Spots Global Cancer Trial Database for Insulin and Polycystic Ovary Syndrome
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Trial Identification
Brief Title: Insulin and Polycystic Ovary Syndrome
Official Title: Determination if Direct Inhibition of Insulin Release With Diazoxide Decreases Renal Clearance of D-Chiroinositol (DCI) and Increases Circulating DCI in Obese Women With Polycystic Ovary Syndrome (PCOS)
Study ID: NCT00683774
Conditions
Interventions
Study Description
Brief Summary: Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women. This leads to a reduction in circulating DCI and insulin stimulated release of DCI-IPG.To determine if decreasing circulating insulin directly by inhibition of islet insulin release with diazoxide in obese women with PCOS 1)decreases the renal clearance of DCI and 2) increases the circulating concentration of DCI.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT
Sex: FEMALE
Healthy Volunteers: Yes
Locations
General Clinical Research Center, Richmond, Virginia, United States
Contact Details
Name: John E. Nestler, MD
Affiliation: Virginia Commonwealth University
Role: PRINCIPAL_INVESTIGATOR
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