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Spots Global Cancer Trial Database for Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer

Official Title: A Phase III Trial of Perioperative Versus Adjuvant Chemotherapy for Resectable Pancreatic Cancer

Study ID: NCT04340141

Study Description

Brief Summary: This phase III trial compares perioperative chemotherapy (given before and after surgery) versus adjuvant chemotherapy (given after surgery) for the treatment of pancreatic cancer that can be removed by surgery (removable/resectable). Chemotherapy drugs, such as fluorouracil, irinotecan, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before and after surgery (perioperatively) may work better in treating patients with pancreatic cancer compared to giving chemotherapy after surgery (adjuvantly).

Detailed Description: PRIMARY OBJECTIVES: I. To evaluate and compare overall survival (OS) in patients with resectable pancreatic adenocarcinoma treated with perioperative fluorouracil, irinotecan hydrochloride, leucovorin calcium and oxaliplatin (modified \[m\]FOLFIRINOX) and surgery versus up-front surgery followed by adjuvant mFOLFIRINOX. SECONDARY OBJECTIVES: I. To evaluate and compare disease-free survival (DFS) in patients with resectable pancreatic adenocarcinoma treated with perioperative mFOLFIRINOX and surgery versus up-front surgery followed by adjuvant mFOLFIRINOX. II. To evaluate and compare time to locoregional recurrence (TLR) in patients with resectable pancreatic adenocarcinoma treated with perioperative mFOLFIRINOX and surgery versus up-front surgery followed by adjuvant mFOLFIRINOX. III. To evaluate and compare time to distant metastases (TDM) in patients with resectable pancreatic adenocarcinoma treated with perioperative mFOLFIRINOX and surgery versus up-front surgery followed by adjuvant mFOLFIRINOX. IV. To evaluate and compare the R0 resection rate in patients with resectable pancreatic adenocarcinoma treated with perioperative mFOLFIRINOX and surgery versus up-front surgery followed by adjuvant mFOLFIRINOX. V. To evaluate and compare rate of unresectability in patients with resectable pancreatic adenocarcinoma treated with perioperative mFOLFIRINOX and surgery versus up-front surgery followed by adjuvant mFOLFIRINOX. VI. To evaluate rate of pathologic complete response in patients randomized to the perioperative therapy arm. VII. To evaluate and compare mFOLFIRINOX dose intensity delivered and number of cycles received in patients with resectable pancreatic adenocarcinoma treated with perioperative mFOLFIRINOX and surgery versus up-front surgery followed by adjuvant mFOLFIRINOX. VIII. To evaluate and compare adverse event profile in patients with resectable pancreatic adenocarcinoma treated with perioperative mFOLFIRINOX and surgery versus up-front surgery followed by adjuvant mFOLFIRINOX. IX. To compare physical functioning, nausea/vomiting, and diarrhea, as measured with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30) between patients with resectable pancreatic adenocarcinoma treated with perioperative mFOLFIRINOX and surgery versus up-front surgery followed by adjuvant mFOLFIRINOX. X. To prospectively assess the influence of diet, body mass index, weight loss, physical activity, and other lifestyle habits on the disease-free survival and overall survival among patients with localized pancreatic cancers. XI. To assess the influence of diet, obesity, physical activity, and other lifestyle habits on the risk of toxicity associated with chemotherapy. XII. To evaluate the ability of computed tomography (CT)-based radiomics in distinguishing post-neoadjuvant chemotherapy (NAC) fibrosis from viable tumor in patients randomized to the perioperative therapy arm. XIII. To determine whether CT-based radiomics retrieved from baseline examination may act as non-invasive predictors of survival outcome in patients randomized to the adjuvant therapy arm. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive oxaliplatin intravenously (IV) over 2 hours, irinotecan hydrochloride IV over 90 minutes, and leucovorin calcium over 2 hours on day 1, and fluorouracil IV over 46-48 hours on days 1-3. Treatment repeats every 14 days for 8 cycles in the absence of disease progression or unacceptable toxicity. Within 2-8 weeks of completing neoadjuvant chemotherapy, patients undergo surgical resection. Patients then receive oxaliplatin IV over 2 hours, irinotecan hydrochloride IV over 90 minutes, and leucovorin calcium over 2 hours on day 1, and fluorouracil IV over 46-48 hours on days 1-3. Treatment repeats every 14 days for 4 cycles in the absence of disease progression or unacceptable toxicity. ARM II: Patients undergo surgical resection. Beginning 3-12 weeks after surgery, patients then receive oxaliplatin IV over 2 hours, irinotecan hydrochloride IV over 90 minutes, and leucovorin calcium over 2 hours on day 1, and fluorouracil IV over 46-48 hours on days 1-3. Treatment repeats every 14 days for 12 cycles in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up for 6 years.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States

