Spots Global Cancer Trial Database for Prophylactic Central Neck Dissection for Papillary Thyroid Cancer

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Trial Identification

Brief Title: Prophylactic Central Neck Dissection for Papillary Thyroid Cancer

Official Title: Prophylactic Central Neck Dissection for Papillary Thyroid Cancer

Study ID: NCT01510002

Conditions

Papillary Thyroid Cancer

Interventions

Total thyroidectomy

Total thyroidectomy + prophylactic central neck dissection

Study Description

Brief Summary: The purpose of this study is to determine whether prophylactic central neck dissection is beneficial for patients with papillary thyroid cancer staged preoperatively as node negative.

Detailed Description: Several respected organizations have recently recommended that total thyroidectomy plus prophylactic central neck dissection should be the standard operation for papillary thyroid cancer. However, it is still unclear if this approach has any benefit on survival or locoregional control of the disease. In addition, potential advantages of this more aggressive surgical approach should outweigh the risk of morbidity. The purpose of this retrospective cohort study is to determine whether prophylactic central neck dissection is beneficial for patients with papillary thyroid cancer staged preoperatively as node negative. In this study outcomes of total thyroidectomy versus this plus prophylactic central neck dissection for papillary thyroid cancer are compared in a 10-year follow-up. Patients operated between 1993 and 1997 (n=282) underwent total thyroidectomy alone, whereas patients operated between 1998 and 2002 (n=358) underwent total thyroidectomy plus prophylactic central neck dissection.