Spots Global Cancer Trial Database for Scheduling Nab-paclitaxel With Gemcitabine
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Trial Identification
Brief Title: Scheduling Nab-paclitaxel With Gemcitabine
Official Title: Randomised Phase II Trial to Investigate Two Different Schedules of Nab-paclitaxel (Abraxane) Combined With Gemcitabine as First Line Treatment for Metastatic Pancreatic Ductal Adenocarcinoma
Study ID: NCT03529175
Conditions
Study Description
Brief Summary: Metastatic pancreatic cancer is difficult to treat. Until recently, most patients would be offered treatment with a chemotherapy drug called gemcitabine. However, a large international trial showed that combining gemcitabine with a drug called nab-paclitaxel (or abraxane) was more effective compared with gemcitabine alone. The purpose of this study is to compare two different ways of combining gemcitabine with abraxane. Conventionally, both drugs are given on the same day via a drip into a vein in the arm but research suggests that giving abraxane 24 hours in advance of gemcitabine could possibly be more beneficial. In this study, blood and tumour samples will be collected and analysed to try to confirm what has been seen in the laboratory studies. In addition, the investigators wish to find out whether certain tumour characteristics (called biomarkers) can be used to predict for response to chemotherapy.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom
Peterborough City Hospital, Peterborough, Cambridgeshire, United Kingdom
Ysbyty Gwynedd, Bangor, , United Kingdom
Belfast City Hospital, Belfast, , United Kingdom
Queen Elizabeth Hospital, Birmingham, , United Kingdom
Bristol Haematology & Oncology Centre, Bristol, , United Kingdom
Velindre Cancer Centre, Cardiff, , United Kingdom
Colchester Hospital, Colchester, , United Kingdom
University Hospitals Coventry & Warwickshire, Coventry, , United Kingdom
Edinburgh Cancer Research Centre, Edinburgh, , United Kingdom
The Beatson Oncology Centre, Glasgow, , United Kingdom
The Royal Surrey County Hospital, Guildford, , United Kingdom
St James' Institute of Oncology, Leeds, , United Kingdom
Leicester Royal Infirmary, Leicester, , United Kingdom
Clatterbridge Cancer Centre, Liverpool, , United Kingdom
Barts Health NHS Trust, London, , United Kingdom
Hammersmith Hospital, London, , United Kingdom
The Royal Free Hospital, London, , United Kingdom
University College London Hospital, London, , United Kingdom
The Christie Hospital, Manchester, , United Kingdom
Churchill Hospital, Oxford, , United Kingdom
Weston Park Hospital, Sheffield, , United Kingdom
Royal Cornwall Hospital, Truro, , United Kingdom
Contact Details
Name: Pippa Corrie
Affiliation: Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital
Role: PRINCIPAL_INVESTIGATOR
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