Thomas Hospital, Fairhope, Alabama, United States

Mobile Infirmary Medical Center, Mobile, Alabama, United States

University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, United States

Anchorage Associates in Radiation Medicine, Anchorage, Alaska, United States

Alaska Breast Care and Surgery LLC, Anchorage, Alaska, United States

Alaska Oncology and Hematology LLC, Anchorage, Alaska, United States

Alaska Women's Cancer Care, Anchorage, Alaska, United States

Anchorage Oncology Centre, Anchorage, Alaska, United States

Katmai Oncology Group, Anchorage, Alaska, United States

Providence Alaska Medical Center, Anchorage, Alaska, United States

Banner University Medical Center - Tucson, Tucson, Arizona, United States

University of Arizona Cancer Center-North Campus, Tucson, Arizona, United States

Mercy Hospital Fort Smith, Fort Smith, Arkansas, United States

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro, Arkansas, United States

University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Kaiser Permanente-Deer Valley Medical Center, Antioch, California, United States

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California, United States

Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California, United States

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California, United States

Mills-Peninsula Medical Center, Burlingame, California, United States

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California, United States

Community Cancer Institute, Clovis, California, United States

Kaiser Permanente Dublin, Dublin, California, United States

Kaiser Permanente-Fremont, Fremont, California, United States

Kaiser Permanente-Fresno, Fresno, California, United States

UC San Diego Moores Cancer Center, La Jolla, California, United States

Los Angeles General Medical Center, Los Angeles, California, United States

USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States

Cedars Sinai Medical Center, Los Angeles, California, United States

Memorial Medical Center, Modesto, California, United States

Kaiser Permanente-Modesto, Modesto, California, United States

Palo Alto Medical Foundation-Camino Division, Mountain View, California, United States

Kaiser Permanente-Oakland, Oakland, California, United States

Saint Joseph Hospital - Orange, Orange, California, United States

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, United States

Palo Alto Medical Foundation Health Care, Palo Alto, California, United States

Stanford Cancer Institute Palo Alto, Palo Alto, California, United States

Kaiser Permanente-Redwood City, Redwood City, California, United States

Kaiser Permanente-Richmond, Richmond, California, United States

Kaiser Permanente-Roseville, Roseville, California, United States

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California, United States

Sutter Roseville Medical Center, Roseville, California, United States

Kaiser Permanente Downtown Commons, Sacramento, California, United States

Sutter Medical Center Sacramento, Sacramento, California, United States

University of California Davis Comprehensive Cancer Center, Sacramento, California, United States

Kaiser Permanente-South Sacramento, Sacramento, California, United States

UC San Diego Medical Center - Hillcrest, San Diego, California, United States

California Pacific Medical Center-Pacific Campus, San Francisco, California, United States

Kaiser Permanente-San Francisco, San Francisco, California, United States

UCSF Medical Center-Mission Bay, San Francisco, California, United States

Kaiser Permanente-Santa Teresa-San Jose, San Jose, California, United States

Kaiser Permanente San Leandro, San Leandro, California, United States

Mills Health Center, San Mateo, California, United States

Kaiser San Rafael-Gallinas, San Rafael, California, United States

Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California, United States

Kaiser Permanente-Santa Rosa, Santa Rosa, California, United States

Kaiser Permanente-South San Francisco, South San Francisco, California, United States

Kaiser Permanente-Stockton, Stockton, California, United States

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California, United States

Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville, California, United States

