Spots Global Cancer Trial Database for Perifosine in Treating Patients With Locally Advanced, Unresectable, or Metastatic Pancreatic Cancer
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Trial Identification
Brief Title: Perifosine in Treating Patients With Locally Advanced, Unresectable, or Metastatic Pancreatic Cancer
Official Title: Phase II Trial Of Perifosine In Locally Advanced, Unresectable Or Metastatic Pancreatic Adenocarcinoma
Study ID: NCT00059982
Conditions
Interventions
Study Description
Brief Summary: RATIONALE: Perifosine may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth. PURPOSE: Phase II trial to study the effectiveness of perifosine in treating patients who have locally advanced, unresectable, or metastatic pancreatic cancer.
Detailed Description: OBJECTIVES: * Determine the activity of perifosine, in terms of objective response, in patients with locally advanced, unresectable, or metastatic pancreatic cancer. * Determine the response duration, progression-free survival, and overall survival of patients treated with this drug. * Determine the toxicity of this drug in these patients. OUTLINE: This is a multicenter study. Patients receive oral perifosine every 6 hours for a total of 6 doses and then once daily in the absence of disease progression or unacceptable toxicity. Patients are followed every 3 months for 3 years. PROJECTED ACCRUAL: A total of 35-84 patients will be accrued for this study within 21 months.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
CCOP - Carle Cancer Center, Urbana, Illinois, United States
CCOP - Northern Indiana CR Consortium, South Bend, Indiana, United States
CCOP - Iowa Oncology Research Association, Des Moines, Iowa, United States
Tufts - New England Medical Center, Boston, Massachusetts, United States
CCOP - Duluth, Duluth, Minnesota, United States
Mayo Clinic Cancer Center, Rochester, Minnesota, United States
CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States
MBCCOP-Our Lady of Mercy Cancer Center, Bronx, New York, United States
CCOP - Merit Care Hospital, Fargo, North Dakota, United States
CCOP - Scott and White Hospital, Temple, Texas, United States
Contact Details
Name: Robert de W. Marsh, MD
Affiliation: University of Florida
Role: STUDY_CHAIR
Name: Caio Max S. Rocha Lima, MD
Affiliation: H. Lee Moffitt Cancer Center and Research Institute
Role:
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