Spots Global Cancer Trial Database for Detection of BRAF Mutation on FNAB From Papillary Thyroid Carcinoma
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Trial Identification
Brief Title: Detection of BRAF Mutation on FNAB From Papillary Thyroid Carcinoma
Official Title: Immunohistochemical Detection of the BRAFV600E Mutation on Cytological Specimen in PTC
Study ID: NCT02561533
Conditions
Study Description
Brief Summary: Immunohistochemical detection of the BRAF-V600E mutation on pre-operative fine needle aspiration biopsy (FNAB) from patients suspected for papillary thyroid carcinoma, using the mutation specific antibody VE1.
Detailed Description: The BRAF mutation is reported to be present in approximately 50% of papillary thyroid carcinomas (PTC). The mutation has been associated with poor prognosis and more advanced disease stage. Therefore, pre-operative detection of the BRAF-V600E mutation may be of clinical interest in order to individualize treatment of patients with BRAF positive PTC. FNABs are performed immediately before the thyroid operation, and BRAF-V600E detection using VE1 is performed on clots. The VE1 stain is compared to the mutation status of the removed cancer or control tissue using the Cobas test.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Aarhus University Hospital, Aarhus C, , Denmark
Contact Details
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