Kaiser Permanente Medical Center-Vacaville, Vacaville, California, United States

Kaiser Permanente-Vallejo, Vallejo, California, United States

Sutter Solano Medical Center/Cancer Center, Vallejo, California, United States

Kaiser Permanente-Walnut Creek, Walnut Creek, California, United States

Porter Adventist Hospital, Denver, Colorado, United States

Danbury Hospital, Danbury, Connecticut, United States

Smilow Cancer Hospital-Derby Care Center, Derby, Connecticut, United States

Smilow Cancer Hospital Care Center-Fairfield, Fairfield, Connecticut, United States

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury, Connecticut, United States

Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut, United States

Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut, United States

Hartford Hospital, Hartford, Connecticut, United States

Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut, United States

Midstate Medical Center, Meriden, Connecticut, United States

The Hospital of Central Connecticut, New Britain, Connecticut, United States

Yale University, New Haven, Connecticut, United States

Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut, United States

Norwalk Hospital, Norwalk, Connecticut, United States

Smilow Cancer Hospital-Orange Care Center, Orange, Connecticut, United States

Smilow Cancer Hospital-Torrington Care Center, Torrington, Connecticut, United States

Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut, United States

Smilow Cancer Hospital-Waterbury Care Center, Waterbury, Connecticut, United States

Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut, United States

MedStar Georgetown University Hospital, Washington, District of Columbia, United States

Sibley Memorial Hospital, Washington, District of Columbia, United States

AdventHealth Altamonte, Altamonte Springs, Florida, United States

Mount Sinai Comprehensive Cancer Center at Aventura, Aventura, Florida, United States

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida, United States

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida, United States

Regional Cancer Center-Lee Memorial Health System, Fort Myers, Florida, United States

Lakeland Regional Health Hollis Cancer Center, Lakeland, Florida, United States

Mount Sinai Medical Center, Miami Beach, Florida, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida, United States

UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida, United States

AdventHealth Orlando, Orlando, Florida, United States

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida, United States

Cleveland Clinic-Weston, Weston, Florida, United States

Phoebe Putney Memorial Hospital, Albany, Georgia, United States

Augusta University Medical Center, Augusta, Georgia, United States

Northeast Georgia Medical Center-Gainesville, Gainesville, Georgia, United States

Queen's Medical Center, Honolulu, Hawaii, United States

Kaiser Permanente Moanalua Medical Center, Honolulu, Hawaii, United States

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States

Saint Luke's Cancer Institute - Boise, Boise, Idaho, United States

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho, United States

Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho, United States

Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho, United States

Idaho Urologic Institute-Meridian, Meridian, Idaho, United States

Saint Luke's Cancer Institute - Meridian, Meridian, Idaho, United States

Saint Luke's Cancer Institute - Nampa, Nampa, Idaho, United States

Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho, United States

Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho, United States

Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho, United States

Rush - Copley Medical Center, Aurora, Illinois, United States

Illinois CancerCare-Bloomington, Bloomington, Illinois, United States

Illinois CancerCare-Canton, Canton, Illinois, United States

Memorial Hospital of Carbondale, Carbondale, Illinois, United States

SIH Cancer Institute, Carterville, Illinois, United States

Illinois CancerCare-Carthage, Carthage, Illinois, United States

Centralia Oncology Clinic, Centralia, Illinois, United States

Northwestern University, Chicago, Illinois, United States

John H Stroger Jr Hospital of Cook County, Chicago, Illinois, United States

University of Illinois, Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States

