Spots Global Cancer Trial Database for Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities

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Trial Identification

Brief Title: Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities

Official Title: Prevention of Oxaliplatin-induced Peripheral Neuropathy - a Randomized Controlled Trial

Study ID: NCT05404230

Conditions

Peripheral Neuropathy

Colorectal Cancer

Interventions

Fish oil

Corn oil

Study Description

Brief Summary: The purpose of this study is to examine the effect of supplementary polyunsaturated fatty acids on nerve damage in the body's extremitites of patients treated with oxaliplatin containing chemotherapy after surgery for colorectal cancer.

Detailed Description: The primary objective of the present study is to examine if a high dosage of n-3 PUFA reduces the incidence and severity of chemotherapy-induced peripheral neuropathy (CIPN) 8 months after adjuvant oxaliplatin following surgery for high-risk colorectal cancer. An additional aim is to investigate whether n-3 PUFAs have an effect on nutritional status, cognition and mental status. Inflammatory mechanisms and biomarkers of CIPN in skin biopsies and in blood will be explored.