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Spots Global Cancer Trial Database for Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome

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Trial Identification

Brief Title: Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome

Official Title: Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome

Study ID: NCT05819853

Study Description

Brief Summary: Girls and women 12-35 years old with obesity and polycystic ovarian syndrome who are on or off metformin, will receive a glucagon like peptide-1 receptor agonist intervention for 10 months to induce metabolic changes, weight loss and improve reproductive abnormalities.

Detailed Description: Polycystic ovary syndrome is one of the most common endocrinopathies in women, presents with anovulation in adolescence, and reproductive dysfunction is related to excess weight. After a 4-month observation period of either no medication or metformin treatment, females aged 12-35 years with obesity and polycystic ovary syndrome will receive 10 months of a glucagon-like peptide-1 receptor agonist to induce metabolic changes, weight loss and improve reproductive abnormalities. We will assess the relationship between weight loss and reproductive function, as well as identify if age, hormonal and metabolic measures and such insulin sensitivity and insulin secretion predict the response to glucagon-like peptide-1 receptor agonist therapy.

Eligibility

Minimum Age: 12 Years

Eligible Ages: CHILD, ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

University of Colorado Anschutz/Children's Hospital Colorado Aurora, Aurora, Colorado, United States

Contact Details

Name: Melanie Cree-Green, MD,PhD

Affiliation: University of Colorado Anschutz/Children's Hospital Colorado

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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