Carle at The Riverfront, Danville, Illinois, United States

Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, United States

Decatur Memorial Hospital, Decatur, Illinois, United States

Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois, United States

Carle Physician Group-Effingham, Effingham, Illinois, United States

Crossroads Cancer Center, Effingham, Illinois, United States

Illinois CancerCare-Eureka, Eureka, Illinois, United States

Illinois CancerCare-Galesburg, Galesburg, Illinois, United States

Western Illinois Cancer Treatment Center, Galesburg, Illinois, United States

Northwestern Medicine Cancer Center Delnor, Geneva, Illinois, United States

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois, United States

Illinois CancerCare-Macomb, Macomb, Illinois, United States

Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois, United States

Loyola University Medical Center, Maywood, Illinois, United States

Good Samaritan Regional Health Center, Mount Vernon, Illinois, United States

Cancer Care Center of O'Fallon, O'Fallon, Illinois, United States

Northwestern Medicine Orland Park, Orland Park, Illinois, United States

University of Chicago Medicine-Orland Park, Orland Park, Illinois, United States

Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois, United States

Illinois CancerCare-Pekin, Pekin, Illinois, United States

Illinois CancerCare-Peoria, Peoria, Illinois, United States

Methodist Medical Center of Illinois, Peoria, Illinois, United States

Illinois CancerCare-Peru, Peru, Illinois, United States

Valley Radiation Oncology, Peru, Illinois, United States

Illinois CancerCare-Princeton, Princeton, Illinois, United States

Southern Illinois University School of Medicine, Springfield, Illinois, United States

Springfield Clinic, Springfield, Illinois, United States

Memorial Medical Center, Springfield, Illinois, United States

Carle Cancer Center, Urbana, Illinois, United States

The Carle Foundation Hospital, Urbana, Illinois, United States

Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois, United States

Memorial Hospital of South Bend, South Bend, Indiana, United States

Mary Greeley Medical Center, Ames, Iowa, United States

McFarland Clinic - Ames, Ames, Iowa, United States

Mission Cancer and Blood - Ankeny, Ankeny, Iowa, United States

Iowa Methodist Medical Center, Des Moines, Iowa, United States

Mission Cancer and Blood - Des Moines, Des Moines, Iowa, United States

Broadlawns Medical Center, Des Moines, Iowa, United States

Mercy Medical Center - Des Moines, Des Moines, Iowa, United States

Iowa Lutheran Hospital, Des Moines, Iowa, United States

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa, United States

Methodist West Hospital, West Des Moines, Iowa, United States

Baptist Health Lexington, Lexington, Kentucky, United States

University of Kentucky/Markey Cancer Center, Lexington, Kentucky, United States

The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky, United States

Baptist Health Louisville, Louisville, Kentucky, United States

Baptist Health Madisonville/Merle Mahr Cancer Center, Madisonville, Kentucky, United States

LSU Health Baton Rouge-North Clinic, Baton Rouge, Louisiana, United States

Our Lady of the Lake Physician Group, Baton Rouge, Louisiana, United States

Louisiana Hematology Oncology Associates LLC, Baton Rouge, Louisiana, United States

Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, United States

Medical Center of Baton Rouge, Baton Rouge, Louisiana, United States

Ochsner High Grove, Baton Rouge, Louisiana, United States

Northshore Oncology Associates-Covington, Covington, Louisiana, United States

Ochsner Hematology Oncology North Shore - Covington (West Region), Covington, Louisiana, United States

Terrebonne General Medical Center, Houma, Louisiana, United States

Ochsner Medical Center Kenner, Kenner, Louisiana, United States

University Medical Center New Orleans, New Orleans, Louisiana, United States

Ochsner Medical Center Jefferson, New Orleans, Louisiana, United States

Greater Baltimore Medical Center, Baltimore, Maryland, United States

UM Saint Joseph Medical Center, Towson, Maryland, United States

Tufts Medical Center, Boston, Massachusetts, United States

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States

Boston Medical Center, Boston, Massachusetts, United States

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Hickman Cancer Center, Adrian, Michigan, United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan, United States

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

Trinity Health Medical Center - Brighton, Brighton, Michigan, United States

Trinity Health Medical Center - Canton, Canton, Michigan, United States

Saint Joseph Mercy Chelsea, Chelsea, Michigan, United States

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, United States

Henry Ford Hospital, Detroit, Michigan, United States

Ascension Saint John Hospital, Detroit, Michigan, United States

Weisberg Cancer Treatment Center, Farmington Hills, Michigan, United States

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Ascension Providence Hospitals - Novi, Novi, Michigan, United States

