Spots Global Cancer Trial Database for Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells

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Trial Identification

Brief Title: Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells

Official Title: Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells

Study ID: NCT05120518

Conditions

Pediatric Cancer

Interventions

Collection of post mortem tissue donation

Study Description

Brief Summary: The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG).

Detailed Description: The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG). This model system will then be subjected to 1) comprehensive histopathological and molecular characterizations during serial in vivo sub-transplantations; 2) cryopreserved for long term preservation of tumorigenicity; and 3) used for future biological studies and preclinical drug testing.