirus Regional Cancer Center, Wausau, Wisconsin, United States
Marshfield Clinic-Wausau Center, Wausau, Wisconsin, United States
Diagnostic and Treatment Center, Weston, Wisconsin, United States
Marshfield Clinic - Weston Center, Weston, Wisconsin, United States
Saint Clare's Hospital, Weston, Wisconsin, United States
Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids, Wisconsin, United States
Rocky Mountain Oncology, Casper, Wyoming, United States
Welch Cancer Center, Sheridan, Wyoming, United States
Name: Vincent Chung
Affiliation: SWOG Cancer Research Network
Role: PRINCIPAL_INVESTIGATOR