William Beaumont Hospital-Royal Oak, Royal Oak, Michigan, United States

Ascension Saint Mary's Hospital, Saginaw, Michigan, United States

Ascension Providence Hospitals - Southfield, Southfield, Michigan, United States

William Beaumont Hospital - Troy, Troy, Michigan, United States

Saint John Macomb-Oakland Hospital, Warren, Michigan, United States

Baptist Cancer Center-Grenada, Grenada, Mississippi, United States

Baptist Memorial Hospital and Cancer Center-Union County, New Albany, Mississippi, United States

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford, Mississippi, United States

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven, Mississippi, United States

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin, Missouri, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

Southeast Cancer Center, Cape Girardeau, Missouri, United States

MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri, United States

MU Health Care Goldschmidt Cancer Center, Jefferson City, Missouri, United States

Mercy Hospital Joplin, Joplin, Missouri, United States

Saint Luke's Hospital of Kansas City, Kansas City, Missouri, United States

Delbert Day Cancer Institute at PCRMC, Rolla, Missouri, United States

Mercy Clinic-Rolla-Cancer and Hematology, Rolla, Missouri, United States

Heartland Regional Medical Center, Saint Joseph, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Mercy Hospital South, Saint Louis, Missouri, United States

Missouri Baptist Medical Center, Saint Louis, Missouri, United States

Mercy Hospital Saint Louis, Saint Louis, Missouri, United States

Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri, United States

Mercy Hospital Springfield, Springfield, Missouri, United States

CoxHealth South Hospital, Springfield, Missouri, United States

Missouri Baptist Sullivan Hospital, Sullivan, Missouri, United States

BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri, United States

Billings Clinic Cancer Center, Billings, Montana, United States

Bozeman Health Deaconess Hospital, Bozeman, Montana, United States

Benefis Sletten Cancer Institute, Great Falls, Montana, United States

Great Falls Clinic, Great Falls, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

Community Medical Center, Missoula, Montana, United States

Nebraska Methodist Hospital, Omaha, Nebraska, United States

OptumCare Cancer Care at Charleston, Las Vegas, Nevada, United States

Renown Regional Medical Center, Reno, Nevada, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire, United States

Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey, United States

Cooper Hospital University Medical Center, Camden, New Jersey, United States

Englewood Hospital and Medical Center, Englewood, New Jersey, United States

Jersey City Medical Center, Jersey City, New Jersey, United States

Monmouth Medical Center Southern Campus, Lakewood, New Jersey, United States

Saint Barnabas Medical Center, Livingston, New Jersey, United States

Monmouth Medical Center, Long Branch, New Jersey, United States

Memorial Sloan Kettering Monmouth, Middletown, New Jersey, United States

Memorial Sloan Kettering Bergen, Montvale, New Jersey, United States

Jersey Shore Medical Center, Neptune, New Jersey, United States

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States

The Valley Hospital - Luckow Pavilion, Paramus, New Jersey, United States

Valley Health System Ridgewood Campus, Ridgewood, New Jersey, United States

Holy Name Hospital, Teaneck, New Jersey, United States

University of New Mexico Cancer Center, Albuquerque, New Mexico, United States

Northwell Health Imbert Cancer Center, Bay Shore, New York, United States

South Shore University Hospital, Bay Shore, New York, United States

Montefiore Medical Center-Einstein Campus, Bronx, New York, United States

Montefiore Medical Center-Weiler Hospital, Bronx, New York, United States

Montefiore Medical Center - Moses Campus, Bronx, New York, United States

Memorial Sloan Kettering Commack, Commack, New York, United States

Cancer Institute at Saint Francis Hospital, East Hills, New York, United States

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York, United States

Northwell Health Cancer Institute at Huntington, Greenlawn, New York, United States

Memorial Sloan Kettering Westchester, Harrison, New York, United States

Northwell Health/Center for Advanced Medicine, Lake Success, New York, United States

North Shore University Hospital, Manhasset, New York, United States

Long Island Jewish Medical Center, New Hyde Park, New York, United States

Mount Sinai West, New York, New York, United States

Lenox Hill Hospital, New York, New York, United States

Mount Sinai Hospital, New York, New York, United States

Manhattan Eye Ear and Throat Hospital, New York, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Upstate Cancer Center at Oswego, Oswego, New York, United States

