Spots Global Cancer Trial Database for Diversity Analysis of Vaginal Microbiota on Women With High-risk Human Papillomavirus Infection
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Trial Identification
Brief Title: Diversity Analysis of Vaginal Microbiota on Women With High-risk Human Papillomavirus Infection
Official Title: Diversity Analysis of Vaginal Microbiota on Women With High-risk Human Papillomavirus Infection and Cervical Cytological Abnormalities.
Study ID: NCT03548740
Conditions
Interventions
Study Description
Brief Summary: Since other genital infections enhance HIV susceptibility by inducing inflammation, the investigators study the relationship between the vaginal microbiota composition and the risk of HPV infection, cervical cytological abnormalities.
Detailed Description: Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary but not sufficient for the development of cervical cancer. Additional factors correlated with HPV persistence include immunodeficiency caused by HIV, smoking, use of oral contraceptives and, more recently reported, vaginal dysbiosis. In a state of dysbiosis, there is a marked reduction of Lactobacillus and a high diversity of bacteria, with increased abundance of anaerobic bacterial species. Based on this, the investigators are going to analyze the changes of microbiota in women with high-risk HPV and the cervical lesions. And the investigators hope to figure out the difference and change in microbiota to realize the tanning of cervical lesions.
Keywords
Eligibility
Minimum Age: 25 Years
Eligible Ages: ADULT
Sex: FEMALE
Healthy Volunteers: Yes
Locations
Peking Union Medical College Hospital, Beijing, Beijing, China
Contact Details
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