Queens Cancer Center, Rego Park, New York, United States

University of Rochester, Rochester, New York, United States

Staten Island University Hospital, Staten Island, New York, United States

Stony Brook University Medical Center, Stony Brook, New York, United States

State University of New York Upstate Medical University, Syracuse, New York, United States

SUNY Upstate Medical Center-Community Campus, Syracuse, New York, United States

Memorial Sloan Kettering Nassau, Uniondale, New York, United States

Upstate Cancer Center at Verona, Verona, New York, United States

Wilmot Cancer Institute at Webster, Webster, New York, United States

Dickstein Cancer Treatment Center, White Plains, New York, United States

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina, United States

Duke University Medical Center, Durham, North Carolina, United States

East Carolina University, Greenville, North Carolina, United States

ECU Health Oncology Kinston, Kinston, North Carolina, United States

CarolinaEast Medical Center, New Bern, North Carolina, United States

Duke Women's Cancer Care Raleigh, Raleigh, North Carolina, United States

Duke Raleigh Hospital, Raleigh, North Carolina, United States

Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States

Sanford Broadway Medical Center, Fargo, North Dakota, United States

Sanford Roger Maris Cancer Center, Fargo, North Dakota, United States

Cleveland Clinic Akron General, Akron, Ohio, United States

Adena Regional Medical Center, Chillicothe, Ohio, United States

Case Western Reserve University, Cleveland, Ohio, United States

MetroHealth Medical Center, Cleveland, Ohio, United States

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio, United States

Cleveland Clinic Foundation, Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Mount Carmel East Hospital, Columbus, Ohio, United States

Riverside Methodist Hospital, Columbus, Ohio, United States

Grant Medical Center, Columbus, Ohio, United States

The Mark H Zangmeister Center, Columbus, Ohio, United States

Mount Carmel Health Center West, Columbus, Ohio, United States

Doctors Hospital, Columbus, Ohio, United States

Miami Valley Hospital, Dayton, Ohio, United States

Dublin Methodist Hospital, Dublin, Ohio, United States

Mount Carmel Grove City Hospital, Grove City, Ohio, United States

OhioHealth Mansfield Hospital, Mansfield, Ohio, United States

Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio, United States

Marietta Memorial Hospital, Marietta, Ohio, United States

Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio, United States

Licking Memorial Hospital, Newark, Ohio, United States

Newark Radiation Oncology, Newark, Ohio, United States

Southern Ohio Medical Center, Portsmouth, Ohio, United States

North Coast Cancer Care, Sandusky, Ohio, United States

University of Toledo, Toledo, Ohio, United States

Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio, United States

Saint Ann's Hospital, Westerville, Ohio, United States

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio, United States

Genesis Healthcare System Cancer Care Center, Zanesville, Ohio, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma, United States

Saint Charles Health System, Bend, Oregon, United States

Clackamas Radiation Oncology Center, Clackamas, Oregon, United States

Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon, United States

Bay Area Hospital, Coos Bay, Oregon, United States

Providence Newberg Medical Center, Newberg, Oregon, United States

Providence Willamette Falls Medical Center, Oregon City, Oregon, United States

Providence Portland Medical Center, Portland, Oregon, United States

Providence Saint Vincent Medical Center, Portland, Oregon, United States

Kaiser Permanente Northwest, Portland, Oregon, United States

Jefferson Abington Hospital, Abington, Pennsylvania, United States

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, United States

Ephrata Cancer Center, Ephrata, Pennsylvania, United States

Saint Vincent Hospital, Erie, Pennsylvania, United States

Adams Cancer Center, Gettysburg, Pennsylvania, United States

Jefferson Hospital, Jefferson Hills, Pennsylvania, United States

Sechler Family Cancer Center, Lebanon, Pennsylvania, United States

Forbes Hospital, Monroeville, Pennsylvania, United States

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Allegheny General Hospital, Pittsburgh, Pennsylvania, United States

West Penn Hospital, Pittsburgh, Pennsylvania, United States

Guthrie Medical Group PC-Robert Packer Hospital, Sayre, Pennsylvania, United States

Reading Hospital, West Reading, Pennsylvania, United States

Wexford Health and Wellness Pavilion, Wexford, Pennsylvania, United States

Asplundh Cancer Pavilion, Willow Grove, Pennsylvania, United States

WellSpan Health-York Cancer Center, York, Pennsylvania, United States

WellSpan Health-York Hospital, York, Pennsylvania, United States

Smilow Cancer Hospital Care Center - Westerly, Westerly, Rhode Island, United States

Ralph H Johnson VA Medical Center, Charleston, South Carolina, United States

Medical University of South Carolina, Charleston, South Carolina, United States

Prisma Health Cancer Institute - Faris, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Eastside, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Greer, Greer, South Carolina, United States

Prisma Health Cancer Institute - Seneca, Seneca, South Carolina, United States

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota, United States

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville, Tennessee, United States

University of Tennessee - Knoxville, Knoxville, Tennessee, United States

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis, Tennessee, United States

The Don and Sybil Harrington Cancer Center, Amarillo, Texas, United States

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, United States

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth, Texas, United States

UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas, United States

University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

University of Vermont Medical Center, Burlington, Vermont, United States

Inova Schar Cancer Institute, Fairfax, Virginia, United States

Inova Fair Oaks Hospital, Fairfax, Virginia, United States

Inova Fairfax Hospital, Falls Church, Virginia, United States

Inova Loudoun Hospital, Leesburg, Virginia, United States

Sentara Leigh Hospital, Norfolk, Virginia, United States

Sentara Norfolk General Hospital, Norfolk, Virginia, United States

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States

VCU Community Memorial Health Center, South Hill, Virginia, United States

Providence Regional Cancer System-Aberdeen, Aberdeen, Washington, United States

Overlake Medical Center, Bellevue, Washington, United States

PeaceHealth Saint Joseph Medical Center, Bellingham, Washington, United States

Providence Regional Cancer System-Centralia, Centralia, Washington, United States

Swedish Cancer Institute-Edmonds, Edmonds, Washington, United States

Providence Regional Cancer Partnership, Everett, Washington, United States

Swedish Cancer Institute-Issaquah, Issaquah, Washington, United States

Providence Regional Cancer System-Lacey, Lacey, Washington, United States

PeaceHealth Saint John Medical Center, Longview, Washington, United States

Swedish Medical Center-Ballard Campus, Seattle, Washington, United States

FHCC South Lake Union, Seattle, Washington, United States

Fred Hutchinson Cancer Center, Seattle, Washington, United States

Swedish Medical Center-First Hill, Seattle, Washington, United States

University of Washington Medical Center - Montlake, Seattle, Washington, United States

PeaceHealth United General Medical Center, Sedro-Woolley, Washington, United States

PeaceHealth Southwest Medical Center, Vancouver, Washington, United States

Providence Saint Mary Regional Cancer Center, Walla Walla, Washington, United States

West Virginia University Charleston Division, Charleston, West Virginia, United States

Langlade Hospital and Cancer Center, Antigo, Wisconsin, United States

Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin, United States

Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, United States

Aspirus Medford Hospital, Medford, Wisconsin, United States

Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon, Wisconsin, United States

Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee, Wisconsin, United States

Marshfield Clinic-Minocqua Center, Minocqua, Wisconsin, United States

Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin, United States

Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin, United States

Aspirus Regional Cancer Center, Wausau, Wisconsin, United States

Marshfield Medical Center - Weston, Weston, Wisconsin, United States

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin, United States

Welch Cancer Center, Sheridan, Wyoming, United States

Tom Baker Cancer Centre, Calgary, Alberta, Canada

BCCA-Vancouver Cancer Centre, Vancouver, British Columbia, Canada

BCCA-Vancouver Island Cancer Centre, Victoria, British Columbia, Canada

CancerCare Manitoba, Winnipeg, Manitoba, Canada

QEII Health Sciences Centre/Nova Scotia Health Authority, Halifax, Nova Scotia, Canada

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario, Canada

Ottawa Hospital and Cancer Center-General Campus, Ottawa, Ontario, Canada

Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City, Quebec, Canada

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec, Canada

Contact Details

Name: Cristina R. Ferrone, MD

Affiliation: Massachusetts General Hospital

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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